nGUDMAP ??? Ontology, Database and Website Core

描述（由申请人提供）：泌尿系统慢性盆腔疼痛综合征（UCPPS）是一系列综合征，包括膀胱疼痛综合征（PBS）和慢性盆腔疼痛综合征（CPPS）。UCPPS对患者产生了巨大的影响和负担，这些患者一生中发病率很高，生活质量显著下降。UCPPS的诊断和管理也很昂贵，2000年患者的总体支出估计为1.5亿美元。慢性疼痛的感知是这些综合征的一个决定性特征。人们对导致这些综合征的原因以及疾病如何和为何产生知之甚少。为了更好地了解这些器官的疾病是如何产生和发展的，人们已经做出了努力，以更好地了解膀胱和前列腺是如何工作的。然而，我们对骨盆区域的神经元及其如何发育和生长仍然知之甚少。nGUDMAP研究项目的目标是收集骨盆区域（负责我们如何感受疼痛）神经系统的数据。这些数据集中在骨盆区域神经元的细胞和分子水平细节上。GUDMAP（泌尿生殖系统发育分子解剖项目）为生物学研究者提供了一个包含发育中的小鼠泌尿生殖系统（肾、膀胱、生殖器官）高质量基因表达数据的资源。这包括一个发展中的泌尿生殖系统的本体论，它提供了基因表达可以被注释的基础。这基本上提供了一个简单的描述，不同的基因在何时何地在泌尿生殖系统的不同部分起作用。nGUDMAP核心地图集汇编项目是现有GUDMAP资源的扩展，其主要目标是支持nGUDMAP中涉及的研究项目。它将提供必要的本体更改，这些更改是这些项目成功注释其数据所必需的。它将提供一些工具，供nGUDMAP研究项目使用，方便地向GUDMAP资源提交数据。核心地图集组装项目有5个主要目标。它们是：1；在解剖学本体的扩展中为贡献项目提供专业知识和支持。这一点很重要，以便对新数据进行正确和全面的注释。2. 开发现有的和新的软件，以提供工具（在线提交界面），以便贡献项目可以轻松地将其数据提交到父GUDMAP资源。这还将包括扩展现有的GUDMAP数据库（以便可以适当地容纳新数据）和扩展GUDMAP网站，以便研究社区可以访问和看到新的数据和图像。3. 编辑部现有的专业知识将通过任命一位具有特定神经科学经验的新编辑得到加强。这将确保对提交的数据进行强有力的质量控制。编辑部还将在数据提交的各个方面为投稿项目提供直接支持。4. 条款

DESCRIPTION (provided by applicant): Urologic chronic pelvic pain syndromes (UCPPS) are a collection of syndromes that include both painful bladder syndrome (PBS) and chronic pelvic pain syndrome (CPPS). UCPPS has an enormous impact and burden on patients who suffer from considerable morbidity throughout their lives and a significant decrease in quality of life. The diagnosis and management of UCPPS is also expensive with overall patient spending estimated at $150million for the year 2000. The perception of chronic pain is a defining feature of these syndromes. Very little is understood about what causes these syndromes and how and why disease arises. Efforts have been made to gain a better understanding of how the bladder and prostate work, in order to better understand how disease in these organs is caused and progresses. However, we still know very little about the neurons in the pelvic region and how they develop and grow. The nGUDMAP research projects are aiming to gather data on the neuronal systems in the pelvic region (responsible for how we feel pain). This data is focused on the cells and molecular level detail of the neurons in the pelvic region. GUDMAP (GenitoUrinary Development Molecular Anatomy Project) provides a resource for the biological researcher that contains high-quality gene expression data for the developing mouse genitourinary (kidney, bladder, reproductive organs) system. This includes an ontology of the developing genitourinary system that provides the basis onto which gene expression can be annotated. This essentially provides a simple description of when and where different genes are functioning in different parts of the genitourinary system. The nGUDMAP Core Atlas Assembly Project is an extension of the existing GUDMAP resource, the main objective of which is supporting the research projects involved in nGUDMAP. It will provide the necessary ontology changes that are required by these projects to successfully annotate their data. It will provide tools that can be used by th nGUDMAP research projects to submit their data easily to the GUDMAP resource. There are 5 main aims of the Core Atlas Assembly Project. These are: 1. To provide expertise and support to the contributing projects in the extension of the anatomical ontology. This is important so that new data can be correct and comprehensively annotated. 2. Develop existing and new software to provide tools (online submission interface) so that contributing projects can easily submit their data to the parent GUDMAP resource. This will also include extension of the existing GUDMAP database (so new data can be appropriately housed) and extension of the GUDMAP website so new data and images are accessible and visible to the research community. 3. The existing expertise with in the Editorial Office will be strengthened by appointment of a new editor with specific neuroscience experience. This will ensure that the strong policy of quality control of submitted data is maintained. The Editorial Office will also provide direct support to contributing projects in all aspects of data submission. 4. Provision of a system (OMERO) that will manage the upload and storage of image data to GUDMAP. It is anticipated that there could be a wide-range of image types being submitted by contributing projects to GUDMAP. This system will be combined with the GUDMAP online submission interface so that images, annotations and experimental data are all captured together. The OMERO system will also provide tools for image publication, download and analysis. 5. Ensure that all new data from contributing projects is integrated with GUDMAP, making sure that it can be easily accessed through basic and advance queries and browse functions on the GUDMAP website. Provide new image visualization and analysis options. Add in new links from the GUDMAP website to any key neuroscience resources.