Bone Marrow Stromal Cells as Mitigators of Radiation Injury
Bone Marrow Stromal Cells as Mitigators of Radiation Injury
批准号:
8938111
负责人:
Deborah Citrin
金额:
$45.42万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AcuteAllogenicAnimalsBone MarrowCellsChronicCutaneousDataDerivation procedureDermatitisEventFibrosisGoalsInflammationInflammatoryInfusion proceduresInjuryLate Radiation InjuryLiteratureLungMarrowModelingMusOutcomeRadiationRadiation InjuriesRadiation ToxicitySiteStromal CellsSystemTissuesWorkclinical applicationcytokineimprovedin vivolung injurymanresponse to injury
中文摘要
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英文摘要
Thus far, our studies have documented that bone marrow stromal cells are an effective mitigator of radiation injury. We have found that delivery of bone marrow stromal cells can reduce pulmonary and cutaneous fibrosis after radiation exposure. In these models our delivery system has shown an extension in survival in exposed mice with lung injury and reduction in cutaneous fibrosis. We continue to evaluate if bone marrow stromal cells can mitigate radiation dermatitis and lethal total body exposures.
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会议论文
Evaluation of Novel Radiation Modifiers
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批准号:8552862
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项目类别:
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资助金额:$40.66万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Bone Marrow Stromal Cells as Mitigators of Radiation Injury
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批准号:8763514
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项目类别:
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资助金额:$73.19万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Targeting mechanisms of radiation resistance
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批准号:8938188
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项目类别:
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资助金额:$45.42万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:9153696
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项目类别:
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资助金额:$86.67万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Screening to identify protectors and mitigators of Radiation GI Syndrome
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批准号:9556728
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项目类别:
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资助金额:$65.62万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity From Irradiation
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批准号:10926083
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项目类别:
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资助金额:$182.99万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Targeting mechanisms of radiation resistance
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批准号:10014725
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项目类别:
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资助金额:$72.42万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity From Irradiation
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批准号:10262171
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项目类别:
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资助金额:$147.42万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Screening to identify protectors and mitigators of Radiation GI Syndrome
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批准号:10486958
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项目类别:
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资助金额:$77.43万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Targeting mechanisms of radiation resistance
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批准号:9153977
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项目类别:
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资助金额:$43.33万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Evaluation of Novel Radiation Modifiers
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批准号:7965759
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项目类别:
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资助金额:$74.23万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8763251
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项目类别:
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资助金额:$73.19万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8349205
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项目类别:
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资助金额:$53.72万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:7592997
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项目类别:
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资助金额:$57.76万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity From Irradiation
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批准号:10014468
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项目类别:
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资助金额:$144.83万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8937873
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项目类别:
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资助金额:$90.84万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8552863
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项目类别:
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资助金额:$40.66万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity From Irradiation
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批准号:10702425
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项目类别:
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资助金额:$184.66万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Screening to identify protectors and mitigators of Radiation GI Syndrome
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批准号:10262442
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项目类别:
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资助金额:$73.71万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
Mechanisms of Normal Tissue Toxicity
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批准号:8157503
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项目类别:
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资助金额:$20.41万
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财政年份:--
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负责人:Deborah Citrin
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依托单位:
海外基金