CLINICAL TRIAL: EFFECT OF GROWTH HORMONE TREATMENT ON RECOVERY FROM CUSHING'S DI

临床试验：生长激素治疗对库欣病康复的影响

• 批准号: 8167151
• 负责人: MARY L VANCE
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167151
• 关键词: Adrenal Glands; Aftercare; Benign; Body Composition; Bone Density; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Excision; Exercise; Fatty acid glycerol esters; Funding; Grant; Hydrocortisone; Hypertension; Institution; Measures; Mental Depression; Metabolism; Operative Surgical Procedures; Osteoporosis; Patients; Pituitary Gland; Pituitary Neoplasms; Pituitary-dependent Cushing' s disease; Placebos; Production; Quality of life; Randomized; Recovery; Research; Research Personnel; Resources; Somatotropin; Source; United States National Institutes of Health; Weight Gain; muscle form; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cushing's disease is excessive cortisol production caused by a benign tumor in the pituitary gland that stimulates the adrenal glands to produce too much cortisol causing weight gain, diabetes, high blood pressure, osteoporosis and depression in many patients. After successful removal of the pituitary tumor, recovery from Cushing's is often prolonged, usually at least one year. The purpose of this study is to determine if 1 or 2 years of growth hormone treatment after successful pituitary surgery accelerates the rate of recovery. The study involves the study of body composition (fat mass, muscle mass, bone density), exercise strength, metabolism and quality of life measures. Patients are randomized to receive either 1 or 2 years of growth hormone treatment to compare the rate of natural recovery with growth hormone treatment during the first year and the second year. Two thirds of patients receive growth hormone and one third of patients receive placebo during the first year; during the seond year, all patients receive growth hormone.

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