Impact of genetic variation TLR/CD14 pathways and smoking in RA

遗传变异 TLR/CD14 通路和吸烟对 RA 的影响

• 批准号: 7787500
• 负责人: TED RICHARD MIKULS
• 金额: --
• 依托单位: OMAHA VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7787500
• 关键词: Affect; African American; Aging; Alabama; Alleles; Ally; American; Animal Model; Antigens; Arthritis; Attenuated; Autoantibodies; Autoimmune Process; Autoimmunity; CD14 gene; Candidate Disease Gene; Caucasians; Caucasoid Race; Cells; Collaborations; Data; Detection; Disease; Disease susceptibility; Endotoxins; Epitopes; Evaluation; Exposure to; Fibrinogen; Gene-Modified; General Population; Genes; Genetic; Genetic Polymorphism; Genetic Variation; HLA-DRB1; Health; Health Care Costs; Healthcare; Heat shock proteins; High Prevalence; Inflammatory; Ligands; Link; Lung; Lung nodule; Measures; Mediating; Mediator of activation protein; Minority; Morbidity - disease rate; Natural Immunity; Outcome; PTPN22 gene; Pathology; Pathway interactions; Pattern recognition receptor; Peptide antibodies; Play; Population; Prevalence; Production; Protein Tyrosine Phosphatase; Receptor Gene; Receptor Signaling; Research; Research Personnel; Rheumatoid Arthritis; Rheumatoid Factor; Rheumatoid Nodule; Risk; Risk Factors; Role; Serum; Severities; Severity of illness; Single Nucleotide Polymorphism; Smoker; Smoking; Synovial Membrane; TLR9 gene; Techniques; Testing; Toll-Like Receptor 1; Toll-Like Receptor 2; Toll-Like Receptor Pathway; Toll-like receptor 6; Toll-like receptors; Universities; Variant; Veterans; Woman; adaptive immunity; arthritis registry; cigarette smoking; cigarette smoking; cohort; cyclic citrullinated peptide; cytokine; disability; disease phenotype; genetic risk factor; human TLR7 protein; insight; joint destruction; male; men; mortality; novel; public health relevance; receptor expression; smoking prevalence; toll-like receptor 4