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Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference

Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
通过宿主细胞 RNA 干扰抑制粘膜 HIV-1 传播
批准号:
7910642
负责人:
ALEXANDRA L HOWELL
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-10-01 至 2013-09-30
关键词:
AdultAffectAnimal ModelAntibodiesAntigen PresentationAntigen-Presenting CellsAntigensAntiretroviral resistanceAreaB-LymphocytesBindingBiological ModelsBlood CellsC Type Lectin ReceptorsC-Type LectinsCCR5 geneCD4 AntigensCD4 Positive T LymphocytesCXCR4 ReceptorsCXCR4 geneCell CountCellsCenters for Disease Control and Prevention (U.S.)Chemokine (C-C Motif) Receptor 5ChildCoitusControl GroupsDendritic CellsDepositionDevelopmentDiseaseDoseEndocytosisEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryFoundationsGastrointestinal tract structureGenetic TranscriptionGenital systemGoalsHIVHIV ReceptorsHIV-1HealthHealthcareHealthcare SystemsHumanHuman CharacteristicsImmuneImmune responseImmune systemImmunologic Deficiency SyndromesIncidenceIndividualInfectionInvadedInvestigationKineticsLeadLectinLeukocytesLifeLymphocyteLymphoid CellMeasurementMeasuresMediatingMilitary PersonnelModelingMonitorMucosal Immune ResponsesMucous MembraneMusMyeloid CellsNucleic AcidsPathogenesisPathologyPeptidesPeripheralPersonsPharmaceutical PreparationsPlasmaPlayPopulationProcessProteinsRNARNA InterferenceReagentReportingRetroviridaeReverse TranscriptionRoleRouteScientistSiteStem cellsSurfaceSynapsesT-Cell ReceptorT-LymphocyteTechnologyTestingTetanus ToxoidTherapeuticTimeTissuesToxic effectTransfectionVaccinesVeteransViralViral Load resultViral ProteinsVirusbasechemokine receptorcytokinedesignfunctional disabilitygastrointestinalhuman stem cellsimmunodeficient mouse modelin vivointercellular cell adhesion moleculelymph nodesmacrophagemicrobicidemucosal sitenanoparticlenovel strategiesnovel therapeutic interventionparticlepathogenpreventreceptorreceptor bindingreceptor expressionreconstitutionrectalreproductiveresponsetraffickingtransmission processuptake

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Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
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