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Disease-Modifying Effects of Filgastrim in a Mouse Model of AD

Disease-Modifying Effects of Filgastrim in a Mouse Model of AD
非加司亭对 AD 小鼠模型的疾病缓解作用
批准号：
7907865
负责人：
JUAN R SANCHEZ-RAMOS
金额：
$0.0万
依托单位：
JAMES A. HALEY VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2014-03-31
来源：
https://reporter.nih.gov/project-details/7907865
关键词：
APP-PS1AccountingAftercareAgeAlternative SplicingAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAmyloidAmyloid beta-ProteinAmyloid depositionApoptosisAreaBehavioralBirthBlood CellsBone MarrowBone Marrow CellsBone Marrow Stem CellBrainBrain DiseasesBromodeoxyuridineCSF3 geneCellsCessation of lifeClinical TrialsCognition DisordersCognitiveDementiaDendritic SpinesDepositionDevelopmentDiseaseElectrophysiology (science)EventGenerationsGolgi ApparatusGranulocyte Colony-Stimulating FactorGreen Fluorescent ProteinsHealthcare SystemsHematologyHematopoietic Cell Growth FactorsHematopoietic stem cellsHippocampus (Brain)ImmunohistochemistryImpaired cognitionIn VitroInfiltrationLaboratoriesLearningLiteratureLong-Term DepressionLong-Term PotentiationMeasuresMediatingMethodsMicrogliaMissionMolecularMolecular Biology TechniquesMorphologyMusNeuraxisNeurodegenerative DisordersNeuronsNeutropeniaOutcomePathogenesisPatientsPerformancePharmaceutical PreparationsPhosphorylationPhysiologicalPopulationPrevalenceProductionProtein IsoformsProtein Kinase CRNA SplicingRecoveryReportingResearch DesignResearch Project GrantsScheduleSignal PathwaySignal TransductionSliceStaining methodStainsStem cellsStructureSynapsesSynaptophysinTechniquesTestingTherapeuticTherapeutic AgentsTransgenic MiceTransgenic OrganismsTranslationsVariantVeteransWorkage relatedbrain repairclinically relevantcytokinedesignentorhinal cortexgranulocyteimmunoreactivityimprovedin vivolight treatmentmacrophagemimeticsmouse modelnerve stem cellneurofilamentneurogenesisnew therapeutic targetnoveloncologypre-clinical researchprogenitorprogramspublic health relevancereceptorrelating to nervous systemrestorationsocioeconomicsstemsynaptic functiontau Proteinstau phosphorylationtrafficking

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