REDUCTION OF NOCTURNAL HYPERTENSION IN PEDIATRIC RENAL TRANSPLANT RECIPIENTS

减少儿童肾移植受者的夜间高血压

• 批准号: 8167277
• 负责人: Christine B Sethna
• 金额: $ 0.13万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167277
• 关键词: Ambulatory Blood Pressure Monitoring; Arteries; Blood Pressure; Cardiovascular system; Cessation of life; Child; Childhood; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Data; Event; Excretory function; Foundations; Funding; Grant; Heart; Hour; Hypertension; Institution; Kidney; Kidney Transplantation; Measures; Outcome; Pattern; Pharmaceutical Preparations; Population; Proteins; Renal function; Research; Research Personnel; Resources; Running; Source; Thick; Time; Transplant Recipients; United States National Institutes of Health; Urine; high risk; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Elevated night-time blood pressure and an abnormal night-time decline in blood pressure (non-dipper pattern) have recently been recognized as important problems in children with renal transplants. These entities have been associated with kidney function decline, increased urine protein, cardiovascular events and death. The study objective is to investigate the effect of specific timing of blood pressure medication on night-time blood pressure in pediatric renal transplant recipients who are non-dippers. Two clinical trials, each with 14 treatment subjects and 14 controls, will run in parallel. One trial will examine the effect of shifting a single blood pressure medication from morning to evening hours. The other will examine the effect of adding a blood pressure medication in the evening. Blood pressure will be measured by 24 hour ambulatory blood pressure monitoring at baseline, 3 months and 6 months after the medication change. In addition, the effect of the medication change on heart wall thickness, artery stiffness, kidney function and urine protein excretion will be determined. These data will provide the foundation to improve cardiovascular and renal outcomes in this high risk population.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 夜间血压升高和夜间血压异常下降（非杓型）最近被认为是肾移植儿童的重要问题。这些实体与肾功能下降、尿蛋白增加、心血管事件和死亡相关。 本研究的目的是调查血压药物的具体时间对非杓型儿童肾移植受者夜间血压的影响。 两项临床试验将平行进行，每项试验有14名治疗受试者和14名对照受试者。一项试验将检查将单一血压药物从早上转移到晚上的效果。 另一个将检查晚上添加血压药物的效果。 将在基线、药物变更后3个月和6个月通过24小时动态血压监测测量血压。 此外，还将确定药物变化对心壁厚度、动脉僵硬度、肾功能和尿蛋白排泄的影响。 这些数据将为改善该高危人群的心血管和肾脏结局提供基础。