Investigating Molecular-Genetic Correlates of Fatigue

四项研究正在积极招募人员，以解决疲劳计划的目标。一项题为《接受局部外照射治疗的癌症患者疲劳的分子遗传学相关性》的研究09-NR-0088跟踪了接受局部放射治疗的前列腺癌患者的疲劳症状。另一项研究09-NR-0131，“健康个体的疲劳”探索了健康志愿者的疲劳。研究报告10-NR-0128“外照射治疗后癌症患者线粒体功能障碍与疲劳之间的关系”专门探讨了线粒体基因表达的变化，这些基因与接受局部放射治疗的前列腺癌患者的疲劳症状有关。一项与乔治城大学华盛顿特区风湿病学系的合作研究(OHSR豁免#4966)探索了纤维肌痛患者在运动干预前后细胞因子谱和基因表达结果与疼痛和疲劳症状之间的关联。所有这些研究共收集了137条PAX基因表达分析管，313.5毫升血清和623.25毫升血浆样本，用于对94例患者(21例前列腺癌患者，69例健康志愿者，4例纤维肌痛患者)进行蛋白分析。

Four studies are actively recruiting to address the goal of the fatigue program. One study 09-NR-0088, "Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy" follows the fatigue symptoms of men with prostate cancer undergoing localized radiation therapy. Another study 09-NR-0131, "Fatigue in Healthy Individuals" explores fatigue in healthy volunteers. The study 10-NR-0128, "Relationship between Mitochondrial Dysfunction and Fatigue in Cancer Patients Following External Beam Radiation Therapy" specifically explores changes in the expression of mitochondrial genes that are associated with fatigue symptoms of prostate cancer patients receiving localized radiation therapy. A collaborative study with Georgetown University, Department of Rheumatology in Washington DC (OHSR Exempt #4966), explores the association between cytokine profile and gene expression findings with pain and fatigue symptoms of fibromyalgia patients before and after an exercise intervention. All these studies have collected a total of 137 PAX mRNA tubes for gene expression analysis, 313.5 mL of serum and 623.25 mL of plasma samples to run enzyme-linked immunosorbent assay for protein analyses for a total of 94 patients (21 prostate cancer patients, 69 healthy volunteers, 4 fibromyalgia patients).