Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response

雌激素受体在狼疮炎症反应调节剂中的作用

• 批准号: 7904900
• 负责人: Gary S Gilkeson
• 金额: --
• 依托单位: RALPH H JOHNSON VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7904900
• 关键词: Address; Affect; Agonist; Anti-Inflammatory Agents; Anti-inflammatory; Antigen-Antibody Complex; Area; Autoantibodies; Autoimmune Diseases; B-Cell Activation; B-Lymphocytes; Backcrossings; Binding; Biological Preservation; Bone Marrow Transplantation; CCL2 gene; Calcineurin; Caring; Cell Count; Cell Line; Cell Nucleus; Cells; Clinic; Congenic Mice; Development; Disease; Epigenetic Process; Estrogen Receptor alpha; Estrogen Receptors; Estrogens; Family; Female; Funding; Gender; Genes; Genotype; Glomerulonephritis; Gonadal Steroid Hormones; Hormone Receptor; IL6 gene; Immune; Immune response; Immunity; Immunoglobulin G; In Vitro; Inflammation; Inflammatory Response; Kidney; Kidney Diseases; Kidney Failure; Knock-out; Ligand Binding; Ligands; Lupus; Lupus Nephritis; Mediating; Mediator of activation protein; Medical; Minority; Molecular; Mus; NZW Mouse; Nuclear Hormone Receptors; Nuclear Translocation; Organ; Pathogenesis; Pathologic; Pathway interactions; Patients; Phosphorylation; Physiological; Population; Prevalence; Production; Promoter Regions; Proteinuria; Publications; Receptor Signaling; Renal function; Research; Response Elements; Role; SLEB1 gene; Serum; Sex Characteristics; Sex Chromosomes; Signal Transduction; Small Interfering RNA; Somatic Mutation; Systemic Lupus Erythematosus; T-Lymphocyte; TLR3 gene; Testing; Tissues; Toll-Like Receptor 2; Toll-like receptors; Tumor Necrosis Factor-alpha; Veterans; Woman; X Inactivation; abstracting; anti-dsDNA antibodies; base; cell type; congenic; expectation; human TNF protein; in vivo; insight; interest; lupus prone mice; macrophage; male; men; mesangial cell; mortality; mutant; new therapeutic target; novel; novel strategies; promoter; protective effect; public health relevance; receptor; receptor expression; response; sle1/sle3 gene