GUDMAP- Database and Website

GUDMAP-数据库和网站

• 批准号: 8926966
• 负责人: Richard Alan Baldock
• 金额: $ 51.81万
• 依托单位: UNIVERSITY OF EDINBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8926966
• 关键词: 4D Imaging; Adult; Anatomy; Apache Indians; Atlases; Bioinformatics; Biological Process; Biomedical Research; Cancer-Related Condition; Cells; Communities; Computer software; Data; Data Analyses; Data Collection; Data Security; Data Set; Databases; Defect; Development; Disease; Doctor of Philosophy; Education and Outreach; Extensible Markup Language; Gene Expression; Genes; Genitourinary system; Goals; Health; High-Throughput Nucleotide Sequencing; Homeostasis; Image; Image Analysis; Imagery; Imaging Device; Improve Access; In Situ; In Situ Hybridization; Inflammatory; Internet; Knowledge; Link; Maintenance; Manuals; Messenger RNA; Molecular; Mouse Strains; Mus; Ontology; Organ; Organism; Pathway Analysis; Pathway interactions; Pattern; Phenotype; Principal Investigator; Procedures; Process; Protocols documentation; Quality Control; Research; Resolution; Resources; Retrieval; Running; Secure; Services; Staging; System; Techniques; Three-Dimensional Image; Time; Tissues; Update; Urinary system; Vertebrates; cell type; comparative; crosslink; data sharing; design; disease phenotype; editorial; improved; indexing; interoperability; meetings; mutant; open source; operation; outreach; protein expression; protein metabolism; repository; tool; transcriptome sequencing; web services; web site

DESCRIPTION (provided by applicant): The goal of the Genitourinary Development Molecular Anatomy Project website and database (GUDMAP WebDB) is to deliver research-enabling data and knowledge to the biomedical research community on the molecular development of all organs within the genitourinary (GU) tract. GUDMAP WebDB provides curated and validated gene and protein expression data, links to disease and tools for analysis, each of which serve to improve our understanding of the biological processes that underpin normal and abnormal GU development, homeostasis, and disease processes. Defects in organs ofthe GU tract involve developmental, inflammatory, infectious, and cancer -related conditions are represent a growing health burden internationally. The primary goals maintain and extend the GUDMAP WebDB to a broader range of data pertinent to both GU development and disease. The core objective provides a repository for retrieval and analysis of GU data, additional depth will be accomplished by an outreach effort to capture data, knowledge and expertise using curators and the development of new interfaces and tools. Specific aims are: Aim 1: Development of Core Services - continued development to deliver robust editorial function with full online submission and tracking, outreach, extended data types, improved simple and advanced query interfaces, enhanced ontology, support for GUDMAP 2 Aim 2: Extension of Data and Resources - extend stage range, adult and non-murine systems, high- throughput sequencing data including RNA-seq and ChlP-seq tracks and summaries, multi-modal 2/3D image data, phenotype/disease associations, full online submission and annotation. Aim 3: Improvement of Bioinformatics and Analysis - extended cross-platform and comparative analysis, networks and pathways, manual and automated image analysis for phenotype. Aim 4; Enhancement of Integration and Interoperability - user interfaces for user-specific data-collections and analyses, extended resource links and cross-indexing (MGl/GXD), interfaces for DB interoperability (BioMArt, geneDas and web-services), Web 2.0 interfaces for configurable views, analysis and data sharing.

描述（由申请人提供）：泌尿生殖发育分子解剖学项目网站和数据库 (GUDMAP WebDB) 的目标是向生物医学研究界提供有关泌尿生殖 (GU) 道内所有器官的分子发育的研究支持数据和知识。 GUDMAP WebDB 提供精心策划和验证的基因和蛋白质表达数据、疾病链接和分析工具，其中每一项都有助于提高我们对支持正常和异常 GU 发育、稳态和疾病过程的生物过程的理解。胃肠道器官的缺陷涉及发育、炎症、感染和癌症相关疾病，在国际上代表着日益增长的健康负担。主要目标是维护 GUDMAP WebDB 并将其扩展到更广泛的与 GU 发育和疾病相关的数据。核心目标提供一个用于检索和分析 GU 数据的存储库，通过使用策展人捕获数据、知识和专业知识以及开发新界面和工具的外展工作，将实现额外的深度。具体目标是： 目标 1：开发核心服务 - 持续开发提供强大的编辑功能，包括完整的在线提交和跟踪、外展、扩展数据类型、改进的简单和高级查询界面、增强本体、支持 GUDMAP 2 目标 2：数据和资源扩展 - 扩展阶段范围、成人和非小鼠系统、高通量测序数据，包括 RNA-seq 和 ChlP-seq 轨迹和摘要， 多模态 2/3D 图像数据、表型/疾病关联、完整在线提交和注释。 目标 3：生物信息学和分析的改进 - 扩展的跨平台和比较分析、网络和路径、表型的手动和自动图像分析。 目标4；集成和互操作性的增强 - 用于用户特定数据收集和分析的用户界面、扩展资源链接和交叉索引 (MGl/GXD)、数据库互操作性界面（BioMArt、geneDas 和 Web 服务）、用于可配置视图、分析和数据共享的 Web 2.0 界面。