Library Synthesis Core

Q.1库合成核心。 Q.I7人员：图书馆综合核心(LSC)的持续目标将是开发和传播 化学方法学和合成化学库，如项目说明(P节)所述。 LSC被细分为本提案中描述的三个项目，尽管 项目团队成员和方法的重叠将相当广泛。 LSC内的每个项目小组将由一名博士后研究员和两名研究生组成。 在库合成过程中，项目小组将负责方法开发， 文库合成和纯度评估。在文库合成和纯度评估完成后， 图书馆将交付给行政和复合库存核心(ACIC)，以便输入数据库和 储存，并最终运往化学图书馆联盟(CLC)的成员。在LSC内部， 助理总监(Aaron Beeler)监督所有三个项目的日常管理，与 博士后、研究生、技术人员。他还负责确保 综合核心实现了其规定的目标，其中包括：(1)为每个项目设计库；(2) 开发和验证用于产生和提纯化学品的方法和反应规程 图书馆；(3)在评估纯度方面与图书馆分析服务小组互动；(4) 将图书馆移交给ACIC进行存储和维护；以及(5)与ACIC人员互动，以 实施生物和社区外展计划。有机合成专家(OSS)将 主要实施基于LSC开发的方法的库合成。 图书馆综合核心内的信息技术系统支助将由阿鲁纳提供 杰恩。这将主要包括监督LSC使用的计算机和数据库。戴尔·阿奎拉诺 复合馆长将继续协助将复合藏品从LSC转移到ACIC。 订单和其他行政职责将由保罗·法拉利和莎拉·科宁提供。

Q.1 Library Synthesis Core. Q.I7 Personnel: The continuing goal of the Library Synthesis Core (LSC) will be to develop and disseminate chemical methodology and synthesize chemical libraries as described in the project descriptions (section P). The LSC is subdivided between the three projects described in this proposal, though the interactions between project team members and methodology overlap will be quite extensive. Each project subgroup within the LSC will consist of one postdoctoral fellow and two graduate students. In the course of the library synthesis, the project subgroups will be responsible for methods development, library synthesis, and purity assessment. After library synthesis and purity assessment are completed, the libraries will be delivered to the Administrative and Compound Inventory Core (ACIC) for database entry and storage, and ultimately shipped to members of the Chemical Library Consortium (CLC). Within the LSC, the Assistant Director (Aaron Beeler) oversees the day-to-day management of all three projects, interacting with the postdoctoral students, graduate students, and technicians. He is also responsible for ensuring that the synthesis core accomplishes its stated goals, which include: (1) design of libraries for each project; (2) development and validation of methodologies and reaction protocols for generation and purification of chemical libraries; (3) interacting with the analytical services group for library analysis in the assessment of purity; (4) transferring the libraries to the ACIC for storage and maintenance; and (5) interacting with ACIC personnel to implement the biological and community outreach programs. The Organic Synthesis Specialists (OSS) will primarily implement library synthesis based on methodologies developed in the LSC. Information technology systems support within the Library Synthesis Core will be provided by Aruna Jain. This will mainly consist of oversight of the computers and databases used by the LSC. Dayle Acquilano, the Compound Curator, will continue to facilitate transfer of compound collections from the LSC to the ACIC. Placement of orders and other administrative duties will be provided by Paul Ferrari and Sarah Coenen.