Postdoctoral Research Training in Biotherapy of Cancer

描述(由申请人提供)：这项建议是为外科住院医师和外科肿瘤学研究员提供的与生物疗法相关的转化研究的第一次更新培训计划。其目标是利用以下目标培养学术外科肿瘤学家：(1)招聘对外科肿瘤学感兴趣的有前途的外科医生，他们致力于与癌症生物治疗相关的学术外科肿瘤学；(2)提供专门的研究生课程，以增强他们在分子生物学、免疫学、生物化学、细胞生物学、遗传学和临床试验方面的知识，因为它与癌症和翻译研究有关；以及(3)通过与知名导师的合作，提供深入接触基本研究技能的机会。我们有一群竞争激烈的外科住院医生和外科肿瘤学研究员。申请者包括对外科肿瘤学感兴趣的匹兹堡大学外科住院医生，匹兹堡大学的外科肿瘤学研究员，以及对生物疗法研究感兴趣的其他项目的外科医生。该计划每年将资助三名外科医生。他们被提供了实验室的摘要，并被鼓励选择他们最感兴趣的实验室。我们的团队对生物疗法有着长期的兴趣和专业知识，我们建议将这一优势传递给 这些实习生。提供了五个明确的研究领域：1)免疫治疗；2)细胞因子治疗；3)基因治疗；4)靶向分子治疗；5)基因组学和蛋白质组学。导师在每个领域内分组，每个领域的一名代表在管理委员会中。培训经验将包括正式的课程工作、研讨会、期刊俱乐部和基础实验室研究。基础实验室研究将构成培训经验的主要部分。学员每年都将参加研究生院关于分子生物学、免疫学、生物化学、细胞生物学、遗传学和临床试验的原理和技术的课程，以及负责任的研究指导课程。学员将进入导师实验室，为期两年，如果得到管理委员会的批准，还可以选择接受第三年的培训。导师每6个月对受训人员进行一次评估，并在一年两次的行政委员会会议期间将评估结果传达给行政委员会。委员会会议结束后，受训者将与项目总监会面，届时受训者将被要求评估他/她在导师实验室的经验。在研究奖学金结束时，每个受训者需要一份两页的书面总结，评估他们的总体培训经验。虽然这个项目相对较新，但教职员工和实习生的反馈一直很好，学术生产率也很高。

DESCRIPTION (provided by applicant): This proposal is for the first renewal of a training program for surgical residents and surgical oncology fellows in translational research related to biologic therapies. The objective is to develop academic surgical oncologists using the following aims: (1) Recruit highly promising surgeons interested in surgical oncology, who are committed to a career in academic surgical oncology relevant to the biologic therapy of cancer, (2) Provide specific graduate course work to enhance their knowledge in molecular biology, immunology, biochemistry, cell biology, genetics, and clinical trials, as it relates to cancer and translationa research and (3) Provide an in-depth exposure to basic research skills by working with well-established mentors. We have a highly competitive group of surgical residents and surgical oncology fellows. Applicants include University of Pittsburgh surgical residents who are interested in surgical oncology, surgical oncology fellows from the University of Pittsburgh, and surgeons from other programs who are interested in biologic therapy research. Three surgeons will be supported by the program each year. They are provided a summary of the laboratories and encouraged to choose the lab that most interests them. Our group has a long standing interest and expertise in biologic therapies, and it is this strength that we propose to pass on to these trainees. Five defined research areas are offered: 1) Immunotherapy; 2) Cytokine Therapy; 3) Gene therapy; 4) Targeted Molecular Therapy; and 5) Genomics and Proteomics. Mentors are grouped within each field and a representative of each field is on the administrative committee. The training experience will consist of formal course work, seminars, journal clubs, and basic laboratory research. Basic laboratory research will form the bulk of the training experience. The trainees will all participate in graduate school courses on the principles and techniques of molecular biology, immunology, biochemistry, cell biology, genetics, and clinical trials, as well as courses on the responsible conduct of research each year. The trainees will enter a mentor's laboratory for two years, with an optional third year of training if approved by the Administrative Committee. The mentor evaluates the trainee every 6 months and communicates this evaluation to the Administrative Committee during the biannual Administrative Committee meeting. Following the Committee meeting, the trainee meets with the Program Director, at which time the trainee will be asked to evaluate his/her experience in the mentor's laboratory. A two-page written summary by each trainee evaluating their overall training experience is required at the conclusion of the research fellowship. While this program is relatively new, the feedback from the faculty and trainees has been excellent, and the academic productivity has been significant.