nGUDMAP ??? Ontology, Database and Website Core

nGUDMAP ???

• 批准号: 8636552
• 负责人: Richard Alan Baldock
• 金额: $ 29.16万
• 依托单位: UNIVERSITY OF EDINBURGH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-23 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8636552
• 关键词: Affect; Anatomy; Appointment; Archives; Atlases; Biological; Bladder; Cells; Clinical; Collaborations; Collection; Communities; Complement; Computer software; Data; Data Set; Databases; Development; Diagnosis; Disease; Ensure; Gene Expression; Genitourinary system; Goals; Housing; Image; Image Analysis; Imagery; Imaging Device; In Situ Hybridization; Interstitial Cystitis; Kidney; Lead; Link; Manufacturer Name; Messenger RNA; Microscopy; Modification; Molecular; Morbidity - disease rate; Mus; Nerve; Neurons; Neurosciences; Online Mendelian Inheritance In Man; Ontology; Organ; Pain; Parents; Patients; Pelvic Pain; Pelvis; Perception; Pharmaceutical Preparations; Policies; Positioning Attribute; Process; Prostate; Publications; Quality Control; Quality of life; Reading; Research; Research Personnel; Research Project Grants; Resolution; Resources; Sensory Receptors; Stream; Symptoms; Syndrome; System; Technology; Three-Dimensional Imaging; Time; Update; Woman; Work; base; body system; chronic pain; chronic pelvic pain; data integration; editorial; experience; gene function; image archival system; image processing; image visualization; men; novel; open source; pain receptor; pre-clinical research; public health relevance; reproductive; research study; tool; urologic; web based interface; web site

DESCRIPTION (provided by applicant): Urologic chronic pelvic pain syndromes (UCPPS) are a collection of syndromes that include both painful bladder syndrome (PBS) and chronic pelvic pain syndrome (CPPS). UCPPS has an enormous impact and burden on patients who suffer from considerable morbidity throughout their lives and a significant decrease in quality of life. The diagnosis and management of UCPPS is also expensive with overall patient spending estimated at $150million for the year 2000. The perception of chronic pain is a defining feature of these syndromes. Very little is understood about what causes these syndromes and how and why disease arises. Efforts have been made to gain a better understanding of how the bladder and prostate work, in order to better understand how disease in these organs is caused and progresses. However, we still know very little about the neurons in the pelvic region and how they develop and grow. The nGUDMAP research projects are aiming to gather data on the neuronal systems in the pelvic region (responsible for how we feel pain). This data is focused on the cells and molecular level detail of the neurons in the pelvic region. GUDMAP (GenitoUrinary Development Molecular Anatomy Project) provides a resource for the biological researcher that contains high-quality gene expression data for the developing mouse genitourinary (kidney, bladder, reproductive organs) system. This includes an ontology of the developing genitourinary system that provides the basis onto which gene expression can be annotated. This essentially provides a simple description of when and where different genes are functioning in different parts of the genitourinary system. The nGUDMAP Core Atlas Assembly Project is an extension of the existing GUDMAP resource, the main objective of which is supporting the research projects involved in nGUDMAP. It will provide the necessary ontology changes that are required by these projects to successfully annotate their data. It will provide tools that can be used by th nGUDMAP research projects to submit their data easily to the GUDMAP resource. There are 5 main aims of the Core Atlas Assembly Project. These are: 1. To provide expertise and support to the contributing projects in the extension of the anatomical ontology. This is important so that new data can be correct and comprehensively annotated. 2. Develop existing and new software to provide tools (online submission interface) so that contributing projects can easily submit their data to the parent GUDMAP resource. This will also include extension of the existing GUDMAP database (so new data can be appropriately housed) and extension of the GUDMAP website so new data and images are accessible and visible to the research community. 3. The existing expertise with in the Editorial Office will be strengthened by appointment of a new editor with specific neuroscience experience. This will ensure that the strong policy of quality control of submitted data is maintained. The Editorial Office will also provide direct support to contributing projects in all aspects of data submission. 4. Provision of a system (OMERO) that will manage the upload and storage of image data to GUDMAP. It is anticipated that there could be a wide-range of image types being submitted by contributing projects to GUDMAP. This system will be combined with the GUDMAP online submission interface so that images, annotations and experimental data are all captured together. The OMERO system will also provide tools for image publication, download and analysis. 5. Ensure that all new data from contributing projects is integrated with GUDMAP, making sure that it can be easily accessed through basic and advance queries and browse functions on the GUDMAP website. Provide new image visualization and analysis options. Add in new links from the GUDMAP website to any key neuroscience resources.

描述（由申请人提供）：泌尿系统慢性盆腔疼痛综合征（UCPPS）是一组综合征，包括膀胱疼痛综合征（PBS）和慢性盆腔疼痛综合征（CPPS）。UCPPS对患者产生了巨大的影响和负担，这些患者一生中发病率很高，生活质量显着下降。UCPPS的诊断和治疗费用也很昂贵，2000年患者的总支出估计为1.5亿美元。慢性疼痛的感知是这些综合征的定义特征。人们对这些综合征的原因以及疾病如何以及为什么会出现知之甚少。 已经做出努力以更好地了解膀胱和前列腺如何工作，以便更好地了解这些器官中的疾病是如何引起和发展的。然而，我们对骨盆区域的神经元以及它们如何发育和生长仍然知之甚少。nGUDMAP研究项目旨在收集骨盆区域神经系统的数据（负责我们如何感受疼痛）。这些数据集中在骨盆区域神经元的细胞和分子水平细节上。 GUDMAP（GenitoUrinary Development Molecular Anatomy Project）为生物研究人员提供了一个资源，其中包含发育中的小鼠泌尿生殖系统（肾脏，膀胱，生殖器官）的高质量基因表达数据。这包括一个发育中的泌尿生殖系统的本体论，它提供了基因表达可以被注释的基础。这基本上提供了一个简单的描述，不同的基因在何时何地在泌尿生殖系统的不同部位发挥作用。 nGUDMAP核心地图集组装项目是现有GUDMAP资源的扩展，其主要目标是支持nGUDMAP中涉及的研究项目。它将提供这些项目成功注释其数据所需的必要本体更改。它将提供工具，供nGUDMAP研究项目使用，以便将其数据轻松提交到GUDMAP资源。 核心地图集组装项目有5个主要目标。这些是： 1.提供专业知识和支持的贡献项目在延长解剖 本体论这很重要，以便新数据能够正确并全面注释。 2.开发现有的和新的软件，以提供工具（在线提交界面）， 项目可以轻松地将其数据提交到父GUDMAP资源。这也将包括扩展 现有的GUDMAP数据库（以便适当地容纳新数据）和 GUDMAP网站，使新的数据和图像可供研究界访问和可见。 3.任命一名新编辑将加强编辑处现有的专门知识 有着丰富的神经科学经验这将确保质量控制的强有力的政策， 已提交的数据将得到维护。编辑办公室还将直接支持投稿项目 在数据提交的各个方面。 4.提供 系统（OMERO）将管理图像数据上传和存储到GUDMAP。它 预计贡献项目提交的图像类型可能范围很广 关于GUDMAP该系统将与GUDMAP在线提交界面相结合， 图像、注释和实验数据都被一起捕获。OMERO系统还将提供图像发布、下载和分析工具。 5.确保来自贡献项目的所有新数据与GUDMAP集成，确保它可以 通过GUDMAP网站上的基本和高级查询和浏览功能轻松访问。 提供新的图像可视化和分析选项。从GUDMAP网站添加新链接， 任何重要的神经科学资源