Early Detection and Prevention of Mild Cognitive Impairment due to Cerebrovascular Disease

描述(申请人提供)：临床上需要区分老年人认知障碍的不同原因，以便进行早期诊断和旨在改善患者预后的治疗干预，这一需求尚未得到满足。肯塔基大学阿尔茨海默病中心(UK-ADC)一直处于研究非AD MCI最常见原因的前沿，表明超过三分之二的老年患者患有有害影响认知的非AD大脑疾病。我们选择关注脑血管疾病所致的MCI(MCI-CVD)。这项应用侧重于定义MCI-CVD的病理基础和特定危险因素的关系，使用成像、血清和脑脊液生物标记物开发MCI-CVD的临床诊断标准，这也将允许对MCI-CVD的治疗干预进行纵向评估和评估。因此，目前的应用代表了一个全面的板凳到床边翻译计划，旨在直接增加我们对当今老年人口认知能力下降的主要原因的理解和影响。多学科团队代表了该领域的领导者，他们在MCI领域拥有经过证实的科学成就和合作企业的历史。项目目标的成功完成将使人们能够对MCI-CVD有一个全面的了解，并有可能对当今国家面临的主要医疗危机之一产生巨大影响。

DESCRIPTION (provided by applicant): There is a great unmet need to distinguish clinically between the different causes of cognitive impairment in elderly individuals for the sake of early diagnosis and therapeutic intervention designed to improve outcomes for patients. The University of Kentucky Alzheimer's Disease Center (UK-ADC) has been at the forefront of studying the most prevalent causes of Non-AD MCI, demonstrating that over two-thirds of elderly patients have non-AD brain conditions that deleteriously affect cognition. We have chosen to focus on MCI due to cerebrovascular disease (MCI-CVD). This application focuses on defining the pathological underpinnings and relationships of specific risk factors to MCI-CVD, developing clinical diagnostic criteria for MCI-CVD using imaging, serum, and CSF biomarkers that will also allow longitudinal evaluation and assessment of therapeutic interventions in MCI-CVD. As such, the current application represents a comprehensive bench-to-bedside translational program designed to directly increase our understanding of and impact the major cause of cognitive decline in the elderly population today. The multidisciplinary team represents leaders in the field with proven track histories of scientific accomplishments and collaborative enterprise in the area of MCI. Successful completion of project aims will allow an integrated understanding of MCI-CVD with the potential for tremendous impact on one of the major healthcare crises facing the nation today.