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Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury

Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
缺血再灌注损伤中食糜酶介导的 MMP 激活
批准号：
7916753
负责人：
Louis J. Dell'Italia
金额：
$0.0万
依托单位：
BIRMINGHAM VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2013-09-30
来源：
https://reporter.nih.gov/project-details/7916753
关键词：
AcuteAcute myocardial infarctionAddressAdultAngiotensinsAnimal ModelAnteriorAreaArrhythmiaAttenuatedBalloon OcclusionBiopsy SpecimenBlood flowCanis familiarisCardiac MyocytesCardiac Surgery proceduresCardiopulmonary BypassCaringCathetersCell NucleusCell Surface ProteinsCell SurvivalCellsCessation of lifeChestChest PainChronicChymaseCicatrixCleaved cellClinicalCommunity HospitalsCoronary OcclusionsCoupledDNA DamageDNA Repair EnzymesDataEdemaEdetic AcidEvaluationEventFibronectinsFocal Adhesion Kinase 1Functional disorderGadoliniumGelGelatinase AGelatinase BHealthHeart ArrestHospitalsHourImmunohistochemistryIn SituIn VitroIncidenceInfarctionInflammatoryInfusion proceduresInjuryIntravenousIntravenous infusion proceduresIschemiaIsoelectric FocusingLamininLeftLengthMAPK8 geneMagnetic Resonance ImagingMass Spectrum AnalysisMatrix Metalloproteinase InhibitorMatrix MetalloproteinasesMediatingMissionModelingMolecularMolecular WeightMorbidity - disease rateMuscle CellsMyocardialMyocardial InfarctionMyocardial IschemiaMyocardial ReperfusionMyofibrilsMyosin ATPaseNuclearNuclear Matrix-Associated ProteinsNuclear ProteinOralOrganOrgan TransplantationPatientsPerfusionPharmaceutical PreparationsPhasePlayPoly(ADP-ribose) PolymerasesProtein DephosphorylationProteinsProteomicsRegulationReperfusion InjuryReperfusion TherapyReportingRiskRoleSepharoseSignal PathwaySignal TransductionSmooth Muscle MyocytesSpottingsStressSurfaceSurvivorsTestingThrombolytic TherapyTimeTime StudyTissuesVeteransWeightabstractingacute coronary syndromebaseclinically relevantcoronary angioplastyelectric impedanceenzyme activitygadolinium oxideimprovedin vivoinhibitor/antagonistinterstitialmast cellmitogen-activated protein kinase p38mortalitynoveloutcome forecastpatient populationpercutaneous coronary interventionpreventpublic health relevanceresponserestoration

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