Patterns of Changing Risk Behavior in the CIDUS-3 Drug Users Intervention Trial

CIDUS-3 吸毒者干预试验中危险行为变化的模式

• 批准号: 8136838
• 负责人: MARY ELLEN MACKESY-AMITI
• 金额: $ 11.83万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136838
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Alcohol consumption; Attention; Attitude; Behavior; Behavior Therapy; Belief; Blood; Categories; Cities; Communicable Diseases; Control Groups; Counseling; Cross-Sectional Studies; Data; Data Analyses; Drug usage; Drug user; Educational Intervention; Effectiveness of Interventions; Emotional; Equipment; Growth; HIV; Hepatitis; Hepatitis B Virus; Hepatitis C; Hepatitis C virus; Heterogeneity; Individual; Infection; Injecting drug user; Injection of therapeutic agent; Intervention; Intervention Trial; Knowledge; Lead; Mediating; Methods; Modeling; Morbidity - disease rate; Outcome; Participant; Pattern; Persons; Population; Prevention; Prevention strategy; Preventive Intervention; Probability; Psychosocial Factor; Public Health; Randomized; Recommendation; Recruitment Activity; Research; Resources; Risk; Risk Behaviors; Screening procedure; Services; Sex Behavior; Sexual Partners; Sexual Transmission; Site; Subgroup; Testing; Time; Variant; arm; base; behavior change; cost; design; effective intervention; follow-up; improved; instrument; intervention effect; intervention program; mortality; novel; outreach; peer; person centered; programs; response; sex risk

DESCRIPTION (provided by applicant): Injection drug use is a serious public health problem, leading to blood-borne infections including HBC, HCV, and HIV. In spite of advances in the prevention of HIV/AIDS and hepatitis, injection drug use continues to contribute to new infections both directly through the sharing of injection equipment, and indirectly through sexual transmission from injection drug users (IDUs) to non-IDU sex partners. Behavioral interventions with IDUs are an important component of a comprehensive HIV prevention strategy. Enhanced interventions with IDUs have shown only modest effects over and above standard interventions. The key to improving interventions with IDUs may lie in understanding variations in responses to these interventions. Latent variable approaches (also known as mixture modeling) can be used to identify subgroups of individuals with similar response patterns. These approaches are often referred to as person-centered, in contrast to the traditional variable-centered approaches. To better understand how HIV prevention interventions influence injecting and sexual behavior of IDUs, we will conduct secondary analyses of data from the Third Collaborative Injection Drug Users Study / Drug Users Intervention Trial (CIDUS-3/DUIT). This study recruited young injection drug users in five U.S. cities to test a novel peer education intervention (PEI) against an attention control on changes in HIV/HCV risk behavior. We will use mixture modeling approaches, including latent class analysis, growth mixture modeling, and latent transition analysis, to analyze program outcomes. Our aim is to identify specific subgroups of IDUs for whom the intervention was most beneficial. Moreover, we seek to identify predictors of group membership which would enable us to assign individuals to the intervention that is most likely to have an impact. The proposed analyses will increase our understanding of the effects of the standard and enhanced interventions on injection and sexual risk behavior, and lead to recommendations for improving intervention efforts with injection drug users. The results may also have wider implications for strategizing prevention interventions with other populations. PUBLIC HEALTH RELEVANCE: Injection drug use facilitates blood-borne infectious diseases with significant morbidity and mortality, including HIV and hepatitis C. The CIDUS 3/DUIT Peer Education Intervention has the potential to significantly reduce injection-related risk behavior and sexual risk behavior among injection drug users. The proposed analyses will provide information to improve the implementation of this program and other HIV prevention interventions.

描述（由申请人提供）：注射吸毒是一个严重的公共卫生问题，导致血液传播感染，包括HBC，HCV和HIV。尽管在预防艾滋病毒/艾滋病和肝炎方面取得了进展，但注射吸毒继续助长新的感染，既有直接通过共用注射器具造成的，也有间接通过注射吸毒者向非注射吸毒者性伴侣的性传播造成的。对注射吸毒者的行为干预是艾滋病毒综合预防战略的一个重要组成部分。加强对注射吸毒者的干预，与标准干预相比，效果有限。改进对注射吸毒者的干预措施的关键可能在于了解对这些干预措施的反应的差异。潜变量方法（也称为混合模型）可用于识别具有相似反应模式的个体亚组。这些方法通常被称为以人为中心，与传统的以变量为中心的方法相反。 为了更好地了解艾滋病毒预防干预措施如何影响注射吸毒者的注射和性行为，我们将对第三次注射吸毒者合作研究/吸毒者干预试验（CIDUS-3/DUIT）的数据进行二次分析。这项研究招募了美国五个城市的年轻注射吸毒者，以测试一种新的同伴教育干预（PEI）对HIV/HCV风险行为变化的注意力控制。我们将使用混合建模方法，包括潜在类分析，增长混合建模和潜在转换分析，以分析程序的结果。我们的目的是确定特定的亚组注射吸毒者的干预是最有益的。此外，我们试图确定群体成员的预测因素，这将使我们能够将个人分配到最有可能产生影响的干预措施。拟议的分析将增加我们对标准和强化干预措施对注射和性风险行为的影响的理解，并为改善注射吸毒者的干预工作提出建议。研究结果还可能对制定其他人群的预防干预措施具有更广泛的影响。 公共卫生关系：注射吸毒助长了发病率和死亡率很高的血液传播传染病，包括艾滋病毒和丙型肝炎。CIDUS 3/DUIT同伴教育干预有可能显着减少注射吸毒者中与注射相关的风险行为和性风险行为。拟议的分析将提供信息，以改善该方案和其他艾滋病毒预防干预措施的实施。