CLINICAL TRIAL: A COMPARISON OF HYDROCHLOROTHIAZIDE AND METOLAZONE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要目的是确定哪种药物组合在消除充血性心力衰竭患者体内多余液体方面最有效。 其他目标： 目的：测定速尿[拉西汀]单独以及与氢氯噻嗪[HCTZ]或美托拉酮[扎罗昔林]合用的作用时间。 为了确定联合治疗对某些荷尔蒙的激活的影响，这些荷尔蒙是导致体内液体过多的原因。 目的：探讨美托拉宗和氢氯噻嗪对预测异常心率的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this study is to determine which combination of medications is the most effective in eliminating excess fluids from the body in congestive heart failure patients. Other aims: To determine the duration of action of furosemide [Lasix] by itself and in combination with either hydrochlorothiazide [HCTZ] or metolazone [Zaroxolyn]. To determine the effect of combination therapy on activation of certain hormones responsible for excess fluids in the body. To determine the influence that metolazone and hydrochlorothiazide have on predicting abnormal heart beats.