IGF::OT::IGF "EARLY MARKERS OF ALZHEIMER DISEASE: PET TAU IMAGING IN THE BALTIMORE LONGITUDINAL STUDY OF AGING (BLSA) PARTICIPANTS PROJECT" FOR THE NATIONAL INSTITUTE ON AGING (NIA). THE CONTRACTOR'S

重点收集和分析巴尔的摩老龄化纵向研究（BLSA）参与者的神经影像学数据。该项目将继续为研究人员和临床医生提供关于大脑结构和功能的年龄变化，其与认知变化的关联以及调节这些关联的因素的重要信息，包括认知衰退和阿尔茨海默病的风险因素。最近的一些研究表明，特定颞叶区域的结构和功能纵向变化预测认知障碍和阿尔茨海默病，但很少有研究提供整个大脑区域的纵向变化数据，以及灰质和白色物质。利用新的成像方法，我们将继续研究认知障碍和痴呆的神经生物学基础。除了继续进行脑老化的体积研究外，在下一阶段的研究计划中应强调血管变化和淀粉样蛋白沉积的体内测量。最近的证据表明，血管变化和阿尔茨海默病病理学对痴呆症的发展可能具有协同作用。由于目前年龄在55岁及以上的样本中约有一半入组BLSA尸检项目，因此将根据神经病理学结果验证体内成像变化。除了继续对老年人进行研究外，BLSA中的年轻人将被招募进行MR成像研究，以提供有关整个成年期大脑结构变化的信息。通过使用BLSA参与者现有的生理和心理数据，该项目将为我们理解神经解剖学，神经生理学和认知老化速度的个体差异预测因素提供独特的见解。这些神经影像学数据也将提供重要的规范性数据，包括社区居民个体大脑异常的频率和程度，从中评估病理性

To focus on the acquisition and analysis of neuroimaging data on Baltimore Longitudinal Study of Aging (BLSA) participants. This project will continue to provide important information for researchers and clinicians on age changes in brain structure and function, their associations with cognitive change, and factors that modulate these associations, including risk factors for cognitive decline and Alzheimer's disease. A number of recent studies indicate that structural and functional longitudinal changes in specific temporal lobe regions predict cognitive impairment and Alzheimer's disease, but there are few studies that provide data on longitudinal changes in regions throughout the brain and for both gray and white matter. Using new imaging methods, we will continue to investigate the neurobiological basis of cognitive impairment and dementia. In addition to continued volumetric studies ofbrain aging, in vivo measurement ofvascular changes and amyloid deposition shall be emphasized in the next phase of this research program. Recent evidence indicates possible synergistic effects of vascular changes and Alzheimer's pathology on the development of dementia. As approximately half of the current sample aged 55 and older is enrolled in the BLSA autopsy program, in vivo imaging changes will be validated against neuropathological findings. In addition to the continued investigation of older adults, younger individuals in the BLSA will be recruited for MR imaging studies to provide information on structural brain changes throughout the adult lifespan. Through the use of the existing physical and psychological data for BLSA participants, this project will provide unique insights into our understanding ofpredictors of individual differences in the rate ofneuroanatomic, neurophysiologic and cognitive aging.This neuroimaging data will also provide important normative data, including the frequency and extent ofbrain abnormalities in community-dwelling individuals, from which to evaluate pathological