IGF::OT::IGF "EARLY MARKERS OF ALZHEIMER DISEASE: PET TAU IMAGING IN THE BALTIMORE LONGITUDINAL STUDY OF AGING (BLSA) PARTICIPANTS PROJECT" FOR THE NATIONAL INSTITUTE ON AGING (NIA). THE CONTRACTOR'S

重点研究巴尔的摩老龄纵向研究(BLSA)参与者的神经影像数据的获取和分析。该项目将继续为研究人员和临床医生提供关于大脑结构和功能的年龄变化、它们与认知变化的关联以及调节这些关联的因素，包括认知衰退和阿尔茨海默病的风险因素的重要信息。最近的一些研究表明，特定颞叶区域的结构和功能纵向变化可以预测认知障碍和阿尔茨海默病，但很少有研究提供整个大脑区域以及灰质和白质的纵向变化数据。利用新的成像方法，我们将继续研究认知障碍和痴呆的神经生物学基础。除了继续进行脑老化的体积研究外，在下一阶段的研究计划中还应强调血管变化和淀粉样蛋白沉积的活体测量。最近的证据表明，血管变化和阿尔茨海默氏病的病理可能在痴呆的发展中起协同作用。由于目前年龄在55岁及以上的样本中约有一半参加了BLSA尸检计划，体内成像变化将与神经病理结果进行验证。除了继续对老年人进行调查外，BLSA中的年轻人将被招募进行磁共振成像研究，以提供有关成年人一生中大脑结构变化的信息。通过使用BLSA参与者现有的生理和心理数据，该项目将为我们理解神经解剖、神经生理学和认知衰老比率的个体差异的预测因素提供独特的见解。这些神经成像数据也将提供重要的规范数据，包括居住在社区的个人大脑异常的频率和程度，用于评估病理

To focus on the acquisition and analysis of neuroimaging data on Baltimore Longitudinal Study of Aging (BLSA) participants. This project will continue to provide important information for researchers and clinicians on age changes in brain structure and function, their associations with cognitive change, and factors that modulate these associations, including risk factors for cognitive decline and Alzheimer's disease. A number of recent studies indicate that structural and functional longitudinal changes in specific temporal lobe regions predict cognitive impairment and Alzheimer's disease, but there are few studies that provide data on longitudinal changes in regions throughout the brain and for both gray and white matter. Using new imaging methods, we will continue to investigate the neurobiological basis of cognitive impairment and dementia. In addition to continued volumetric studies ofbrain aging, in vivo measurement ofvascular changes and amyloid deposition shall be emphasized in the next phase of this research program. Recent evidence indicates possible synergistic effects of vascular changes and Alzheimer's pathology on the development of dementia. As approximately half of the current sample aged 55 and older is enrolled in the BLSA autopsy program, in vivo imaging changes will be validated against neuropathological findings. In addition to the continued investigation of older adults, younger individuals in the BLSA will be recruited for MR imaging studies to provide information on structural brain changes throughout the adult lifespan. Through the use of the existing physical and psychological data for BLSA participants, this project will provide unique insights into our understanding ofpredictors of individual differences in the rate ofneuroanatomic, neurophysiologic and cognitive aging.This neuroimaging data will also provide important normative data, including the frequency and extent ofbrain abnormalities in community-dwelling individuals, from which to evaluate pathological