POSTPRANDIAL HYPERGLYCEMIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究正在研究高血糖[葡萄糖]对“氧化应激”(对血管内皮细胞的损害)的影响。许多糖尿病患者都有健康问题[如血液循环不良、心脏病发作和中风]，这些问题与一种名为动脉粥样硬化(由于血管壁上沉积的斑块导致血管狭窄)有关。此前的研究表明，餐后高血糖浓度与动脉粥样硬化的风险之间存在联系。本研究旨在探讨这一现象背后的机制。这项研究将比较三种不同的血糖范围以及这些范围对氧化应激的影响。这项研究将包括一次门诊筛查访问和三次住院研究访问，如下所述。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is studying the effects of high blood sugar [glucose] on "oxidative stress" [damage done to the cells lining blood vessels]. Many patients with diabetes have health problems [such as poor circulation, heart attacks, and strokes] that are related to a condition called atherosclerosis [narrowing of the blood vessels due to the deposits of plaque on the blood vessel walls]. Previous studies have shown that there is a link between high glucose concentrations following meals and the risk of atherosclerosis. This study aims to investigate the mechanism behind this. The study will compare 3 different blood sugar ranges and the effects these ranges have on oxidative stress. The study will involve one outpatient screening visit and three inpatient study visits, as outlined below.