Epoch Telemetry System for Long-Term Monitoring of Biopotentials

用于长期监测生物电势的 Epoch 遥测系统

• 批准号: 8840669
• 负责人: F. Edward DUDEK
• 金额: $ 78.08万
• 依托单位: EPITEL, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8840669
• 关键词: Address; Adult; Animal Disease Models; Animal Model; Animals; Applications Grants; Basic Science; Blood Pressure; Brain; Brain Neoplasms; Cardiac; Childhood; Clinic; Complex; Coupled; Data; Devices; Disease; Electrocardiogram; Electrocorticogram; Electrodes; Electroencephalography; Electrophysiology (science); Epilepsy; Family; Funding; Goals; Health; Heart Diseases; Hour; Housing; Human; Implant; Implanted Electrodes; Individual; Intracranial Pressure; Left ventricular structure; Light; Measurement; Modeling; Monitor; Mus; Nature; Neonatal; Newborn Animals; Obesity; Phase; Population; Progressive Disease; Rattus; Reporting; Research; Research Personnel; Rodent; Rodent Model; Sales; Seizures; Signal Transduction; Sleep; Solutions; Spinal Cord; Staging; Structure; System; Technology; Telemetry; Temperature; Time; Transducers; Translational Research; Translations; Traumatic Brain Injury; Video Recording; Weaning; Wireless Technology; Work; base; cranium; data acquisition; data visualization; density; design; digital; drug discovery; experience; flexibility; human disease; instrument; neuromuscular; pre-clinical; pressure; programs; pup; tool

DESCRIPTION (provided by applicant): Epoch Telemetry System for Long-Term Monitoring of Biopotentials ABSTRACT Epoch" is a wireless, multi- channel biopotential recording system designed for small animal translational research models of human disease developed in Phase I and II. Obtaining long- term continuous recordings from animal models of disease is a critical component of translational research aimed at developing new therapies for debilitating disorders, such as epilepsy, heart disease, brain tumor, traumatic brain injury, and obesity. Many immature- and adult-rodent models have recently been developed that are surrogates for human Epitel Epoch Wireless 6 Channel Biopotential Recording System manifestations of progressive disease in the pediatric and adult populations. While tethered (i.e., "wired") recordings of biopotentials can be obtained periodically (i.e., for minutes to a few hours per session in immature rodents), these recordings have problems associated with the small size of rats and mice. Recordings can be obtained for weeks or months at a time from adult rats with either tethered or telemetric recording systems; however, both of these systems have limitations. The younger or smaller the animal, the more difficult it is to obtain adequate recordings, and it is nearly impossible to obtain prolonged, continuous recordings - especially in mice. A wireless, multi- modal, multi-channel solution for recording biopotentials for long periods in mice has not yet been made available in the marketplace. Epitel will address this need in Phase IIb by broadly expanding the unimodal electrophysiology capabilities of the Epoch system to include multimodal transducers. The project has 3 main goals: 1) to develop wireless blood pressure and pressure-volume transducers for cardiac applications, 2) to provide our customers the ability to implant multiple electrodes targeting deep brain structures with stereotactic precision, and 3) to enable simultaneous recording from up to four animals in a single cage. Epoch is the only wireless system able to make up to 6 channels of biopotential recordings in not only adult rodents, but also neonatal animals that weigh as little as 6 grams. The fundamental principle of the Epoch recording system is that the capacitive- coupled technology. The small size (<1 g) and low profile (<1 cc) of the telemetry unit will allow multiple rats or mice to be recorded simultaneously, enabling continuous cortical and deep brain electrophysiology, temperature, blood pressure and pressure-volume directly from the left ventricle, intracranial pressure, electrocardiogram, electromyogram, and video recordings uninterrupted for up to 6 months. The long-term goal is for researchers to be able to use the Epoch system in translational research to develop new therapies for animal models of progressive human disease. Epoch is the only system capable of recording biopotentials from adult rats and mice and neonatal animals (P6 rat; P8 mouse) continuously through weaning into adulthood to provide a full report of the progressive nature of disease, which is important for translation of a potential therapy to the clinic. The simplicity of the Epoch transmitter makes it easier to develop sophisticated, fully instrumented small animal models of human disease.

描述（由申请人提供）：用于生物电长期监测的 Epoch 遥测系统 摘要 Epoch 是一种无线、多通道生物电记录系统，专为 I 期和 II 期开发的人类疾病小动物转化研究模型而设计。从动物疾病模型中获得长期连续记录是转化研究的重要组成部分，旨在开发衰弱性疾病的新疗法，例如癫痫、心脏病、脑肿瘤、 脑外伤和肥胖。最近开发了许多未成熟和成年啮齿动物模型，这些模型可以替代人类 Epitel Epoch 无线 6 通道生物电记录系统在儿科和成人中表现出的进行性疾病。虽然可以定期获得生物电的系留（即“有线”）记录（即，在未成熟的啮齿动物中每次持续几分钟到几个小时），但这些记录 与大鼠和小鼠体型较小有关的问题。通过系绳或遥测记录系统，可以从成年大鼠身上一次获得数周或数月的记录；然而，这两种系统都有局限性。动物越年轻或体型越小，获得足够的记录就越困难，而且几乎不可能获得长时间、连续的记录——尤其是在小鼠身上。用于记录生物电势的无线、多模式、多通道解决方案 长时间 小鼠中尚未在市场上销售。 Epitel 将通过广泛扩展 Epoch 系统的单模态电生理学功能以包括多模态传感器来满足 IIb 阶段的这一需求。该项目有 3 个主要目标：1) 开发用于心脏应用的无线血压和压力容量传感器，2) 使我们的客户能够以立体定向精度植入针对大脑深层结构的多个电极，3) 能够同时记录单个笼子中最多四只动物的数据。 Epoch 是唯一能够对成年啮齿动物以及体重低至 6 克的新生动物进行多达 6 个通道的生物电势记录的无线系统。 Epoch记录系统的基本原理是电容耦合技术。遥测单元的小尺寸（<1 g）和薄型（<1 cc）将允许多个 同时记录大鼠或小鼠的皮层和深部脑电生理、直接来自左心室的温度、血压和压力容积、颅内压、心电图、肌电图和视频记录，最长可达 6 个月不间断。长期目标是让研究人员能够在转化研究中使用 Epoch 系统，为人类进行性疾病的动物模型开发新疗法。 Epoch 是唯一能够记录成年大鼠、小鼠和新生动物（P6 大鼠；P8 小鼠）从断奶到成年期间的生物电的系统，以提供疾病进展性质的完整报告，这对于将潜在疗法转化为临床非常重要。 Epoch 发射器的简单性使得开发复杂的、仪器齐全的人类疾病小动物模型变得更加容易。