CLINICAL TRIAL: PHASE II STUDY OF UNADJUVANTED NOVARTIS H1N1 INFLUENZA VACCINE I

临床试验:未佐剂诺华 H1N1 流感疫苗 I 的 II 期研究

基本信息

  • 批准号:
    8167206
  • 负责人:
  • 金额:
    $ 18.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-03-01 至 2013-02-28
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is a need for early information on the safety and immunogenicity of H1N1 influenza vaccination on patients with asthma, especially those on high doses of inhaled glucocorticosteroids and oral glucocorticosteroids, Based on clinical data from other novel influenza A viruses, a higher dose, or multiple doses of an unadjuvanted, inactivated influenza H1N1 vaccine may be necessary to confer protection to a maximal number of vaccine recipients. The capacity of a novel unadjuvanted, inactivated influenza H1N1 vaccine to elicit an optimal response in patients with mild/moderate, or severe asthma is not known. This protocol will explore the antibody response following vaccination at two different dose levels (15 mcg and 30 mcg). Each dose level of inactivated influenza H1N1 vaccine will require two administrations that will be given 21 days apart. This study will also assess the immune response following a single dose of vaccine, to test whether individuals have any pre-existing prime immunity, such that the initial H1N1 vaccination serves as a boost, thus conferring a more rapid time to protection with the need for fewer doses. Antibody responses will be assessed at 8 days after each vaccine administration to evaluate the development of an anamnestic response. In addition, antibody responses will be assessed at 21 days after each dose. This study will utilize the H1N1 unadjuvanted inactivated Influenza A (H1N1) 2009 vaccine from Novartis.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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WILLIAM GERALD TEAGUE其他文献

WILLIAM GERALD TEAGUE的其他文献

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{{ truncateString('WILLIAM GERALD TEAGUE', 18)}}的其他基金

Study of Acid Reflux Therapy for Children with Asthma
儿童哮喘胃酸反流治疗研究
  • 批准号:
    6908647
  • 财政年份:
    2006
  • 资助金额:
    $ 18.58万
  • 项目类别:
Study of Acid Reflux Therapy for Children with Asthma
儿童哮喘胃酸反流治疗研究
  • 批准号:
    7644919
  • 财政年份:
    2006
  • 资助金额:
    $ 18.58万
  • 项目类别:
Study of Acid Reflux Therapy for Children with Asthma
儿童哮喘胃酸反流治疗研究
  • 批准号:
    7474764
  • 财政年份:
    2006
  • 资助金额:
    $ 18.58万
  • 项目类别:
Study of Acid Reflux Therapy for Children with Asthma
儿童哮喘胃酸反流治疗研究
  • 批准号:
    7878802
  • 财政年份:
    2006
  • 资助金额:
    $ 18.58万
  • 项目类别:
Study of Acid Reflux Therapy for Children with Asthma
儿童哮喘胃酸反流治疗研究
  • 批准号:
    7288750
  • 财政年份:
    2006
  • 资助金额:
    $ 18.58万
  • 项目类别:

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  • 批准号:
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  • 批准号:
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  • 财政年份:
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  • 财政年份:
    2014
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加州呼吸哮喘计划
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成人哮喘、慢性阻塞性肺病和睡眠呼吸障碍多种表型的终生临床预测因素和危险因素是什么?
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    nhmrc : 1021275
  • 财政年份:
    2012
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    $ 18.58万
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CALIFORNIA BREATHING ASTHMA PROGRAM/CALIFORNIA DEPT OF PUBLIC HEALTH
加州呼吸哮喘计划/加州公共卫生部
  • 批准号:
    8328114
  • 财政年份:
    2009
  • 资助金额:
    $ 18.58万
  • 项目类别:
CALIFORNIA BREATHING ASTHMA PROGRAM/CALIFORNIA DEPT OF PUBLIC HEALTH
加州呼吸哮喘计划/加州公共卫生部
  • 批准号:
    8135198
  • 财政年份:
    2009
  • 资助金额:
    $ 18.58万
  • 项目类别:
CALIFORNIA BREATHING ASTHMA PROGRAM/CALIFORNIA DEPT OF PUBLIC HEALTH
加州呼吸哮喘计划/加州公共卫生部
  • 批准号:
    7842022
  • 财政年份:
    2009
  • 资助金额:
    $ 18.58万
  • 项目类别:
CALIFORNIA BREATHING ASTHMA PROGRAM/CALIFORNIA DEPT OF PUBLIC HEALTH
加州呼吸哮喘计划/加州公共卫生部
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    7924810
  • 财政年份:
    2009
  • 资助金额:
    $ 18.58万
  • 项目类别:
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