Epoch Telemetry System for Long-Term Monitoring of Biopotentials

“Epoch”是一种无线、多通道生物电位记录系统，专为I期和II期开发的人类疾病的小动物转化研究模型而设计。从动物疾病模型中获得长期连续的记录是旨在开发衰弱性疾病（如癫痫、心脏病、脑肿瘤、创伤性脑损伤和肥胖）新疗法的转化研究的关键组成部分。近年来，许多未成熟和成年啮齿动物模型被开发出来，作为儿童和成人群体进行性疾病的人类Epitel Epoch无线6通道生物电位记录系统的替代品。虽然拴绳（即“有线”）的生物电位记录可以定期获得（即，在未成熟的啮齿动物中，每次记录几分钟到几个小时），但这些记录存在与大鼠和小鼠体型小有关的问题。利用系留或遥测记录系统，可以从成年大鼠一次获得数周或数月的记录；然而，这两种系统都有局限性。动物越年轻或越小，获得足够的记录就越困难，而且几乎不可能获得长时间、连续的记录——尤其是在老鼠身上。用于长时间记录生物电位的无线、多模式、多通道解决方案

DESCRIPTION (provided by applicant): Epoch Telemetry System for Long-Term Monitoring of Biopotentials ABSTRACT Epoch" is a wireless, multi- channel biopotential recording system designed for small animal translational research models of human disease developed in Phase I and II. Obtaining long- term continuous recordings from animal models of disease is a critical component of translational research aimed at developing new therapies for debilitating disorders, such as epilepsy, heart disease, brain tumor, traumatic brain injury, and obesity. Many immature- and adult-rodent models have recently been developed that are surrogates for human Epitel Epoch Wireless 6 Channel Biopotential Recording System manifestations of progressive disease in the pediatric and adult populations. While tethered (i.e., "wired") recordings of biopotentials can be obtained periodically (i.e., for minutes to a few hours per session in immature rodents), these recordings have problems associated with the small size of rats and mice. Recordings can be obtained for weeks or months at a time from adult rats with either tethered or telemetric recording systems; however, both of these systems have limitations. The younger or smaller the animal, the more difficult it is to obtain adequate recordings, and it is nearly impossible to obtain prolonged, continuous recordings - especially in mice. A wireless, multi- modal, multi-channel solution for recording biopotentials for long periods in mice has not yet been made available in the marketplace. Epitel will address this need in Phase IIb by broadly expanding the unimodal electrophysiology capabilities of the Epoch system to include multimodal transducers. The project has 3 main goals: 1) to develop wireless blood pressure and pressure-volume transducers for cardiac applications, 2) to provide our customers the ability to implant multiple electrodes targeting deep brain structures with stereotactic precision, and 3) to enable simultaneous recording from up to four animals in a single cage. Epoch is the only wireless system able to make up to 6 channels of biopotential recordings in not only adult rodents, but also neonatal animals that weigh as little as 6 grams. The fundamental principle of the Epoch recording system is that the capacitive- coupled technology. The small size (<1 g) and low profile (<1 cc) of the telemetry unit will allow multiple rats or mice to be recorded simultaneously, enabling continuous cortical and deep brain electrophysiology, temperature, blood pressure and pressure-volume directly from the left ventricle, intracranial pressure, electrocardiogram, electromyogram, and video recordings uninterrupted for up to 6 months. The long-term goal is for researchers to be able to use the Epoch system in translational research to develop new therapies for animal models of progressive human disease. Epoch is the only system capable of recording biopotentials from adult rats and mice and neonatal animals (P6 rat; P8 mouse) continuously through weaning into adulthood to provide a full report of the progressive nature of disease, which is important for translation of a potential therapy to the clinic. The simplicity of the Epoch transmitter makes it easier to develop sophisticated, fully instrumented small animal models of human disease.