nGUDMAP ??? Ontology, Database and Website Core

描述(申请人提供)：泌尿系慢性盆腔疼痛综合征(UCPPS)是一组综合征，包括痛性膀胱综合征(PBS)和慢性盆腔疼痛综合征(CPPS)。UCPPS对患者造成了巨大的影响和负担，这些患者一生中都患有相当大的发病率，生活质量显著下降。UCPPS的诊断和管理也很昂贵，2000年患者总支出估计为1.5亿美元。对慢性疼痛的感知是这些症状的一个定义特征。关于这些症状的原因以及疾病是如何和为什么发生的，人们知之甚少。为了更好地了解膀胱和前列腺的工作原理，以便更好地了解这些器官中的疾病是如何发生和发展的，人们已经做出了努力。然而，我们仍然对盆腔区域的神经元以及它们是如何发育和生长的知之甚少。NGUDMAP研究项目的目标是收集骨盆区域(负责我们感觉疼痛的方式)神经系统的数据。这些数据集中在骨盆区域神经元的细胞和分子水平的细节上。GUDMAP(生殖道发育分子解剖学项目)为生物研究人员提供了一个资源，其中包含了发育中的小鼠生殖道(肾脏、膀胱、生殖器官)系统的高质量基因表达数据。这包括一个发展中的泌尿生殖系统的本体论，它提供了基因表达可以被注释的基础。这基本上提供了一种简单的描述，说明不同的基因何时何地在生殖系统的不同部分发挥作用。NGUDMAP核心地图集汇编项目是现有GUDMAP资源的延伸，其主要目标是支持参与nGUDMAP的研究项目。它将提供这些项目成功注释其数据所需的必要本体更改。它将提供可供nGUDMAP研究项目使用的工具，以便将其数据轻松提交给GUDMAP资源。核心地图集汇编项目有5个主要目标。这些是：1.为解剖学本体论扩展方面的贡献项目提供专业知识和支持。这一点很重要，这样新的数据才能被正确和全面地注释。2.开发现有和新的软件，以提供工具(在线提交界面)，以便捐助项目可以轻松地将其数据提交给上级GUDMAP资源。这还将包括扩展现有的GUDMAP数据库(以便可以适当地存放新数据)和扩展GUDMAP网站，以便研究界可以访问和查看新的数据和图像。3.通过任命一名具有特定神经科学经验的新编辑，将加强编辑部现有的专门知识。这将确保对提交的数据实行强有力的质量控制政策。编辑部还将在数据提交的所有方面向捐款项目提供直接支助。4.条文 管理图像数据上传和存储到GUDMAP的系统(OMERO)。预计可能会有各种各样的图像类型通过向GUDMAP提供贡献的项目提交。该系统将与GUDMAP在线提交界面相结合，以便将图像、注释和实验数据全部捕获在一起。Omero系统还将提供图像发布、下载和分析工具。5.确保来自捐助项目的所有新数据都与GUDMAP相结合，确保可以通过GUDMAP网站上的基本和高级查询和浏览功能方便地获取这些数据。提供新的图像可视化和分析选项。从GUDMAP网站添加指向任何关键神经科学资源的新链接。

DESCRIPTION (provided by applicant): Urologic chronic pelvic pain syndromes (UCPPS) are a collection of syndromes that include both painful bladder syndrome (PBS) and chronic pelvic pain syndrome (CPPS). UCPPS has an enormous impact and burden on patients who suffer from considerable morbidity throughout their lives and a significant decrease in quality of life. The diagnosis and management of UCPPS is also expensive with overall patient spending estimated at $150million for the year 2000. The perception of chronic pain is a defining feature of these syndromes. Very little is understood about what causes these syndromes and how and why disease arises. Efforts have been made to gain a better understanding of how the bladder and prostate work, in order to better understand how disease in these organs is caused and progresses. However, we still know very little about the neurons in the pelvic region and how they develop and grow. The nGUDMAP research projects are aiming to gather data on the neuronal systems in the pelvic region (responsible for how we feel pain). This data is focused on the cells and molecular level detail of the neurons in the pelvic region. GUDMAP (GenitoUrinary Development Molecular Anatomy Project) provides a resource for the biological researcher that contains high-quality gene expression data for the developing mouse genitourinary (kidney, bladder, reproductive organs) system. This includes an ontology of the developing genitourinary system that provides the basis onto which gene expression can be annotated. This essentially provides a simple description of when and where different genes are functioning in different parts of the genitourinary system. The nGUDMAP Core Atlas Assembly Project is an extension of the existing GUDMAP resource, the main objective of which is supporting the research projects involved in nGUDMAP. It will provide the necessary ontology changes that are required by these projects to successfully annotate their data. It will provide tools that can be used by th nGUDMAP research projects to submit their data easily to the GUDMAP resource. There are 5 main aims of the Core Atlas Assembly Project. These are: 1. To provide expertise and support to the contributing projects in the extension of the anatomical ontology. This is important so that new data can be correct and comprehensively annotated. 2. Develop existing and new software to provide tools (online submission interface) so that contributing projects can easily submit their data to the parent GUDMAP resource. This will also include extension of the existing GUDMAP database (so new data can be appropriately housed) and extension of the GUDMAP website so new data and images are accessible and visible to the research community. 3. The existing expertise with in the Editorial Office will be strengthened by appointment of a new editor with specific neuroscience experience. This will ensure that the strong policy of quality control of submitted data is maintained. The Editorial Office will also provide direct support to contributing projects in all aspects of data submission. 4. Provision of a system (OMERO) that will manage the upload and storage of image data to GUDMAP. It is anticipated that there could be a wide-range of image types being submitted by contributing projects to GUDMAP. This system will be combined with the GUDMAP online submission interface so that images, annotations and experimental data are all captured together. The OMERO system will also provide tools for image publication, download and analysis. 5. Ensure that all new data from contributing projects is integrated with GUDMAP, making sure that it can be easily accessed through basic and advance queries and browse functions on the GUDMAP website. Provide new image visualization and analysis options. Add in new links from the GUDMAP website to any key neuroscience resources.