Motivated Memory as Therapeutic Target

动机记忆作为治疗目标

• 批准号: 8644932
• 负责人: Rachel Alison Adcock
• 金额: $ 46.33万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-13 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8644932
• 关键词: Access to Information; Affect; Behavior; Behavioral; Biological; Brain; Chronic; Clinical; Cognitive; Cognitive Therapy; Cues; Development; Dopamine; Episodic memory; Equilibrium; Etiology; Event; Feedback; Foundations; Frequencies; Functional Magnetic Resonance Imaging; Future; Goals; Hippocampus (Brain); Imagery; Intervention; Learning; Life; Long-Term Effects; Measures; Medial; Mediating; Memory; Methods; Midbrain structure; Neurotransmitters; Participant; Patients; Protocols documentation; Proxy; Psychiatry; Psychopharmacology; Psychotherapy; Readiness; Regulation; Rewards; Role; Series; Signal Transduction; Stimulus; Symptoms; System; Techniques; Temporal Lobe; Testing; Therapeutic; Time; Validation; Work; abstracting; base; design; dopamine system; experience; follow-up; insight; memory encoding; mesolimbic system; non-drug; psychologic; relating to nervous system; research study; response; success; therapeutic target

DESCRIPTION (provided by applicant): Declarative or episodic memory systems based in the hippocampus and medial temporal lobes are specialized for rapid reorientation to new contexts, supporting appropriately rapid shifts in behavior. Surprisingly, the potential for leveraging these mechanisms in cognitive therapy remains untapped. We have demonstrated that increased fMRI activation of declarative memory systems together with dopaminergic midbrain during reward anticipation correlates with memory encoding for upcoming experience. Our findings suggest a method and mechanism for using "behavioral neurostimulation" of dopaminergic systems to prime the hippocampus for learning. This approach contrasts with conventional paradigms in psychopharmacology where the goal is chronic equilibrium of neuromodulatory systems. Here, the adjustment is explicitly targeted to the period of learning. We propose three series of experiments designed to 1) to test the existence of a causal relationship between mesolimbic activation per se and memory encoding success using real-time fMRI; 2) to demonstrate the suitability of this phenomenon to clinical interventions; and 3) determine long-term effects on behavior from the impact of a single salient episode in a therapeutic session. We expect these studies to provide a foundation for using cognitive and behavioral regulation of dopamine systems to prepare the brain for adaptive learning.

描述(由申请人提供)：基于海马体和内侧颞叶的陈述性或情景记忆系统专门用于快速重新定位到新的背景，支持适当的快速行为转变。令人惊讶的是，在认知治疗中利用这些机制的潜力仍未开发。我们已经证明，在奖励预期过程中，陈述性记忆系统和多巴胺能中脑的fMRI激活增加与即将到来的经验的记忆编码有关。我们的发现提出了一种方法和机制，可以使用多巴胺能系统的“行为神经刺激”来为学习准备海马体。这种方法与精神药理学的传统范式形成对比，后者的目标是神经调节系统的慢性平衡。在这里，调整明确针对学习阶段。我们提出了三个系列的实验，旨在1)使用实时功能磁共振成像来测试中边缘激活本身与记忆编码成功之间是否存在因果关系；2)证明这一现象对临床干预的适用性；3)根据治疗过程中单个显著事件的影响来确定对行为的长期影响。我们期待这些研究为利用多巴胺系统的认知和行为调节来为大脑的适应性学习做好准备提供基础。