IGF::OT::IGF "EARLY MARKERS OF ALZHEIMER DISEASE: PET TAU IMAGING IN THE BALTIMORE LONGITUDINAL STUDY OF AGING (BLSA) PARTICIPANTS PROJECT" FOR THE NATIONAL INSTITUTE ON AGING (NIA). THE CONTRACTOR'S

目的：探讨巴尔的摩老龄化纵向研究（BLSA）参与者神经影像学数据的采集与分析。该项目将继续为研究人员和临床医生提供重要信息，了解大脑结构和功能的年龄变化、它们与认知变化的关系，以及调节这些关系的因素，包括认知能力下降和阿尔茨海默病的风险因素。最近的一些研究表明，特定颞叶区域的结构和功能纵向变化可以预测认知障碍和阿尔茨海默病，但很少有研究提供整个大脑区域以及灰质和白质纵向变化的数据。利用新的成像方法，我们将继续研究认知障碍和痴呆的神经生物学基础。除了继续进行脑老化的体积研究外，血管变化和淀粉样蛋白沉积的体内测量将在该研究计划的下一阶段得到强调。最近的证据表明，血管变化和阿尔茨海默病病理在痴呆症的发展中可能具有协同作用。目前大约有一半年龄在55岁及以上的患者参加了BLSA尸检项目，体内成像变化将与神经病理结果相对照进行验证。除了对老年人的持续调查外，BLSA还将招募年轻人进行磁共振成像研究，以提供整个成人寿命期间大脑结构变化的信息。通过使用BLSA参与者现有的生理和心理数据，该项目将为我们对神经解剖、神经生理和认知衰老率的个体差异预测因素的理解提供独特的见解。这些神经影像学数据也将提供重要的规范性数据，包括社区居民大脑异常的频率和程度，从中评估病理

To focus on the acquisition and analysis of neuroimaging data on Baltimore Longitudinal Study of Aging (BLSA) participants. This project will continue to provide important information for researchers and clinicians on age changes in brain structure and function, their associations with cognitive change, and factors that modulate these associations, including risk factors for cognitive decline and Alzheimer's disease. A number of recent studies indicate that structural and functional longitudinal changes in specific temporal lobe regions predict cognitive impairment and Alzheimer's disease, but there are few studies that provide data on longitudinal changes in regions throughout the brain and for both gray and white matter. Using new imaging methods, we will continue to investigate the neurobiological basis of cognitive impairment and dementia. In addition to continued volumetric studies ofbrain aging, in vivo measurement ofvascular changes and amyloid deposition shall be emphasized in the next phase of this research program. Recent evidence indicates possible synergistic effects of vascular changes and Alzheimer's pathology on the development of dementia. As approximately half of the current sample aged 55 and older is enrolled in the BLSA autopsy program, in vivo imaging changes will be validated against neuropathological findings. In addition to the continued investigation of older adults, younger individuals in the BLSA will be recruited for MR imaging studies to provide information on structural brain changes throughout the adult lifespan. Through the use of the existing physical and psychological data for BLSA participants, this project will provide unique insights into our understanding ofpredictors of individual differences in the rate ofneuroanatomic, neurophysiologic and cognitive aging.This neuroimaging data will also provide important normative data, including the frequency and extent ofbrain abnormalities in community-dwelling individuals, from which to evaluate pathological