Sleep Disordered Breathing and Asthma Morbidity in Inner City School Children

内城学童的睡眠呼吸障碍和哮喘发病率

• 批准号: 8784367
• 负责人: Lakiea S Wright
• 金额: $ 7.49万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-17 至 2015-07-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8784367
• 关键词: Accounting; Adult; Affect; Air Pollution; Allergens; Asthma; Boston; Canis familiaris; Carbon Dioxide; Caregivers; Child; Childhood; Childhood Asthma; Chronic Disease; Cities; Commit; Communities; Complex; Data; Dictyoptera; Disadvantaged; Endotoxins; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Epidemiology; Exposure to; Felis catus; Fostering; Frequencies; Funding; Future; Habits; Health; Health Policy; Home environment; Intervention; Intervention Trial; Lead; Longitudinal Studies; Master of Public Health; Measures; Medicine; Mentorship; Molds; Morbidity - disease rate; Mus; National Institute of Allergy and Infectious Disease; Neighborhoods; Nitrogen Dioxide; Outcome; Play; Population; Postdoctoral Individual National Research Service Award; Prevalence; Public Health; Public Policy; Pulse Oximetry; Questionnaires; Recruitment Activity; Relative (related person); Reporting; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Risk Factors; Role; School-Age Population; Schools; Shapes; Sleep; Sleep Apnea Syndromes; Sleep disturbances; Snoring; Statistical Models; Students; Symptoms; Testing; Time; Training; Training Programs; Vulnerable Populations; Work; Wrist; actigraphy; airborne allergen; base; career; career development; cohort; design; environmental intervention; health disparity; improved; inner city; mortality; parent grant; public health relevance; pyroglyphid; research clinical testing; skills

DESCRIPTION (provided by applicant): Asthma disproportionately affects inner-city children. Asthma morbidity in the inner-city is likely multifactorial with environmental exposures playing a critical role. Inner city populations are vulnerable to sleep disturbances; however, the relationship between sleep disordered breathing (SDB) and asthma morbidity has not been thoroughly investigated in inner city asthmatics. The primary objective of this study is to investigate the effect of SDB on asthma morbidity. We hypothesize that SDB will be independently related to increased asthma morbidity. The secondary objective of this study is to determine the differential effect of home and school environmental exposures (including common aeroallergens [dust mite, cat, dog, mouse, cockroach, and mold], endotoxin, and air pollution [black carbon and nitrogen dioxide]) on SDB and asthma morbidity. There is a paucity of studies that have examined the role of environmental exposures on the complex associations of SDB and asthma morbidity. We hypothesize that school based exposures will independently contribute to SDB and asthma morbidity. This study is unique because we will be among the first to examine the effect of school/classroom specific environmental exposures on SDB and asthma morbidity. To test these hypotheses, we will evaluate the children enrolled in an established cohort, the Allergens in Inner-City Schools and Childhood Asthma (Dr. Wanda Phipatanakul, PI, NIAID R-01-AI-073964), for SDB (using wrist actigraphy and pulse oximetry). This proposal details a one year project to provide Dr. Wright with training and expertise in the assessment of environmental exposures and its effects on SDB and asthma morbidity with a specific focus on the school environment of inner city asthmatics. Dr. Wright will work under the mentorship of Dr. Phipatanakul, an expert in asthma and environmental epidemiology, in addition to an extraordinary team of researchers, including Drs. Joshua Boyce (with expertise in asthma), Susan Redline (with expertise in sleep medicine), and Brent Coull (with expertise in environmental statistical modeling), who have committed their time and resources to facilitate Dr. Wright's career development and the successful completion of the proposed project. As part of the research training program, Dr. Wright will complete a Master of Public Health with a concentration in environmental health in order to acquire the necessary epidemiologic and bio-statistical skills to become a successful independent junior investigator.

描述（由申请人提供）：哮喘不成比例地影响内城儿童。城市内城市中的哮喘发病率可能是多因素的，环境暴露起着至关重要的作用。城市内部人口容易受到睡眠障碍。然而，在内城哮喘患者中，尚未对睡眠失调（SDB）和哮喘发病率之间的关系进行彻底研究。这项研究的主要目的是研究SDB对哮喘发病率的影响。我们假设SDB将与哮喘发病率增加有关。这项研究的次要目的是确定家庭和学校环境暴露的差异效应（包括常见的气溶胶[尘螨，猫，狗，小鼠，蟑螂和霉菌]，内毒素和空气污染[黑色碳和氮二氧化氮]对SDB和SDB的差异。很少研究研究了环境暴露在SDB和哮喘发病率的复杂关联上的作用。我们假设基于学校的暴露将独立促进SDB和哮喘发病率。这项研究是独一无二的，因为我们将成为第一个研究学校/教室特定环境暴露对SDB和哮喘发病率的影响的人之一。为了检验这些假设，我们将评估既定队列的儿童，城市学校和童年哮喘的过敏原（Wanda Phipatanakul博士，PI，NIAID R-01-AI-073964），用于SDB（使用手腕动力学和脉搏OXimetry）。该提案详细介绍了一年的项目，旨在为赖特博士提供培训和专业知识，以评估环境暴露及其对SDB和哮喘发病率的影响，并特别关注内城哮喘患者的学校环境。赖特博士将在哮喘和环境流行病学专家Phipatanakul博士的指导下工作，除了包括Drs在内的非凡研究人员团队。约书亚·博伊斯（Joshua Boyce）（在哮喘方面具有专业知识），苏珊·雷德林（Susan Redline）（具有睡眠医学专业知识）和布伦特·库尔（Brent Coull）（在环境统计建模方面具有专业知识），他们花了时间和资源来促进赖特博士的职业发展，并成功完成了该项目的项目。作为研究培训计划的一部分，Wright博士将完成一位专注于环境健康的公共卫生硕士，以便获得必要的流行病学和生物统计技能，以成为成功的独立初级研究员。