Aerobic Exercise to Improve Outcomes of Treatment for Methamphetamine Dependence

项目总结/摘要 项目描述：这项为期五年的研究将收集有氧运动对 在Cri-Help寻求治疗的150人中治疗甲基苯丙胺依赖 洛杉矶的住院戒毒项目签署知情同意书并满足所有入选/排除要求后 根据要求，受试者将入组研究，并在研究期间接受基线评估。 像往常一样治疗大约两周。随机分组后，参与者将参加 条件（n=75）或对照（健康教育; n=75）条件下进行为期8周的干预。 参加任何一种条件活动（每周三次）的奖励固定为每次10美元。的150 共有30名自愿参与者将参与脑成像子研究。的目的 影像学子研究是为了确定与运动的假设效应相关的可能的脑机制 治疗结果的影响。这项研究的主要目标是严格和全面地确定是否 将有氧运动纳入住院计划可以改善治疗效果， 在出院后的前12周和26周随访期间使用甲基苯丙胺，以及 与对照组相比，描述运动对健康、精神症状和认知的影响 （教育）组干预前/后。研究的目的是： 目标1.描述有氧运动干预（“运动”）与健康教育相比的效果 （“教育”）方面的药物使用出院后的住院戒毒治疗的人口MA- 依赖的个体。 目标二。为了表征运动对MA渴望和包括焦虑在内的负面情感状态的影响， 抑郁症，快感缺乏和应激反应的参与者在住宅治疗的MA依赖。 目标3。描述运动对神经认知功能的影响。 目标4。描述运动条件下参与者之间健康相关结局的变化 与教育条件下相比。 目标5。检查戒断MA依赖受试者中多巴胺D2/D3受体可用性的变化 分配到锻炼组的参与者与教育（对照）组的参与者子样本相比（n = 每组15个）。 目标6。检查成瘾相关行为的差异（根据ASI类型测量）， 干预条件 迫切需要对治疗甲基苯丙胺使用的战略进行系统评价 紊乱因此，本项目响应NIDA的要求（RFA-DA-09-013），开发和评估有效的 以运动为基础的成瘾干预

Project Summary/Abstract Description of the Project: This five-year study will assemble data on the efficacy of aerobic exercise for the treatment of methamphetamine dependence in a population of 150 individuals seeking treatment at Cri-Help residential drug treatment program in Los Angles. After signing consent and satisfying all inclusion/exclusion requirements, participants will be enrolled into the study and undergo baseline assessments during approximately two weeks of treatment as usual. After randomization, participants will enter the Exercise condition (n=75) or the control (Health Education; n=75) condition for an 8-week intervention duration. Incentives for participation in either condition activity (thrice weekly) are fixed at $10 per session. Of the 150 total participants, 30 voluntary participants will be part of a brain imaging substudy. The objective of the imaging substudy is to determine possible brain mechanisms associated with hypothesized effects of exercise on treatment outcomes. The primary goal of the study is to rigorously and comprehensively determine whether inclusion of a aerobic exercise within a residential program improves treatment outcomes in terms of reduced methamphetamine use during the first 12 weeks post discharge and 26 week follow up, as well as to characterize effects of exercise on health, psychiatric symptoms and cognition compared to the control (education) group pre/post intervention. Aims of the study are: Aim 1. To characterize effects of an aerobic exercise intervention ("Exercise") compared to health education ("Education") in terms of drug use after discharge from residential drug treatment in a population of MA- dependent individuals. Aim 2. To characterize effects of Exercise on MA craving and negative affective states including anxiety, depression, anhedonia, and stress reactivity among participants in residential treatment for MA dependence. Aim 3. To characterize effects of Exercise on neurocognitive functioning. Aim 4. To characterize variations in health-related outcomes among participants in the Exercise condition compared with those in the Education condition. Aim 5. To examine changes in dopamine D2/D3 receptor availability in abstinent MA-dependent participants assigned to an Exercise group compared to a subsample of participants in an Education (control) group (n = 15 per group). Aim 6. To examine differences in addiction-related behaviors (per ASI-type measures) according to intervention condition. There is a critical need for systematic evaluation of strategies for treating methamphetamine use disorders. Thus, this project responds to NIDA request (RFA-DA-09-013) to develop and evaluate an effective exercise-based intervention for addiction.