International Conference on Grampositive Pathogens

国际革兰氏阳性病原体会议

• 批准号: 8785549
• 负责人: PAUL D FEY
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-05 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785549
• 关键词: Adult; Antibiotic Resistance; Antibiotic-Associated Colitis; Antibiotics; Award; Bacteria; Biology; Cell Communication; Cell Wall; Cells; Clostridium difficile; Collaborations; Communities; Data; Enterocolitis; Environment; Epidemic; Epidemiology; Fees; Fostering; Funding; Gram-Negative Bacteria; Grant; Health care facility; Hospitals; Individual; Infection; Institution; International; Knowledge; Medical center; Membrane; Nebraska; Necrotizing fasciitis; Oral; Organism; Paris, France; Participant; Pathogenesis; Postdoctoral Fellow; Protein Biosynthesis; Protein Secretion; Protocols documentation; Regimen; Research; Research Personnel; Schools; Science; Scientist; Senior Scientist; Skin Tissue; Soft Tissue Infections; Staging; Travel; United States; Universities; Woman; base; career; graduate student; interest; meetings; member; methicillin resistant Staphylococcus aureus; mortality; novel therapeutics; pathogen; posters; public health relevance; symposium; undergraduate student

DESCRIPTION (provided by applicant): The International Conference on Gram-Positive Pathogens (ICGPP) brings together scientists at all stages of their careers to exchange ideas and strategies based on their shared interests in Gram- positive pathogens. This conference, initially held in 2006 and then continued in 2008, 2010, and 2012 as a result of participant enthusiasm, grew out of collaborations between investigators at the University of Nebraska Medical Center and other academic institutions in the great plains region of the United States. The overarching benefit of ICGPP is the opportunity for investigators to share the science, approaches, and protocols that are unique to Gram-positive organisms in contrast to Gram- negative bacteria. While Gram-positive pathogens cause a myriad of unique infections, ranging from antibiotic-associated colitis to necrotizing fasciitis, fundamental aspects of activities that include protein secretion across single membranes, cell wall biosynthesis and protein anchoring, and cell-cell communication are shared between this group of medically important pathogens. The impact of Gram-positive infections continues to grow and antibiotic resistance remains a significant threat. As an example, Clostridium difficile enterocolitis, once primarily associated with antibiotic use in hospitals, is now found in young, healthy adults that do not have an epidemiological relationship to a healthcare facility. Recent data suggests that infections caused by C. difficile are the leading cause of mortality among antibiotic-resistant bacteria in the US. In addition, community-acquired methicillin- resistant Staphylococcus aureus (CA-MRSA) strain USA300 has reached epidemic levels and is causing skin and soft tissue infections in schools, locker rooms, and hospitals in otherwise healthy individuals. This R13 application is requesting funds to support the ICGPP to be held in Omaha, NE during the dates of October 12-15, 2014. Our current organizing committee is comprised of eight members from various academic institutions, and all are past attendees and have been involved in the planning stages of this conference. Although other meetings exist in the US that present various aspects of bacterial pathogenesis or prokaryotic biology, this is the only meeting focusing specifically on Gram-positive pathogenesis and biology, and which provides a collegial and supporting environment that fosters interactions between established investigators and junior scientists. Young scientists have the option of presenting their research in either poster or oral format and importantly, in 2012, 40 trainees gave oral research presentations. Five internationally known scientists have already agreed to give keynote presentations at the 2014 ICGPP: Drs. Andrew Camilli (Tufts University), Jean Lee (Harvard University and Brigham and Women's Hospital), Bruno Dupuy (Institut Pasteur in Paris, France), Darren Higgins (Harvard University), and Kelly Doran (San Diego State University). To keep registration fees low for participants and to encourage the engagement of young investigators, we request funds to support travel of our five keynote speakers and for 17 travel grants that will be awarded to pre and post-doctoral trainees.

描述（由申请人提供）：国际革兰氏阳性病原体会议（ICGPP）汇集了科学家在他们的职业生涯的各个阶段，交流思想和战略的基础上，他们在革兰氏阳性病原体的共同利益。该会议最初于2006年举行，然后在2008年，2010年和2012年继续由于参与者的热情，来自内布拉斯加大学医学中心和美国大平原地区其他学术机构的研究人员之间的合作。ICGPP的首要好处是研究人员有机会分享与革兰氏阴性细菌相比革兰氏阳性生物所特有的科学、方法和方案。虽然革兰氏阳性病原体会引起无数独特的感染，从抗生素相关性结肠炎到坏死性筋膜炎，但这些活动的基本方面 包括蛋白质跨膜分泌、细胞壁生物合成和蛋白质锚定以及细胞间通讯。革兰氏阳性菌感染的影响继续增长，抗生素耐药性仍然是一个重大威胁。例如，艰难梭菌小肠结肠炎曾经主要与医院中的抗生素使用有关，现在在与医疗机构没有流行病学关系的年轻健康成年人中发现。最近的数据表明，由C。在美国，艰难梭菌是耐药性细菌死亡的主要原因。此外，社区获得的耐甲氧西林金黄色葡萄球菌（CA-MRSA）菌株USA 300已达到流行水平，并在学校、更衣室和医院中引起其他健康个体的皮肤和软组织感染。此R13申请要求提供资金，以支持将于2014年10月12日至15日在内布拉斯加州奥马哈举行的ICGPP。我们目前的组委会由来自不同学术机构的八名成员组成，他们都是过去的与会者，并参与了本次会议的规划阶段。虽然其他会议存在于美国，提出了细菌发病机理或原核生物学的各个方面，这是唯一的会议专门关注 革兰氏阳性的发病机制和生物学，并提供了一个合议和支持的环境，促进建立调查人员和初级科学家之间的互动。青年科学家可以选择以海报或口头形式介绍他们的研究，重要的是，2012年，40名受训人员作了口头研究介绍。五位国际知名科学家已同意在2014年ICGPP上发表主旨演讲：Andrew Camilli博士（塔夫茨大学）、Jean Lee博士（哈佛大学和布里格姆妇女医院）、Bruno Dupuy博士（法国巴黎巴斯德研究所）、Darren Higgins博士（哈佛大学）和Kelly Doran博士（圣地亚哥州立大学）。为了降低与会者的注册费，并鼓励年轻研究人员的参与，我们要求提供资金，以支持我们的五位主旨发言人的旅行，并为17名将授予博士前和博士后学员的旅行赠款。