CLINICAL TRIAL: EFFECT OF GROWTH HORMONE TREATMENT ON RECOVERY FROM CUSHING'S DI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 库欣病是由脑下垂体良性肿瘤引起的皮质醇分泌过多，刺激肾上腺产生过多皮质醇，导致许多患者体重增加、糖尿病、高血压、骨质疏松症和抑郁症。在成功切除脑下垂体瘤后，库欣病的恢复通常会延长，通常至少一年。这项研究的目的是确定在成功的垂体手术后进行一年或两年的生长激素治疗是否加速了恢复的速度。这项研究涉及身体成分(脂肪质量、肌肉质量、骨密度)、运动强度、新陈代谢和生活质量衡量标准的研究。患者随机接受一年或两年的生长激素治疗，以比较第一年和第二年生长激素治疗的自然恢复率。三分之二的患者在第一年接受生长激素治疗，三分之一的患者接受安慰剂治疗；在第二年，所有患者都接受生长激素治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cushing's disease is excessive cortisol production caused by a benign tumor in the pituitary gland that stimulates the adrenal glands to produce too much cortisol causing weight gain, diabetes, high blood pressure, osteoporosis and depression in many patients. After successful removal of the pituitary tumor, recovery from Cushing's is often prolonged, usually at least one year. The purpose of this study is to determine if 1 or 2 years of growth hormone treatment after successful pituitary surgery accelerates the rate of recovery. The study involves the study of body composition (fat mass, muscle mass, bone density), exercise strength, metabolism and quality of life measures. Patients are randomized to receive either 1 or 2 years of growth hormone treatment to compare the rate of natural recovery with growth hormone treatment during the first year and the second year. Two thirds of patients receive growth hormone and one third of patients receive placebo during the first year; during the seond year, all patients receive growth hormone.