Development of an Implantable On-Demand Drug Delivery Device for Behavioral Studies in Small Animals

开发用于小动物行为研究的植入式按需给药装置

• 批准号: 9047055
• 负责人: Forrest Payne
• 金额: $ 17.5万
• 依托单位: SFC FLUIDICS, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9047055
• 关键词: Advanced Development; Anesthesia procedures; Anesthetics; Animal Model; Animals; Behavior; Biocompatible; Blood; Bolus Infusion; Cannulas; Collaborations; Computer software; Data; Development; Devices; Dose; Drug Addiction; Drug Delivery Systems; Effectiveness; Ensure; Evaluation; Flavoring; Food; Funding; Genus Vanilla; Goals; Government; Human; Implant; Implantable Pump; Infusion procedures; Injection of therapeutic agent; Laboratories; Legal patent; Liquid substance; Marketing; Medical; Methohexital; Microfluidics; Modeling; Movement; Muscle Tonus; Persons; Pharmaceutical Preparations; Phase; Postoperative Period; Procedures; Proteins; Protocols documentation; Psychiatric Hospitals; Publications; Pump; Rattus; Recovery; Reflex action; Reinforcement Schedule; Research; Research Personnel; Secure; Self Administration; Signal Transduction; Silastic; Sodium; Specific qualifier value; Stream; Study models; System; Technology; Testing; Therapeutic; Time; Training; Universities; Veterinary Medicine; addiction; base; behavioral pharmacology; behavioral study; cost; design; drinking; external jugular vein; improved; medical schools; pre-clinical; programs; prototype; public health relevance; reinforcer; response; symposium; vapor

 DESCRIPTION (provided by applicant): The Specific Aim of this Phase I project is to prove the feasibility of using SFC Fluidics' patented microfluidic pumping technology to develop the RatPump, a low-cost, disposable, battery-operated, implantable, on-demand, tether-free drug delivery system. The RatPump will allow real-time wirelessly controlled delivery of drugs and therapeutics to animals for addiction and behavior research models. This implantable pumping system will have substantially improved operational capacities at a much lower cost as compared to current tethered and non- tethered drug delivery systems. During the last three months of Phase I, the RatPump will be implanted and tested in rats at the McLean Psychiatric Hospital at Harvard University. The following Phase I Tasks are designed to prove feasibility of this Specific Aim. Task 1: Integration of microfluidic components into an implantable, on-demand drug delivery device. (SFC Fluidics - Months 1-4) Task 2: Demonstration of controlled fluid movement ex vivo from the drug delivery system using specified test protocol. (SFC Fluidics - Months 5-6) Task 3: Demonstration of use of implanted RatPump showing ability to deliver drugs on- demand and remotely. (Harvard/McLean Medical School - Months 7-9) Phase II will focus on modifying the Phase I RatPump prototype based on the results of Phase I testing and iterative advanced development. By the end of Phase II, SFC Fluidics will have a final design RatPump system that will deliver on-demand doses of drugs and therapeutics with an accuracy of +/- 5%. The focus of our subcontractor in Phase II will be to improve his drug addiction models as enabled by the RatPump, and to provide those data in publications, scientific conferences, and collaborations in order to facilitate the use of the RatPump toward the advancement of drug addiction models in other laboratories.

 说明(申请人提供)：第一阶段项目的具体目标是证明使用SFC Fluidics的专利微流控泵技术开发RatPump的可行性，RatPump是一种低成本、一次性、电池供电、可植入、按需、无系绳的药物输送系统。RatPump将允许实时无线控制向动物输送药物和治疗药物，用于成瘾和行为研究模型。与目前的栓系和非栓系药物输送系统相比，这种植入式泵送系统将以低得多的成本大幅提高作业能力。在第一阶段的最后三个月，RatPump将在哈佛大学麦克莱恩精神病院的大鼠身上进行植入和测试。以下第一阶段任务旨在证明这一具体目标的可行性。任务1：将微流控部件集成到可植入的按需给药装置中。(SFC流体学-1-4个月)任务2：使用指定的测试方案演示受控液体从药物输送系统的体外流动。(SFC Fluidics-5-6个月)任务3：演示植入的RatPump的使用，显示有能力按需和远程输送药物。(哈佛/麦克莱恩医学院-7-9个月)第二阶段将根据第一阶段测试和迭代高级开发的结果，重点修改第一阶段RatPump原型。到第二阶段结束时，SFC Fluidics将拥有最终设计的RatPump系统，该系统将提供按需剂量的药物和治疗药物，准确率为+/-5%。我们分包商在第二阶段的重点将是改进他的由RatPump实现的药物成瘾模型，并在出版物、科学会议和合作中提供这些数据，以便促进RatPump的使用，以促进其他实验室的药物成瘾模型的发展。