Lipoic Acid Therapy for Experimental Autoimmune Encephalomyelitis

硫辛酸治疗实验性自身免疫性脑脊髓炎

• 批准号: 7919383
• 负责人: Dennis Neil Bourdette
• 金额: --
• 依托单位: PORTLAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919383
• 关键词: Acute; Animal Model; Anti-Inflammatory Agents; Anti-inflammatory; Attention; Axon; Brain; Caring; Cell surface; Cells; Chronic; Clinical Data; Clinical Trials; Coupled; Cyclic AMP; Data; Demyelinating Diseases; Demyelinations; Dependence; Development; Disabled Persons; Disease; Dose; EP4 receptor; Endothelial Cells; Enzymes; Experimental Autoimmune Encephalomyelitis; FDA approved; Fluorescence Resonance Energy Transfer; Funding; Galectin 3; Generations; Health; Healthcare; ITGAM gene; Image; Immunofluorescence Immunologic; In Vitro; Individual; Inflammation; Inflammation Mediators; Inflammatory; Injection of therapeutic agent; Injury; Interferon Type II; Interferons; Intervention; Knock-out; Knockout Mice; Lesion; Life; Lipopolysaccharides; Lymphocyte; MHC Class II Genes; Measures; Microglia; Mission; Mitochondria; Modeling; Multiple Sclerosis; Multiple Sclerosis Lesions; Mus; Natural Killer Cells; Neuraxis; Neurologic; Nitric Oxide; Oxidation-Reduction; Pathogenesis; Patients; Pensions; Peripheral Blood Mononuclear Cell; Pharmaceutical Preparations; Production; Progressive Disease; Prostaglandins G; Regulatory Pathway; Relapse; Reporter; Reporting; Research; Research Project Grants; Services; Source; Staging; T-Lymphocyte; TNF gene; Technology; Testing; Therapeutic Effect; Thioctic Acid; Tumor Necrosis Factor-alpha; Up-Regulation; Veterans; Wild Type Mouse; Work; axonal degeneration; base; cell motility; cofactor; cost; cost effective; cytokine; dihydrolipoic acid; disability; disabling disease; effective therapy; health care service utilization; human WFDC2 protein; in vivo; inhibitor/antagonist; insight; knowledge base; migration; pre-clinical; prevent; prostaglandin EP2 receptor; public health relevance; receptor; research study; white matter