Vpu inhibits NK cell function through down regulation of NTB-A

Vpu 通过下调 NTB-A 抑制 NK 细胞功能

• 批准号: 8281825
• 负责人: Edward Barker
• 金额: $ 35.09万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-25 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8281825
• 关键词: Activated Natural Killer Cell; Antigens; Antiviral Agents; B-Lymphocytes; Binding; CD4 Positive T Lymphocytes; Cell Degranulation; Cell Line; Cell membrane; Cell physiology; Cell surface; Cells; Cytolysis; Cytoplasmic Granules; Cytoplasmic Tail; Detection; Down-Regulation; Effectiveness; Event; Family; HIV; HIV Infections; HIV-1; HLA-A gene; Histocompatibility Antigens Class I; Human; Immune; Immune response; Immune system; Immunologic Surveillance; Individual; Infection; K-562; Knowledge; Lead; Ligands; Lymphocyte; Lytic; Major Histocompatibility Complex; Methods; NK Cell Activation; NK cell receptor NKB1; Natural Killer Cells; Proteins; Receptor Activation; Reporting; SIV; Signal Transduction; Stream; Subfamily lentivirinae; Surface; T-Lymphocyte; TRAPP transport protein particle; Testing; Transmembrane Domain; Virus; insight; mutant; novel therapeutic intervention; phospholipase C gamma; prevent; protein transport; receptor; response; trans-Golgi Network; treatment strategy