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Cellular and Molecular Tumorsuppressor Processes Uncovered by DNA Fork Protection

DNA 叉保护揭示细胞和分子肿瘤抑制过程

基本信息

批准号：
8827169
负责人：
Katharina Schlacher
金额：
$ 20.03万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8827169
关键词：
Accounting Aplastic Anemia Area Award BRCA1 gene BRCA2 gene CCL4 gene Cell physiology Cells DNA DNA Damage DNA Double Strand Break DNA Repair DNA biosynthesis DNA replication fork Data Disease Double Strand Break Repair Engineering Environment Faculty Fanconi Anemia-BRCA Pathway Fanconi anemia protein Fanconi&apos s Anemia Filament Funding Genes Genomic Instability Genomics Goals Health Heart Hereditary Breast Carcinoma High-Risk Cancer Knowledge Malignant Neoplasms Mammary Neoplasms Mediating Memorial Sloan-Kettering Cancer Center Mentors Mentorship Methods Molecular Mutate Pathway interactions Patients Positioning Attribute Process Proteins Public Health RAD51C gene Replication-Associated Process Research Research Personnel Role Secure Structure Technology Testing Therapeutic Training Tumor Biology Tumor Cell Biology Tumor Suppressor Proteins United States National Institutes of Health anticancer research career crosslink experience frontier genome integrity homologous recombination improved insight malignant breast neoplasm meetings neoplastic cell novel nuclease ovarian neoplasm pancreatic neoplasm paralogous gene prevent repaired stem cell biology symposium tumor tumorigenesis

项目摘要

DESCRIPTION (provided by applicant): The applicant, Katharina Schlacher, is committed to a lifelong academic career and aims to become an independent investigator and enabling mentor at the frontier of cancer research in the field of replication fork protection. Katharina proposes three-year plan that will optimally equip her to becoming a successful independent research investigator in this challenging funding environment. The proposed project seeks to study cellular and molecular processes of replication fork protection by tumor-suppressor. The specific aims of the project are as follows: Aim1 Investigating replication fork instability in tumor cells, Aim2 Testing FA-mediated replisome stability, and Aim3 Determining RAD51 paralog tumor suppressor functions during fork protection. The proposed Aims will obtain critical knowledge on the impact of this new area of research to tumor biology, to understand its role in tumor cells and to initiate detailed insights into fork protection. This project will strengthen her abilities nd this new research area that is at the heart of her independent career, during which she aspires to decipher the mechanism of replication fork protection, identify new players of this pathway and open doors to understanding its implications with regards to stem cell biology and therapeutic strategies Under the mentorship of Dr. Maria Jasin (MSKCC) and co-mentor Dr. Hong Wu (UCLA), the candidate will meet regularly with her mentors, interact with other pertinent experts in the field, and supplement her training with structured meetings, conferences, and coursework. The award will produce sufficient preliminary data for independent funding applications, and enable her to acquire key technical knowledge, experience, and data needed to build and substantiate this new research area, to successfully jump-start her independent career and to secure an independent faculty position in health-related research. She will gain key extra and complementary experience in IPOND, Rad51 paralogs, and Talen technology for genomic engineering as well as on replication fork instability in mammary, ovarian and pancreatic tumor cells. Dr. Schlacher and her mentors thus view this project as a critical enabling opportunity for her to meet the challenges of her research goals and aspirations.

描述（由申请人提供）：申请人Katharina Schlacher致力于终身学术生涯，目标是成为复制叉保护领域癌症研究前沿的独立研究者和授权导师。Katharina提出了一个三年计划，这将使她在这个充满挑战的资助环境中成为一名成功的独立研究研究者。本项目旨在研究肿瘤抑制因子保护复制叉的细胞和分子过程。该项目的具体目的如下：目的1研究肿瘤细胞复制叉的不稳定性；