GUDMAP- Database and Website

GUDMAP-数据库和网站

• 批准号: 8193553
• 负责人: Richard Alan Baldock
• 金额: $ 57.83万
• 依托单位: MEDICAL RES COUNCIL HUMAN GENETICS UNIT
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8193553
• 关键词: Adult; Anatomy; Apache Indians; Atlases; Bioinformatics; Biological Process; Biomedical Research; Cancer-Related Condition; Cells; Communities; Computer software; Data; Data Analyses; Data Collection; Data Security; Data Set; Databases; Defect; Development; Disease; Disease Association; Doctor of Philosophy; Education and Outreach; Extensible Markup Language; Gene Expression; Genes; Genitourinary system; Goals; Health; Homeostasis; Image; Image Analysis; Imagery; Imaging Device; Improve Access; In Situ; In Situ Hybridization; Inflammatory; Internet; Knowledge; Link; Maintenance; Manuals; Messenger RNA; Molecular; Mouse Strains; Mus; Ontology; Organ; Organism; Pathway Analysis; Pathway interactions; Pattern; Phenotype; Principal Investigator; Procedures; Process; Protocols documentation; Quality Control; RNA; RNA Sequences; Research; Resolution; Resources; Retrieval; Running; Secure; Services; Staging; System; Techniques; Three-Dimensional Image; Time; Tissues; Update; Urinary system; Vertebrates; cell type; comparative; crosslink; data sharing; design; disease phenotype; editorial; high throughput analysis; improved; indexing; interoperability; meetings; mutant; open source; operation; outreach; protein expression; protein metabolism; repository; tool; web services; web site

DESCRIPTION (provided by applicant): The goal of the Genitourinary Development Molecular Anatomy Project website and database (GUDMAP WebDB) is to deliver research-enabling data and knowledge to the biomedical research community on the molecular development of all organs within the genitourinary (GU) tract. GUDMAP WebDB provides curated and validated gene and protein expression data, links to disease and tools for analysis, each of which serve to improve our understanding of the biological processes that underpin normal and abnormal GU development, homeostasis, and disease processes. Defects in organs ofthe GU tract involve developmental, inflammatory, infectious, and cancer -related conditions are represent a growing health burden internationally. The primary goals maintain and extend the GUDMAP WebDB to a broader range of data pertinent to both GU development and disease. The core objective provides a repository for retrieval and analysis of GU data, additional depth will be accomplished by an outreach effort to capture data, knowledge and expertise using curators and the development of new interfaces and tools. Specific aims are: Aim 1: Development of Core Services - continued development to deliver robust editorial function with full online submission and tracking, outreach, extended data types, improved simple and advanced query interfaces, enhanced ontology, support for GUDMAP 2 Aim 2: Extension of Data and Resources - extend stage range, adult and non-murine systems, high- throughput sequencing data including RNA-seq and ChlP-seq tracks and summaries, multi-modal 2/3D image data, phenotype/disease associations, full online submission and annotation. Aim 3: Improvement of Bioinformatics and Analysis - extended cross-platform and comparative analysis, networks and pathways, manual and automated image analysis for phenotype. Aim 4; Enhancement of Integration and Interoperability - user interfaces for user-specific data-collections and analyses, extended resource links and cross-indexing (MGl/GXD), interfaces for DB interoperability (BioMArt, geneDas and web-services), Web 2.0 interfaces for configurable views, analysis and data sharing. PUBLIC HEALTH RELEVANCE: The GUDMAP project provides key data and knowledge of the development of the genito-urinary system in vertebrates which serve to develop a deep understanding of the biological processes which underpin normal, abnormal tissue development and potentially disease.

描述（由申请人提供）：泌尿生殖系统发育分子解剖学项目网站和数据库（GUDMAP WebDB）的目标是向生物医学研究界提供有关泌尿生殖系统（GU）内所有器官分子发育的研究数据和知识。GUDMAP WebDB提供经过整理和验证的基因和蛋白质表达数据、疾病链接和分析工具，每一个都有助于提高我们对支撑正常和异常GU发育、体内平衡和疾病过程的生物过程的理解。消化道器官缺陷涉及发育、炎症、感染和癌症相关疾病，是国际上日益增长的健康负担。主要目标是维护和扩展GUDMAP WebDB，以获得与GU发展和疾病相关的更广泛的数据。核心目标是提供一个检索和分析GU数据的储存库，通过利用管理员和开发新的界面和工具来获取数据、知识和专门知识的外联努力将进一步深入。目标1：核心服务的开发——继续开发提供强大的编辑功能，包括完整的在线提交和跟踪、扩展、扩展数据类型、改进的简单和高级查询接口、增强的本体、支持GUDMAP 2。数据和资源的扩展-扩展阶段范围，成人和非小鼠系统，高通量测序数据，包括RNA-seq和ChlP-seq轨迹和摘要，多模态2/3D图像数据，表型/疾病关联，完整的在线提交和注释。目标3：生物信息学和分析的改进-扩展跨平台和比较分析，网络和途径，表型的手动和自动图像分析。目标4;集成和互操作性的增强——用于用户特定数据收集和分析的用户界面，扩展资源链接和交叉索引（MGl/GXD），数据库互操作性的接口（BioMArt、geneDas和Web服务），用于可配置视图、分析和数据共享的Web 2.0接口。