High-throughput desk-top FT-ICR instrument; Phase II SBIR application for the 1R4

高通量台式FT-ICR仪器；

• 批准号: 8136465
• 负责人: ALEXANDER MISHARIN
• 金额: $ 37.5万
• 依托单位: MASSTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136465
• 关键词: Appearance; Biological Sciences; Cells; Characteristics; Charge; Chromatography; Complex Mixtures; Cyclotrons; Data; Detection; Devices; Dissociation; Electrodes; Electrons; Electrospray Ionization; Engineering; Evaluation; Fourier Transform; Frequencies; Future; Goals; Government; Grant; Hand; Height; High Pressure Liquid Chromatography; Hybrids; Information Sciences; Ions; Left; Legal; Libraries; Manufacturer Name; Marketing; Mass Spectrum Analysis; Measurement; Methods; Motion; Peptides; Performance; Persons; Phase; Post Translational Modification Analysis; Price; Progress Reports; Proteins; Proteomics; Research; Resolution; SHFM1 gene; Scanning; Scheme; Screening procedure; Services; Small Business Innovation Research Grant; Speed; System; Techniques; Technology; Time; Work; base; clinical application; combinatorial; drug discovery; high throughput technology; improved; instrument; instrumentation; mass spectrometer; novel; operation; protein aminoacid sequence; public health relevance; research study; small molecule; tandem mass spectrometry; time use; ultra high resolution

DESCRIPTION (provided by applicant): We propose to develop a novel desk-top FT-ICR mass spectrometer with O-trap FT-ICR cell technology for high throughput, ultra-high performance MS and multy-type (CID, ECD, HECD, and EDD) MS/MS analysis (4 - 10 spectra per second with R = 100,000 - 25,000 at m/z 400) for proteomics research and small molecule applications. PUBLIC HEALTH RELEVANCE: We propose a novel high-throughput 5T desk-top FT-ICR instrument.

描述（由申请人提供）：我们建议开发一种新型台式FT-ICR质谱仪，采用O-trap FT-ICR池技术，用于蛋白质组学研究和小分子应用的高通量、超高性能MS和多种类型（CID、ECD、HECD和EDD）MS/MS分析（每秒4 - 10个光谱，R = 100，000 - 25，000，m/z 400）。 公共卫生相关性：我们提出了一种新型的高通量5 T台式FT-ICR仪器。