Aerobic Exercise to Improve Outcomes of Treatment for Methamphetamine Dependence

项目摘要/摘要 项目简介：这项为期五年的研究将收集有氧运动对 在Cri-Help寻求治疗的150人中对甲基苯丙胺依赖的治疗 洛杉矶的住宅戒毒计划。在签署同意书并满足所有包含/排除 要求，参与者将被纳入这项研究，并在 像往常一样接受大约两周的治疗。随机化后，参与者将进入练习 条件(n=75)或对照组(健康教育；n=75)，为期8周的干预。 参加任一条件活动(每周三次)的奖励固定为每期10美元。在150个人中 总共有30名自愿参与者将参与一项脑成像分研究。该计划的目标是 成像亚研究旨在确定与运动的假想效果相关的可能的大脑机制 关于治疗结果的。这项研究的主要目标是严格和全面地确定 在住宿计划中包括有氧运动可以改善治疗结果，减少 在出院后头12周和26周随访期间使用甲基苯丙胺，以及 描述与对照组相比，锻炼对健康、精神症状和认知的影响 (教育)团体干预前/后。这项研究的目的是： 目的1.比较有氧运动干预(“运动”)与健康教育的效果 (“教育”)在马萨诸塞州居民戒毒出院后的药物使用方面-- 独立的个体。 目的2.研究运动对MA渴求和包括焦虑在内的消极情绪状态的影响。 住院治疗MA依赖患者中的抑郁、快感缺乏和应激反应。 目的3.研究运动对神经认知功能的影响。 目的4.描述运动条件下参与者的健康相关结果的差异 与处于教育条件下的人相比。 目的5.检测戒断性MA依赖参与者多巴胺D2/D3受体可用性的变化 分配到锻炼组与教育(对照)组参与者的子样本进行比较(n= 每组15人)。 目的6.检验成瘾相关行为的差异(根据ASI类型的测量方法) 干预条件。 迫切需要系统地评估治疗甲基苯丙胺使用的战略。 精神错乱。因此，该项目响应了NIDA的请求(RFA-DA-09-013)，以开发和评估有效的 以运动为基础的成瘾干预。

Project Summary/Abstract Description of the Project: This five-year study will assemble data on the efficacy of aerobic exercise for the treatment of methamphetamine dependence in a population of 150 individuals seeking treatment at Cri-Help residential drug treatment program in Los Angles. After signing consent and satisfying all inclusion/exclusion requirements, participants will be enrolled into the study and undergo baseline assessments during approximately two weeks of treatment as usual. After randomization, participants will enter the Exercise condition (n=75) or the control (Health Education; n=75) condition for an 8-week intervention duration. Incentives for participation in either condition activity (thrice weekly) are fixed at $10 per session. Of the 150 total participants, 30 voluntary participants will be part of a brain imaging substudy. The objective of the imaging substudy is to determine possible brain mechanisms associated with hypothesized effects of exercise on treatment outcomes. The primary goal of the study is to rigorously and comprehensively determine whether inclusion of a aerobic exercise within a residential program improves treatment outcomes in terms of reduced methamphetamine use during the first 12 weeks post discharge and 26 week follow up, as well as to characterize effects of exercise on health, psychiatric symptoms and cognition compared to the control (education) group pre/post intervention. Aims of the study are: Aim 1. To characterize effects of an aerobic exercise intervention ("Exercise") compared to health education ("Education") in terms of drug use after discharge from residential drug treatment in a population of MA- dependent individuals. Aim 2. To characterize effects of Exercise on MA craving and negative affective states including anxiety, depression, anhedonia, and stress reactivity among participants in residential treatment for MA dependence. Aim 3. To characterize effects of Exercise on neurocognitive functioning. Aim 4. To characterize variations in health-related outcomes among participants in the Exercise condition compared with those in the Education condition. Aim 5. To examine changes in dopamine D2/D3 receptor availability in abstinent MA-dependent participants assigned to an Exercise group compared to a subsample of participants in an Education (control) group (n = 15 per group). Aim 6. To examine differences in addiction-related behaviors (per ASI-type measures) according to intervention condition. There is a critical need for systematic evaluation of strategies for treating methamphetamine use disorders. Thus, this project responds to NIDA request (RFA-DA-09-013) to develop and evaluate an effective exercise-based intervention for addiction.