Buprenorphine Facilitated Access and Supportive Treatment in Former Inmates

丁丙诺啡促进前囚犯获得和支持治疗

• 批准号: 8879087
• 负责人: Aaron D Fox
• 金额: $ 3.04万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8879087
• 关键词: Address; Aftercare; Alcohol or Other Drugs use; Applications Grants; Appointment; Award; Behavior Therapy; Buprenorphine; Caring; Cessation of life; Cluster Analysis; Communities; Counseling; Criminal Justice; Data; Development Plans; Drug usage; Education; Educational Intervention; Effectiveness; Elements; Foxes; Funding; Goals; Grant; HIV Infections; HIV risk; Healthcare; Healthcare Systems; Heroin Users; Imprisonment; Individual; Intervention; Intervention Studies; Interview; Knowledge; Lead; Link; Medical; Medical Records; Mentors; Mentorship; Modeling; Opiate Addiction; Opioid; Outcome; Overdose; Participant; Process Measure; Qualitative Methods; Randomized; Randomized Controlled Trials; Relapse; Research; Research Personnel; Research Project Grants; Risk; Risk Behaviors; Services; Site; Structure; Telephone; Testing; Training; Treatment outcome; United States National Institutes of Health; Urine; Visit; base; career; career development; design; effective therapy; experience; high risk; improved; individualized medicine; multidisciplinary; peer; prevent; primary outcome; randomized trial; secondary outcome; social; social cognitive theory

DESCRIPTION (provided by applicant): With the career goal of becoming an independent investigator, Dr. Aaron Fox describes a mentored research project and specific career development plan, which will prepare him to study interventions that improve treatment of opioid dependence post-incarceration. Following release from correctional facilities, opioid-dependent former inmates are at high risk of relapse to drug use, HIV-infection, and overdose-related death. Buprenorphine treatment for opioid dependence is effective, but underutilized, which makes behavioral interventions that encourage treatment critical. This proposal aims to: 1) determine the barriers to and facilitators of initiating buprenorphine treatment post-incarceration for opioid-dependent former inmates, 2) to tailor an intervention, using peer mentorship, to provide BUPrenorphine Facilitated Access and Supportive Treatment (BUP-FAST) to former inmates, and 3) to pilot test the feasibility and effectiveness of BUP-FAST at increasing initiatio of buprenorphine treatment. With guidance from a multidisciplinary team of expert mentors, Dr. Fox will conduct semi-structured interviews with opioid-dependent former inmates using Social Cognitive Theory as a theoretical framework to understand barriers to and facilitators of buprenorphine treatment. Based on these findings, he will tailor a previously developed intervention to encourage initiation of buprenorphine treatment by using peer mentors and targeting former inmates. The resulting intervention, BUP-FAST, will have specific components that are determined by applying Social Cognitive Theory to our findings, but we anticipate that peer mentors will provide: buprenorphine education, facilitated access to buprenorphine treatment, accompaniment to appointments, and supportive counseling. To pilot test BUP-FAST for feasibility and effectiveness, we will conduct a pilot randomized trial of BUP-FAST (vs. simple referral to buprenorphine treatment) collecting data on process measures to test feasibility and examining initiation of buprenorphine treatment to pilot test effectiveness. We hypothesize that compared to simple referral participants randomized to BUP-FAST will be more likely to initiate buprenorphine treatment. Subsequently, we will submit an R01 grant application to fully examine the effectiveness of BUP-FAST at improving buprenorphine treatment outcomes and reducing HIV-risk behaviors, opioid use, and re-incarceration in a multi-site randomized controlled trial. During the award period, Dr. Fox will pursue training in advanced qualitative methods, design of behavioral interventions, hierarchical modeling (for analysis of clustered data), and will gain experience in health care linkage following incarceration. With completion of these activities, along with intensive mentorship, Dr. Fox will be well prepared to fully test BUP-FAST and for his career goal of becoming an independent investigator.

描述（由申请人提供）：Aaron Fox博士的职业目标是成为一名独立研究者，他描述了一个受指导的研究项目和具体的职业发展计划，这将为他研究改善监禁后阿片类药物依赖治疗的干预措施做好准备。从教养所释放后，依赖阿片类药物的前囚犯再次吸毒、感染艾滋病毒和与过量有关的死亡的风险很高。丁丙诺啡治疗阿片类药物依赖是有效的，但未充分利用，这使得鼓励治疗的行为干预至关重要。本提案旨在：1)确定监禁后启动丁丙诺啡治疗的障碍和促进因素