Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury

缺血再灌注损伤中食糜酶介导的 MMP 激活

• 批准号: 7916753
• 负责人: Louis J. Dell'Italia
• 金额: --
• 依托单位: BIRMINGHAM VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916753
• 关键词: Acute; Acute myocardial infarction; Address; Adult; Angiotensins; Animal Model; Anterior; Area; Arrhythmia; Attenuated; Balloon Occlusion; Biopsy Specimen; Blood flow; Canis familiaris; Cardiac Myocytes; Cardiac Surgery procedures; Cardiopulmonary Bypass; Caring; Catheters; Cell Nucleus; Cell Surface Proteins; Cell Survival; Cells; Cessation of life; Chest; Chest Pain; Chronic; Chymase; Cicatrix; Cleaved cell; Clinical; Community Hospitals; Coronary Occlusions; Coupled; DNA Damage; DNA Repair Enzymes; Data; Edema; Edetic Acid; Evaluation; Event; Fibronectins; Focal Adhesion Kinase 1; Functional disorder; Gadolinium; Gel; Gelatinase A; Gelatinase B; Health; Heart Arrest; Hospitals; Hour; Immunohistochemistry; In Situ; In Vitro; Incidence; Infarction; Inflammatory; Infusion procedures; Injury; Intravenous; Intravenous infusion procedures; Ischemia; Isoelectric Focusing; Laminin; Left; Length; MAPK8 gene; Magnetic Resonance Imaging; Mass Spectrum Analysis; Matrix Metalloproteinase Inhibitor; Matrix Metalloproteinases; Mediating; Mission; Modeling; Molecular; Molecular Weight; Morbidity - disease rate; Muscle Cells; Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myofibrils; Myosin ATPase; Nuclear; Nuclear Matrix-Associated Proteins; Nuclear Protein; Oral; Organ; Organ Transplantation; Patients; Perfusion; Pharmaceutical Preparations; Phase; Play; Poly(ADP-ribose) Polymerases; Protein Dephosphorylation; Proteins; Proteomics; Regulation; Reperfusion Injury; Reperfusion Therapy; Reporting; Risk; Role; Sepharose; Signal Pathway; Signal Transduction; Smooth Muscle Myocytes; Spottings; Stress; Surface; Survivors; Testing; Thrombolytic Therapy; Time; Time Study; Tissues; Veterans; Weight; abstracting; acute coronary syndrome; base; clinically relevant; coronary angioplasty; electric impedance; enzyme activity; gadolinium oxide; improved; in vivo; inhibitor/antagonist; interstitial; mast cell; mitogen-activated protein kinase p38; mortality; novel; outcome forecast; patient population; percutaneous coronary intervention; prevent; public health relevance; response; restoration