TAS::75 0893::TAS THIOAPTAMER CAPTURE FOR ADDICTION-RELEVANT PROTEINS

TAS::75 0893::TAS 硫适体捕获成瘾相关蛋白质

• 批准号: 8113085
• 负责人: ROSS DURLAND
• 金额: $ 20万
• 依托单位: AM BIOTECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8113085
• 关键词: Affinity; Binding; Biotechnology; Cells; Chemicals; Contracts; Development; Drug Addiction; Evolution; Libraries; Ligands; Methods; Modification; Neurosciences; Phase; Proteins; Reagent; Specificity; Variant; addiction; aptamer; base; phosphorodithioic acid

AM Biotechnologies (AM) will develop renewable thioaptamer protein capture reagents to ten proteins related to drug addiction. Thioaptamers are a type of aptamer containing phosphorodithioate linkages and other modifications that have excellent affinity and specificity for proteins. Because of the unique chemical composition of thioaptamers, they cannot be developed using the Systematic Evolution of Ligands by Exponential (SELEX) amplification method.

AM生物技术公司（AM）将开发可再生的硫腺苷蛋白捕获试剂，以捕获与药物成瘾相关的十种蛋白质。硫胺适配体是一类含有磷二硫酸键和其他修饰的适配体，对蛋白质具有良好的亲和力和特异性。由于硫胺适配体的独特化学组成，它们不能用指数扩增法进行配体的系统进化。