Disease-Modifying Effects of Filgastrim in a Mouse Model of AD

非加司亭对 AD 小鼠模型的疾病缓解作用

• 批准号: 7907865
• 负责人: JUAN R SANCHEZ-RAMOS
• 金额: --
• 依托单位: JAMES A. HALEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907865
• 关键词: APP-PS1; Accounting; Aftercare; Age; Alternative Splicing; Alzheimer' s Disease; Alzheimer' s disease model; Amyloid; Amyloid beta-Protein; Amyloid deposition; Apoptosis; Area; Behavioral; Birth; Blood Cells; Bone Marrow; Bone Marrow Cells; Bone Marrow Stem Cell; Brain; Brain Diseases; Bromodeoxyuridine; CSF3 gene; Cells; Cessation of life; Clinical Trials; Cognition Disorders; Cognitive; Dementia; Dendritic Spines; Deposition; Development; Disease; Electrophysiology (science); Event; Generations; Golgi Apparatus; Granulocyte Colony-Stimulating Factor; Green Fluorescent Proteins; Healthcare Systems; Hematology; Hematopoietic Cell Growth Factors; Hematopoietic stem cells; Hippocampus (Brain); Immunohistochemistry; Impaired cognition; In Vitro; Infiltration; Laboratories; Learning; Literature; Long-Term Depression; Long-Term Potentiation; Measures; Mediating; Methods; Microglia; Mission; Molecular; Molecular Biology Techniques; Morphology; Mus; Neuraxis; Neurodegenerative Disorders; Neurons; Neutropenia; Outcome; Pathogenesis; Patients; Performance; Pharmaceutical Preparations; Phosphorylation; Physiological; Population; Prevalence; Production; Protein Isoforms; Protein Kinase C; RNA Splicing; Recovery; Reporting; Research Design; Research Project Grants; Schedule; Signal Pathway; Signal Transduction; Slice; Staining method; Stains; Stem cells; Structure; Synapses; Synaptophysin; Techniques; Testing; Therapeutic; Therapeutic Agents; Transgenic Mice; Transgenic Organisms; Translations; Variant; Veterans; Work; age related; brain repair; clinically relevant; cytokine; design; entorhinal cortex; granulocyte; immunoreactivity; improved; in vivo; light treatment; macrophage; mimetics; mouse model; nerve stem cell; neurofilament; neurogenesis; new therapeutic target; novel; oncology; pre-clinical research; progenitor; programs; public health relevance; receptor; relating to nervous system; restoration; socioeconomics; stem; synaptic function; tau Proteins; tau phosphorylation; trafficking