Nanotechnology Based Infection Control for Ventricular Assist Devices

描述（由申请人提供）：在过去的五十年里，全人工心脏技术中感染和血栓形成的控制一直备受关注。即使是完全植入式全人工心脏，感染控制也是必要的，因为患者仍然需要经皮导管来收集植入后的血流动力学数据。在与NIH/NHLBI的第一阶段合同中，ND Life和匹兹堡大学开发了一种基于纳米技术的高效抗感染涂层系统，可以很容易地应用于心室辅助装置（VAD）的传动系统的治疗。探索了一种新的绿色工艺，将银纳米粒子在第一阶段包覆在涤纶上。不可逆地固定在涤纶上的银纳米颗粒显示出在阶段I中细菌挑战的显著减少。在第二阶段，ND Life和匹兹堡大学将通过体外和体内研究，通过一种新的绿色加工技术优化基于纳米技术的抗菌涂层系统。我们在此提出的系统将为VAD传动系统提供一种简单而高效的抗感染涂层技术，与广泛的其他植入式医疗器械相关。 公共卫生相关性：在第二阶段开发的技术将为广泛的植入式医疗器械以及VAD的传动系统提供简单而高效的抗感染涂层技术。将利用该技术的一些具体领域将包括导管、医用绷带、用于烧伤和伤口治疗的绷带、用于呼吸系统的膜、用于透析、化疗等辅助端口的袖带，用于水净化的膜和用于空气净化的膜。

DESCRIPTION (provided by applicant): Control of infection and thrombosis in total artificial heart technology has been of great concern for the last five decades. Even for totally implantable total artificial hearts, infection control is necessary because patients still need percutaneous lines for collecting post-implant hemodynamic data. During the Phase I contract with NIH/NHLBI, ND Life and University of Pittsburgh developed a highly effective anti-infection coating system based on nanotechnology that can be easily applied to the treatment of drivelines for ventricular assist devices (VADs). A novel green processing technique has been explored to immobilize silver nanoparticles on Dacron in Phase I. Irreversibly immobilized silver nanoparticles on Dacron showed significant reduction of bacterial challenges in Phase I. In the Phase II, ND Life and University of Pittsburgh will optimize the nanotechnology-based antimicrobial coating systems by a novel green processing technique through in vitro and in vivo studies. The system we propose here will provide a simple and highly effective anti-infection coating technology for VAD drivelines, with relevance to a broad range of other implantable medical devices. PUBLIC HEALTH RELEVANCE: The technology to be developed in Phase II will result in a simple and highly effective anti- infection coating technology for a broad range of implantable medical devices in addition to drivelines for VADs. Some specific areas that would utilize this technology would include catheters, medical bandages, bandages for burn and wound treatments, membranes for respiratory systems, cuffs for ancillary ports for dialysis, chemotherapy etc., membranes for water purification, and membranes for air purification.