REDUCTION OF NOCTURNAL HYPERTENSION IN PEDIATRIC RENAL TRANSPLANT RECIPIENTS
减少儿童肾移植受者的夜间高血压
基本信息
- 批准号:8167277
- 负责人:
- 金额:$ 0.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-04-01 至 2011-03-31
- 项目状态:已结题
- 来源:
- 关键词:Ambulatory Blood Pressure MonitoringArteriesBlood PressureCardiovascular systemCessation of lifeChildChildhoodClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseDataEventExcretory functionFoundationsFundingGrantHeartHourHypertensionInstitutionKidneyKidney TransplantationMeasuresOutcomePatternPharmaceutical PreparationsPopulationProteinsRenal functionResearchResearch PersonnelResourcesRunningSourceThickTimeTransplant RecipientsUnited States National Institutes of HealthUrinehigh riskimproved
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Elevated night-time blood pressure and an abnormal night-time decline in blood pressure (non-dipper pattern) have recently been recognized as important problems in children with renal transplants. These entities have been associated with kidney function decline, increased urine protein, cardiovascular events and death. The study objective is to investigate the effect of specific timing of blood pressure medication on night-time blood pressure in pediatric renal transplant recipients who are non-dippers. Two clinical trials, each with 14 treatment subjects and 14 controls, will run in parallel. One trial will examine the effect of shifting a single blood pressure medication from morning to evening hours. The other will examine the effect of adding a blood pressure medication in the evening. Blood pressure will be measured by 24 hour ambulatory blood pressure monitoring at baseline, 3 months and 6 months after the medication change. In addition, the effect of the medication change on heart wall thickness, artery stiffness, kidney function and urine protein excretion will be determined. These data will provide the foundation to improve cardiovascular and renal outcomes in this high risk population.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
夜间血压升高和夜间血压异常下降(非杓型)最近被认为是肾移植儿童的重要问题。这些实体与肾功能下降、尿蛋白增加、心血管事件和死亡相关。 本研究的目的是调查血压药物的具体时间对非杓型儿童肾移植受者夜间血压的影响。 两项临床试验将平行进行,每项试验有14名治疗受试者和14名对照受试者。一项试验将检查将单一血压药物从早上转移到晚上的效果。 另一个将检查晚上添加血压药物的效果。 将在基线、药物变更后3个月和6个月通过24小时动态血压监测测量血压。 此外,还将确定药物变化对心壁厚度、动脉僵硬度、肾功能和尿蛋白排泄的影响。 这些数据将为改善该高危人群的心血管和肾脏结局提供基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Christine B Sethna其他文献
Christine B Sethna的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Christine B Sethna', 18)}}的其他基金
Kids: Nocturnal Investigation into Glomerular Disease, Hypertension, and Transcriptomics (kNIGHT)
儿童:肾小球疾病、高血压和转录组学的夜间调查 (kNIGHT)
- 批准号:
10583680 - 财政年份:2023
- 资助金额:
$ 0.13万 - 项目类别:
A Pilot Study of Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Idiopathic Nephrotic Syndrome in Children
经皮耳迷走神经刺激治疗儿童特发性肾病综合征的初步研究
- 批准号:
10516390 - 财政年份:2022
- 资助金额:
$ 0.13万 - 项目类别:
A Pilot Study of Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Idiopathic Nephrotic Syndrome in Children
经皮耳迷走神经刺激治疗儿童特发性肾病综合征的初步研究
- 批准号:
10684191 - 财政年份:2022
- 资助金额:
$ 0.13万 - 项目类别:
相似海外基金
Analysis of spatiotemporal involvement of retinoic acid in pharyngeal arch arteries
视黄酸对咽弓动脉的时空影响分析
- 批准号:
22KJ2601 - 财政年份:2023
- 资助金额:
$ 0.13万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Molecular identification of the oxygen sensor(s) in the fetal ductus arteriosus and pulmonary artery: an integrated multiomic comparison of mitochondria in vital fetal arteries with opposing oxygen responses
胎儿动脉导管和肺动脉中氧传感器的分子识别:对胎儿重要动脉中具有相反氧反应的线粒体进行综合多组学比较
- 批准号:
462691 - 财政年份:2022
- 资助金额:
$ 0.13万 - 项目类别:
Operating Grants
Understanding the regulatory control of complex blood flow in conduit arteries and veins
了解导管动脉和静脉中复杂血流的调节控制
- 批准号:
RGPIN-2021-02563 - 财政年份:2022
- 资助金额:
$ 0.13万 - 项目类别:
Discovery Grants Program - Individual
Fetal cerebral arteries and prenatal alcohol exposure
胎儿脑动脉和产前酒精暴露
- 批准号:
10337722 - 财政年份:2022
- 资助金额:
$ 0.13万 - 项目类别:
Fetal cerebral arteries and prenatal alcohol exposure
胎儿脑动脉和产前酒精暴露
- 批准号:
10590708 - 财政年份:2022
- 资助金额:
$ 0.13万 - 项目类别:
Pregnenolone constricts cerebral vascular arteries through the direct modulation of BK ion channels
孕烯醇酮通过直接调节 BK 离子通道收缩脑血管动脉
- 批准号:
10441131 - 财政年份:2021
- 资助金额:
$ 0.13万 - 项目类别:
Understanding the regulatory control of complex blood flow in conduit arteries and veins
了解导管动脉和静脉中复杂血流的调节控制
- 批准号:
DGECR-2021-00028 - 财政年份:2021
- 资助金额:
$ 0.13万 - 项目类别:
Discovery Launch Supplement
Association of brain temperature increase and cerebrospinal fluid dynamics in chronic brain ischemia due to main trunk occlusion of cerebral arteries
脑动脉主干闭塞所致慢性脑缺血脑温度升高与脑脊液动力学的关系
- 批准号:
21K09108 - 财政年份:2021
- 资助金额:
$ 0.13万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Studying guinea pig development to discover how natural collateral arteries form
研究豚鼠的发育以发现自然侧支动脉是如何形成的
- 批准号:
10195510 - 财政年份:2021
- 资助金额:
$ 0.13万 - 项目类别:
Studying guinea pig development to discover how natural collateral arteries form
研究豚鼠的发育以发现自然侧支动脉是如何形成的
- 批准号:
10405492 - 财政年份:2021
- 资助金额:
$ 0.13万 - 项目类别: