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Targeted investigation of tissue specific oxidative stress in the etiology of ALS

Targeted investigation of tissue specific oxidative stress in the etiology of ALS
ALS 病因中组织特异性氧化应激的针对性研究
批准号：
8195925
负责人：
HOLLY VAN REMMEN
金额：
$0.0万
依托单位：
SOUTH TEXAS VETERANS HEALTH CARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-04-01 至 2014-03-31
来源：
https://reporter.nih.gov/project-details/8195925
关键词：
ActinsAffectAllelesAmyotrophic Lateral SclerosisAntioxidantsAstrocytesBody Weight decreasedBreedingCellsCessation of lifeClinical TrialsCoupledDNADiseaseDisease ProgressionEnzymesEtiologyExcisionF2-IsoprostanesGastrocnemius MuscleGenetic Crossing OverGlial Fibrillary Acidic ProteinGulf WarHumanITGAM geneIncidenceIndividualInterventionInvestigationKnock-outKnockout MiceLaboratoriesLipid PeroxidationLipid PeroxidesLipidsLongevityMeasuresMediatingMediator of activation proteinMembraneMicrogliaMotor NeuronsMusMuscleMuscle WeaknessMuscular AtrophyMutant Strains MiceNeurodegenerative DisordersNeurogliaNeurologicNeuronsOnset of illnessOxidative StressParalysedPathogenesisPathologyPatientsPlayPopulationProteinsRelative (related person)RestRoleSkeletal MuscleSpinal CordSpinal cord injuryTestingTherapeutic InterventionTissuesTransgenesTransgenic MiceVeteransadductcell typedesigneffective therapyend stage diseasemotor neuron degenerationmouse modelmutantnerve supplyneuromuscularneuron lossnovel strategiesoxidationoxidative damagepatient populationphospholipid-hydroperoxide glutathione peroxidaserecombinaseresponseskeletaltherapeutic target

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会议论文
A novel role for oxidized lipid mediators as effectors of muscle atrophy and weakness in aging
A novel role for oxidized lipid mediators as effectors of muscle atrophy and weakness in aging
51st Annual Meeting of the American Aging Association
  • 批准号：
    10602831
  • 项目类别：
  • 资助金额：
    $5.0万
  • 财政年份：
    2022
  • 负责人：
    HOLLY VAN REMMEN
  • 依托单位：
    AMERICAN AGING ASSOCIATION, INC.
Testing OKN-007 as a potential intervention for ALS
  • 批准号：
    10513312
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    2021
  • 负责人：
    HOLLY VAN REMMEN
  • 依托单位：
    OKLAHOMA CITY VA MEDICAL CENTER
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