Genetic Risk for Smallpox Vaccine Related to Myocarditis

群体遗传学分析计划的重点是人类遗传变异的差异免疫反应的疫苗接种或感染人类病原体。目标是复制先前确定的人类基因型-表型关联，并阐明与免疫结果相关的已验证遗传变异的功能相关性。研究将集中在一个或多个新兴或重新出现的组I， II，或III列在http://www3.niaid.nih.gov/topics/emerging/list.htm传染因子。这些信息将有助于确定个体风险因素，将扩大我们对适用于广泛人类疾病的免疫机制的理解，并将有助于确定风险和免疫的生物标志物，从而可能导致新的感染或疫苗反应诊断测试。

The Population Genetics Analysis program is focused on human genetic variation underlying differential immune responses to vaccination against or infection by human pathogens. The goals are to replicate previously identified human genotype-phenotype associations and elucidate the functional relevance of the validated genetic variants that correlate with immune outcome. Research will focus on one or more of the emerging or re-emerging Group I, II, or III infectious agents listed at http://www3.niaid.nih.gov/topics/emerging/list.htm. This information will help to identify individual risk factors, will expand our understanding of immune mechanisms applicable to a broad range of human diseases, and will help define biomarkers of risk and immunity that might lead to novel diagnostic tests of infection or vaccine response. This contract will study the genetic risk for smallpox vaccine related to myocarditis