Investigating Correlates and Therapeutics of Fatigue

疲劳的定义是缺乏活力和压倒性的疲劳感，这与悲伤或虚弱是不同的。在没有抑郁等心理共病的情况下，疲劳与许多神经疾病有关，包括多发性硬化症、帕金森氏病、运动神经元病、中风和脊髓灰质炎后综合征。疲劳的病理生理学仍然知之甚少。促炎细胞因子(TNFα、IL-1β、IL-6)的失调、HPA轴功能障碍、星形胶质细胞代谢紊乱以及神经递质(去甲肾上腺素、5-羟色胺)水平降低都被认为是其发病机制。抑郁症状和疲劳之间的关系可能是双向的，这意味着这些情况有共同的机制。与包括疲劳在内的神经植物症状相关的细胞因子也与抑郁症的高发病率相关，这一事实证明了这种联系。其他人反对共同机制假说，因为抑郁症状可能会通过药物治疗得到改善，而疲劳症状是抵抗力的。我们的调查使用标准化问卷对不同临床人群(健康志愿者、纤维肌痛患者、慢性疲劳综合征和抑郁症患者)的疲劳症状进行表征，并确定体力活动、疼痛、抑郁、疲劳灾难、压力和日间嗜睡是否在他们的疲劳体验中发挥作用。这项研究还将研究血浆细胞因子、基因表达和下丘脑-垂体-肾上腺轴(HPA)功能在这些人的疲劳症状中的潜在作用。从这次调查中收集的信息将有助于我们更好地了解疲劳的可能病因机制。

Fatigue is defined as a lack of energy and an overwhelming sense of tiredness that is distinguishable from sadness or weakness. Fatigue in the absence of psychological co-morbidities such as depression, has been associated with many neurological conditions, including multiple sclerosis, Parkinsons disease, motor neuron disease, stroke and post-polio syndromes. The pathophysiology of fatigue remains poorly understood. Dysregulation of pro-inflammatory cytokines (TNF alpha, IL-1 beta, IL-6), HPA axis dysfunction, disturbances of astroglia metabolism, and decreased levels of neurotransmitters (norepinephrine, serotonin) have all been proposed as mechanisms. The relationship between symptoms of depression and fatigue may be bidirectional, implying that these conditions have shared mechanisms. This association is evidenced by the fact that the cytokines associated with neurovegetative symptoms including fatigue are also associated with high rates of depression. Others argue against the shared mechanism hypothesis, as depressive symptoms may improve with pharmacotherapy, while symptoms of fatigue are resistive. Our investigation characterizes the symptoms of fatigue from different clinical populations (healthy volunteers, patients with fibromyalgia, chronic fatigue syndrome, and depression) using standardized questionnaires and determine if physical activity, pain, depression, fatigue catastrophizing, stress, and daytime sleepiness play a role in their fatigue experience. This study will also examine the potential role of plasma cytokines, gene expression, and hypothalamic-pituitary-adrenal axis (HPA) functioning in symptoms of fatigue in these individuals. Information collected from this investigation will be useful to improve our understanding of the possible etiologic mechanisms of fatigue.