Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD

PTSD 动物模型的神经内分泌机制和治疗方法

• 批准号: 7910594
• 负责人: David Mark Diamond
• 金额: --
• 依托单位: JAMES A. HALEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7910594
• 关键词: AMPA Receptors; Acetylation; Acute; Address; Adrenergic Antagonists; Adverse effects; Affect; Amygdaloid structure; Animal Model; Anticonvulsants; Antidepressive Agents; Anxiety; Anxiety Disorders; Area; Attenuated; BDNF gene; Behavior; Behavioral; Biological; Biological Assay; Brain; CRF receptor type 1; Calcium; Calmodulin; Cardiovascular system; Chromatin; Cognitive; Cognitive deficits; Complex; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP-Responsive DNA-Binding Protein; DNA Methylation; Development; Disease model; Effectiveness; Emotional; Endocrine system; Epigenetic Process; Epinephrine; Etiology; Event; Exhibits; Feedback; Felis catus; Fright; Functional disorder; Funding; Glucocorticoid Receptor; Glucocorticoids; Glutamates; Goals; Health; Heart Diseases; Hippocampus (Brain); Histone H3; Hormonal; Hospitalization; Human; Hydrocortisone; Hypothalamic structure; Immune system; Incidence; Individual; Laboratories; Learning; Link; Measures; Medical Research; Memory; Mental Depression; Mental Health; Mental disorders; Metabolic; Methylation; Mineralocorticoid Receptor; Mineralocorticoids; Modeling; Molecular; Mood Disorders; N-Methyl-D-Aspartate Receptors; Neurobiology; Neurosecretory Systems; Non-Insulin-Dependent Diabetes Mellitus; Paper; Pharmacological Treatment; Pharmacotherapy; Phenotype; Phosphorylation; Phosphotransferases; Physiological; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Psyche structure; Psychosocial Stress; Rattus; Receptor Activation; Reducing Agents; Regimen; Regulation; Research; Retrieval; Signal Transduction; Signaling Molecule; Stress; Symptoms; System; Testing; Therapeutic; Therapeutic Studies; Tissues; Trauma; Veterans; Work; Yohimbine; base; brain behavior; cardiovascular disorder risk; channel blockers; clinical efficacy; combat; conditioned fear; corticosterone receptor; effective therapy; emotional trauma; experience; high risk; hypothalamic-pituitary-adrenal axis; improved; insight; lamotrigine; mRNA Expression; meetings; memory process; memory retrieval; physical conditioning; population health; programs; public health relevance; receptor; research study; response; social; stressor; therapeutic development; tianeptine