Imaging Guided Surgery using Fluorescently Labeled Cetuximab

描述(由申请人提供)：来自我们实验室和其他实验室的证据表明，荧光标记抗体具有测量微观疾病的潜力，以指导外科干预临床前模型。我们提供了新的数据，证明了荧光标记的抗EGFR抗体在非人类灵长类动物中的安全性。我们建议在手术室使用荧光标记的西妥昔单抗进行临床试验，以检测亚临床癌症，现有的影像设备用于指导头颈部癌症的手术切除。拟议的试验已于2013年9月获得IRB和IND的批准。

DESCRIPTION (provided by applicant): Evidence from our lab and others has demonstrated the potential of fluorescently labeled antibodies to measure microscopic disease to guide surgical intervention preclinical models. We present novel data demonstrating safety of the fluorescently labeled anti- EGFR antibody in non-human primates. We propose a clinical trial with fluorescently labeled cetuximab to detect subclinical cancer in the operating room existing imaging equipment to guide surgical resection of head and neck cancer. The proposed trial has received IRB and IND approval in September 2013.