Stretchable, Biodegradable, and Self-Healing Semiconductors for Wearable and Implantable Sensors

用于可穿戴和植入式传感器的可拉伸、可生物降解和自我修复的半导体

• 批准号: 8954687
• 负责人: Darren J Lipomi
• 金额: $ 219.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8954687
• 关键词: Award; Biochemical; Biocompatible; Biological; Carbon; Chemicals; Coin; Device or Instrument Development; Devices; Disease; Elasticity; Electronics; Engineering; Goals; Health; Health Sciences; Healthcare; Intracranial Pressure; Measures; Mechanics; Methodology; Microfabrication; Modality; Modeling; Molecular; Monitor; Phase; Physiological; Polymer Chemistry; Polymers; Property; Prosthesis; Prunella vulgaris; Rattus; Research; Research Design; Retina; Semiconductors; Signal Transduction; Skin; Synthesis Chemistry; Telemetry; Tissues; Toxic effect; Transducers; Traumatic Brain Injury; United States National Institutes of Health; Wireless Technology; base; biomaterial compatibility; elastomeric; experience; human tissue; implantable device; implanted sensor; instrument; nanofabrication; polymerization; pressure; prevent; public health relevance; repaired; sensor

 DESCRIPTION (provided by applicant): This project aims to create a new class of semiconducting polymers for applications in wearable and implantable healthcare that-in contrast to all other research on "electronic skin"-will actually have properties inspired by biological tissue: extreme elasticity, biodegradability, and the ability to self-heal. The goal of organic bioelectronics is to detect and treat disease by using signal transducers based on organic conductors and semiconductors in wearable and implantable devices. Except for the carbon framework of these otherwise versatile materials, they have essentially no properties in common with biological tissue: electronic polymers are typically stiff and brittle, and do not degrade under physiological conditions. Seamless integration with soft, biodegradable, and self-healing tissue has thus not yet been realized. In Phase I of this project, we will develop a modular synthetic methodology based on segmented polymerization of semiconducting segments and biodegradable elastomeric segments. Phase II will characterize the properties of this new class of materials, which will be the first polymeric semiconductors to have the mechanical properties of human tissue, the first known semiconductors capable of self-repair, and the first organic semiconductors that can degrade under physiological conditions into biocompatible byproducts, which will be established in a rat model. Phase III will use the synthetic materials as transducers of chemical, biomolecular, mechanical, and electrical signals in several modalities as proof-of-concept devices, including skin-like pressure sensors for instrumented prostheses, biochemical sensors for wearable health monitors, and photodetectors for artificial retinas. Phase III will culminate in the demonstration of an implantable epidural pressure sensor for continuous monitoring of intracranial pressure (ICP). The long-term goal of this research is to endow these devices with the capability of wireless power and telemetry. The strength of the proposal is its vertically integrated strategy that combines molecular engineering and synthetic chemistry with determination of biodegradability and biocompatibility, the fabrication of devices, and their use in detecting physiological signals relevant to a range of diseases. The proposed research will build on my documented experience executing and directing projects in an especially broad range of topics: total synthesis of medicinally active compounds, micro- and nanofabrication of electronic devices, and development of stretchable materials and skin-like sensors for applications in implantable health monitoring. I coined the term "Molecularly Stretchable Electronics" to describe the research of my group, which is becoming internationally recognized as a leader in the mechanical properties of functional electronic polymers. The NIH Director's New Innovator Award would jumpstart my group's progress toward the long-term goal of my research: designing soft electronic materials specifically for applications in the health sciences.

 描述（由申请人提供）：该项目旨在创建一类新的半导体聚合物，用于可穿戴和植入式医疗保健，与所有其他关于“电子皮肤”的研究相反，它实际上具有受生物组织启发的特性：极端弹性，生物降解性和自我修复能力。有机生物电子学的目标是通过在可穿戴和可植入设备中使用基于有机导体和半导体的信号换能器来检测和治疗疾病。除了这些多用途材料的碳框架之外，它们基本上没有与生物组织相同的特性：电子聚合物通常是硬而脆的，并且在生理条件下不会降解。因此，与柔软的、可生物降解的和自愈合的组织的无缝整合尚未实现。在该项目的第一阶段，我们将开发一种基于半导体片段和可生物降解弹性体片段的分段聚合的模块化合成方法。第二阶段将表征这类新材料的特性，这将是第一个具有人体组织机械特性的聚合物半导体，第一个已知的能够自我修复的半导体，以及第一个可以在生理条件下降解为生物相容性副产品的有机半导体，这将在大鼠模型中建立。第三阶段将使用合成材料作为化学，生物分子，机械和电信号的转换器，以几种形式作为概念验证设备，包括用于仪器假体的皮肤压力传感器，用于可穿戴健康监测器的生化传感器，以及用于人工视网膜的光电探测器。第三阶段将最终演示用于连续监测颅内压（ICP）的植入式硬膜外压力传感器。本研究的长期目标是赋予这些设备无线供电和遥测的能力。该提案的优势在于其垂直整合战略，该战略将分子工程和合成化学与生物降解性和生物相容性的测定，设备的制造及其在检测与一系列疾病相关的生理信号中的应用相结合。拟议的研究将建立在我在一个特别广泛的主题执行和指导项目的记录经验的基础上：药用活性化合物的全合成，电子设备的微纳米纤维，以及可拉伸材料和皮肤传感器的开发，用于植入式健康监测。我创造了“分子可拉伸电子”这个术语来描述我的团队的研究，该团队正在成为国际公认的功能电子聚合物机械性能的领导者。美国国立卫生研究院院长的新创新者奖将推动我的团队朝着我的研究长期目标前进：设计专门用于健康科学的软电子材料。