Modulation of Radiation Response

辐射响应的调节

• 批准号: 8938201
• 负责人: Aparna Kesarwala
• 金额: $ 69.26万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8938201
• 关键词: Animal Model; Biological Assay; Dependency; Dose; Goals; Human; In Vitro; Ionizing radiation; Pathway interactions; Radiation; Testing; Xenograft Model; in vivo; interest; neoplastic cell; novel; response; tumor

We have tested several novel modulators that target the pathways relevant to ionizing radiation. We have used clonogenic survival assays of human tumor cells in vitro to characterize the temporal components and dose-dependency of the response to ionizing radiation. We have also begun testing these modulators in in vivo xenograft models to determine the correlation with our in vitro results. We have also begun investigating potential mechanisms and related pathways in order to better understand our results.

我们已经测试了几种新的调节剂，靶向电离辐射相关的途径。我们已经在体外使用了人类肿瘤细胞的克隆存活测定来表征对电离辐射的响应的时间成分和剂量依赖性。我们还开始在体内异种移植模型中测试这些调节剂，以确定与我们的体外结果的相关性。我们还开始研究潜在的机制和相关途径，以便更好地理解我们的结果。