CELLULAR TOXICOLOGY OF THE DOPAMINE NEURON
多巴胺神经元的细胞毒理学
基本信息
- 批准号:3083870
- 负责人:
- 金额:$ 6.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-04-01 至 1991-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The candidate is a pharmacologist and neurologist with research
experience in behavioral pharmacology and clinical research
training in movement disorders. His-special interests include
extrapyramidal syndromes and neurotoxic consequences of drug use.
Research proposed here concerns MPTP (l-methyl-4-phenyl-1,2,3,6-
tetrahydropyridine), a meperidine analogue which produces changes
that mimic the lesion of Parkinson's disease in primates and other
species. Despite advances in understanding some aspects of the
mechanism by which the drug causes neuronal degeneration, many
basic questions remain unanswered due primarily to the complexity
of in vivo research on the central nervous system. One approach
to this problem is to elucidate the mechanism of action of MPTP in
vitro by studying the effects of the toxin on cell cultures of
dopaminergic neurons and upon striatal (or midbrain) slices.
Specific aims of this research are: 1) to characterize the
selectivity and irreversibility of MPTP and MPP+ toxicity towards
dopamine neurons in culture, 2) to test the hypothesis that MPP+
acts primarily on neuronal fibers, with subsequent retrograde
degeneration of the neuron, 3) to test the hypothesis that
oxyradicals mediate MPP+ induced destruction of dopamine neurons,
4) to test the hypothesis that mitochondrial electron transport
is inhibited by MPP+ in rat (or mouse) striatal and midbrain
slices as measured with scanning spectrophotometer, and 5) to test
the hypothesis that target tissue (striatal cells) influences MPP+
neurotoxicity and facilitates recovery of dopamine neurons from
sub-lethal damage. The University of Miami Dept of Neurology
provides outstanding resources for development of a clinical
investigator: fully equipped laboratories, basic research staff,
out-patient clinics, hospital neurology ward, students and
housestaff.
候选人是一位药理学家和神经学家
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JUAN R SANCHEZ-RAMOS其他文献
JUAN R SANCHEZ-RAMOS的其他文献
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{{ truncateString('JUAN R SANCHEZ-RAMOS', 18)}}的其他基金
Nanocarriers Designed to Deliver Nucleic Acids to Brain
旨在将核酸输送到大脑的纳米载体
- 批准号:
9770565 - 财政年份:2015
- 资助金额:
$ 6.61万 - 项目类别:
Nanocarriers Designed to Deliver Nucleic Acids to Brain
旨在将核酸输送到大脑的纳米载体
- 批准号:
9147011 - 财政年份:2015
- 资助金额:
$ 6.61万 - 项目类别:
Nanocarriers Designed to Deliver Nucleic Acids to Brain
旨在将核酸输送到大脑的纳米载体
- 批准号:
9338335 - 财政年份:2015
- 资助金额:
$ 6.61万 - 项目类别:
Disease-Modifying Effects of Filgastrim in a Mouse Model of AD
非加司亭对 AD 小鼠模型的疾病缓解作用
- 批准号:
7797233 - 财政年份:2009
- 资助金额:
$ 6.61万 - 项目类别:
Disease-Modifying Effects of Filgastrim in a Mouse Model of AD
非加司亭对 AD 小鼠模型的疾病缓解作用
- 批准号:
7907865 - 财政年份:2009
- 资助金额:
$ 6.61万 - 项目类别:
Disease-Modifying Effects of Filgastrim in a Mouse Model of AD
非加司亭对 AD 小鼠模型的疾病缓解作用
- 批准号:
8397542 - 财政年份:2009
- 资助金额:
$ 6.61万 - 项目类别:
Disease-Modifying Effects of Filgastrim in a Mouse Model of AD
非加司亭对 AD 小鼠模型的疾病缓解作用
- 批准号:
8195930 - 财政年份:2009
- 资助金额:
$ 6.61万 - 项目类别:














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