New Strategies and Challenges in Lung Proteomics and Metabolomics

肺蛋白质组学和代谢组学的新策略和挑战

• 批准号: 8911120
• 负责人: RUSSELL Paul BOWLER
• 金额: $ 0.5万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8911120
• 关键词: Address; American; Biological; Chest; Cities; Colorado; Communities; Databases; Disease; Educational workshop; Environment; Environmental Impact; Epithelial; Exposure to; Genetic; Genomics; Health; Heart Diseases; Hematological Disease; Informatics; Institution; International; Knowledge; Lead; Liquid substance; Location; Lung; Lung diseases; Mass Spectrum Analysis; Mucous body substance; National Heart, Lung, and Blood Institute; Participant; Physicians; Preparation; Procedures; Proteins; Proteome; Proteomics; Publishing; Recording of previous events; Research; Research Personnel; Respiration Disorders; Sampling; Scientist; Societies; Techniques; Vascular blood supply; Work; abstracting; aqueous; data integration; follower of religion Jewish; improved; interest; meetings; metabolomics; minority trainee; operation; public health relevance; small molecule

 DESCRIPTION (provided by applicant): Metabolomics and Proteomics are two rapidly evolving, cutting edge techniques to simultaneously study large numbers of small molecules and proteins. The NHLBI has increasingly supported metabolomics and proteomics research initiatives for heart, lung, and blood diseases; however, there have been no lung specific initiatives. Furthermore, the lung presents unique challenges because of a unique mucus and aqueous epithelial barrier with constant exposure to the external environment as well as a vasculature that filters nearly the entire blood supply. These features create some unmet research challenges for metabolomics and proteomics such as: unique composition and sample preparation of lung epithelial lining fluid, the environmental impact on lung metabolites, a lack o Informatics approaches to shared databases for the lung, and difficulties in Integration of data across genetic and genomic databases. This meeting will address these challenges by bringing together a large diverse group of senior and junior investigators who work on lung proteomics and metabolomics. The meeting will take place in Denver, Colorado at National Jewish Health, an institution that is well known in the pulmonary research community and has a 100+ year history of supporting pulmonary research. The location is easily accessible to many participants though a centrally located airport with non-stop flights to many North American cities. The organizers plan to gain wide degree of support from other relevant institutions such as the American Thoracic Society, Colorado Biological Mass Spectrometry Society, etc. We plan to seek support to publish to findings The overall objectives of this meeting are: 1) Fill a knowledge gap in lung metabolomics and proteomics 2) Stimulate conversations and cross-pollination between pulmonary research scientists, mass spectrometists, and biostatisticians. 3) To initiate a dialogue between clinician-scientists and researchers interested in pulmonary pathobiology. 4) To educate pulmonary scientists about the potential cross-talk between the environment and the lung 5) Provide an international forum for leading clinicians and researchers to exchange ideas relating to lung proteomics and metabolomics. 6) Stimulate new perspectives and further research in pulmonary proteomics and metabolomics in health and disease determine if and how the alteration in the lung proteome or metabolme leads to or alters respiratory disorders 7) To create an environment that will lead to sustained interest among trainees 8) Create standardized operation procedures that can be shared among research groups to improved generalizability of research.

 描述(申请人提供)：代谢组学和蛋白质组学是两种快速发展的、同时研究大量小分子和蛋白质的尖端技术。NHLBI越来越多地支持心脏、肺和血液疾病的代谢组学和蛋白质组学研究倡议；然而，还没有专门针对肺的倡议。此外，肺面临着独特的挑战，因为独特的粘液和房水上皮屏障不断暴露在外部环境中，以及过滤几乎整个血液供应的血管系统。这些特点给代谢组学和蛋白质组学带来了一些尚未解决的研究挑战，例如：肺上皮衬里液体的独特成分和样品制备、对肺代谢物的环境影响、缺乏用于肺的共享数据库的信息学方法，以及跨基因和基因组数据库的数据整合的困难。这次会议将通过聚集一大批从事肺蛋白质组学和代谢组学工作的高级和初级研究人员来应对这些挑战。会议将在科罗拉多州丹佛市的国家犹太人健康中心举行，这是一家在肺部研究界很有名气的机构，在支持肺部研究方面已有100多年的历史。通过位于中心位置的机场，许多参与者可以很容易地到达该位置，该机场有直飞北美许多城市的航班。主办方计划获得其他相关机构的广泛支持，如美国胸科学会、科罗拉多州生物质谱学学会等。我们计划寻求支持，以发表本次会议的发现。本次会议的总体目标是：1)填补肺部代谢组学和蛋白质组学的知识空白；2)促进肺部研究科学家、质谱学家和生物统计学家之间的对话和交叉授粉。3)发起临床科学家和对肺部病理生物学感兴趣的研究人员之间的对话。4)教育肺部科学家有关环境和肺部之间潜在的相互作用5)为领先的临床医生和研究人员提供一个国际论坛，以交流与肺蛋白质组学和代谢组学有关的想法。6)激发健康和疾病中肺蛋白质组学和代谢组学的新视角和进一步研究，确定肺蛋白质组或代谢物的变化是否以及如何导致或改变呼吸系统疾病7)创造一个将导致受训者持续兴趣的环境8)创建可在研究小组之间共享的标准化操作程序，以提高研究的普适性。