The Ninth Annual Pharmacogenetics in Psychiatry Meeting

描述(申请人提供)：一年一度的精神病学药物遗传学(PIP)会议为介绍和讨论过去八年来精神病学药物遗传学领域的新发展提供了一个独特的论坛。以前的会议着重讨论了以下主题：抗精神病药物和抗抑郁药物的临床反应的预测；与不良副作用的发展相关的基因；新的统计方法；以及最近的全基因组关联(GWAS)方法对药物遗传学的影响。此外，会议汇集了从事不同研究领域的研究人员，从分子遗传学家到临床试验调查人员，来自学术界和工业界，以产生真正的跨学科方法来解决精神药物临床反应差异的问题。参加会议的人数不断增加，与会者的评价很好，参加会议的合作努力也越来越多，这些都证明了会议非常成功。 之前的PIP会议都是在纽约市举行的，得到了各种来源的共同支持：扎克·希尔赛德医院、行业支持的无限制教育补助金和注册费。因为我们认为这个项目应该在持续的基础上得到稳定、独立的财务支持，所以在本申请中，我们请求NIMH提供支持，使我们能够在其他资源的财务支持不断减少的情况下继续这次会议。此外，我们希望为有兴趣在这个快速发展的领域发展研究事业的新研究人员提供旅行大奖。因此，在这份申请中，我们寻求为年度PIP会议提供额外的五年资金支持，下一次会议定于2010年4月23日和24日在纽约市举行。 公共卫生相关性：精神病学药物遗传学是一个快速发展的研究领域，旨在确定调节精神药物反应变化的遗传因素。将药物遗传学引入临床实践将对精神病患者的护理产生重大影响，PIP会议为介绍和讨论这一领域的最新数据提供了一个专门的论坛。

DESCRIPTION (provided by applicant): The annual Pharmacogenetics in Psychiatry (PIP) meeting has provided a unique forum for the presentation and discussion of new developments in the field of psychiatry pharmacogenetics for the past eight years. Previous meetings have been highlighted by discussion of topics including: prediction of clinical response to antipsychotic and antidepressant drugs; genes associated with the development of adverse side effects; novel statistical approaches; and most recently, the implication of genome-wide association (GWAS) approaches for pharmacogenetics. Moreover, the meeting has brought together investigators working in diverse areas of research, from molecular geneticists to clinical trial investigators, from academia and industry in order to engender true interdisciplinary approaches to the problem of variation in clinical response to psychotropic drugs. The meetings have been highly successful as evidenced by continued growth in participation, excellent evaluations from meeting attendees, and the number of collaborative efforts that have grown out of meeting participation. The prior PIP meetings have taken place in New York City with pooled support from a variety of sources: The Zucker Hillside Hospital, industry supported unrestricted educational grants, and registration fees. Because we believe that this program should have stable, independent financial support on an ongoing basis, in this application, we request support from the NIMH to enable us to continue this meeting in the face of declining financial support from other resources. Moreover, we hope to provide Travel Awards to deserving new investigators interested in developing research careers in this rapidly developing field. Therefore, in this application, we seek support for additional five years of funding for the annual PIP meeting, with the next meeting scheduled in New York City, April 23 & 24, 2010. PUBLIC HEALTH RELEVANCE: Psychiatric pharmacogenetics is a rapidly evolving field of research that aims to identify genetic factors mediating the variation in psychotropic drug response. The introduction of pharmacogenetics into clinical practice would have significant impact on the care of mentally ill patients and the PIP meeting serves to provide a dedicated forum for the presentation and discussion of the latest data in this area of "personalized medicine".