THE IMPORTANCE OF INSULIN TIMING IN TYPE 1 DIABETES

胰岛素注射时机对于 1 型糖尿病的重要性

• 批准号: 8166628
• 负责人: David S Schade
• 金额: $ 3.29万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166628
• 关键词: Address; Blood; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Diabetes Mellitus; Funding; Glucose; Grant; Hypoglycemia; Incidence; Institution; Insulin; Insulin-Dependent Diabetes Mellitus; Quality of life; Questionnaires; Regimen; Research; Research Personnel; Resources; Source; Therapeutic; Time; United States National Institutes of Health; cohort; diabetic patient; glucose monitor; type I diabetic; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims: 1) To determine the change in A1C in a cohort of type 1 diabetic patients utilizing Timing of the premeal insulin administration compared to an equivalent control group in which Timing is not utilized. 2) To determine the change in postprandial glucose excursion (using Continuous Glucose Monitoring (CGM) in a cohort of type 1 diabetic patients on IIT when Timing is introduced into their therapeutic regimen compared to an equivalent control group in which Timing is not utilized. 3) To determine the change in blood 1,5-anhydroglucitol (1,5-AG) (using GlycoMark) over a 6-month period in a cohort of type 1 diabetic patients on IIT when Timing is introduced into their regimen compared to equivalent control group in which Timing is not utilized. 4) To determine change in incidence of hypoglycemia (using CGM) when Timing of the premeal insulin administration is introduced into an IIT regimen. 5) To assess improvement in QOL (using the Diabetes Quality of Life in Clinical Trials Questionnaire Revised (DQLCTQ-R) in volunteers utilizing Timing in their IIT regimen. Study will address the importance and benefits of Timing when incorporated into an IIT regimen, and the mechanism of this benefit.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 1)确定使用餐前胰岛素给药时机的1型糖尿病患者队列中A1C的变化，并与不利用时机的同等对照组进行比较。 2)确定在IIT治疗方案中引入计时的1型糖尿病患者与没有计时的同等对照组相比，餐后血糖漂移的变化(使用连续血糖监测(CGM)在接受IIT的一组患者中)。 3)在一组接受IIT治疗的1型糖尿病患者中，将计时引入他们的治疗方案，并与没有计时的同等对照组进行比较，以确定1，5-脱水葡萄糖醇(1，5-AG)(使用GlycoMark)在6个月期间的血液变化。 4)在IIT方案中引入餐前胰岛素给药时机，以确定低血糖发生率的变化(使用CGM)。 5)评估志愿者的生活质量改善(使用修订的临床试验中的糖尿病生活质量问卷(DQLCTQ-R))，利用他们的IIT方案的时机。 研究将探讨计时纳入IIT方案的重要性和益处，以及这种益处的机制。