Development of an Implantable On-Demand Drug Delivery Device for Behavioral Studies in Small Animals

 描述（由申请人提供）：该第一阶段项目的具体目标是证明使用SFC Fluidics的专利微流体泵送技术开发RatPump的可行性，RatPump是一种低成本、一次性、电池供电、可植入、按需、无系绳的药物输送系统。RatPump将允许实时无线控制药物和治疗药物向动物提供成瘾和行为研究模型。这种可植入泵送系统与目前的栓系和非栓系药物递送系统相比，将具有显著改善的操作能力和低得多的成本。在第一阶段的最后三个月里，RatPump将在哈佛大学姆克林精神病医院的老鼠身上进行植入和测试。以下第一阶段任务旨在证明该具体目标的可行性。任务1：将微流体组件集成到可植入的按需给药装置中。(SFC射流-第1-4个月）任务2：使用规定的试验方案证明药物输送系统的离体受控流体移动。(SFC射流-第5-6个月）任务3：证明使用植入式RatPump，显示按需和远程输送药物的能力。（哈佛/姆克林医学院-第7-9个月）第二阶段将侧重于根据第一阶段测试和迭代高级开发的结果修改第一阶段RatPump原型。到第二阶段结束时，SFC Fluidics将拥有最终设计的RatPump系统，该系统将提供按需剂量的药物和治疗剂，准确度为+/-5%。我们的分包商在第二阶段的重点将是改进RatPump支持的药物成瘾模型，并在出版物、科学会议和合作中提供这些数据，以促进RatPump的使用，促进其他实验室药物成瘾模型的发展。

 DESCRIPTION (provided by applicant): The Specific Aim of this Phase I project is to prove the feasibility of using SFC Fluidics' patented microfluidic pumping technology to develop the RatPump, a low-cost, disposable, battery-operated, implantable, on-demand, tether-free drug delivery system. The RatPump will allow real-time wirelessly controlled delivery of drugs and therapeutics to animals for addiction and behavior research models. This implantable pumping system will have substantially improved operational capacities at a much lower cost as compared to current tethered and non- tethered drug delivery systems. During the last three months of Phase I, the RatPump will be implanted and tested in rats at the McLean Psychiatric Hospital at Harvard University. The following Phase I Tasks are designed to prove feasibility of this Specific Aim. Task 1: Integration of microfluidic components into an implantable, on-demand drug delivery device. (SFC Fluidics - Months 1-4) Task 2: Demonstration of controlled fluid movement ex vivo from the drug delivery system using specified test protocol. (SFC Fluidics - Months 5-6) Task 3: Demonstration of use of implanted RatPump showing ability to deliver drugs on- demand and remotely. (Harvard/McLean Medical School - Months 7-9) Phase II will focus on modifying the Phase I RatPump prototype based on the results of Phase I testing and iterative advanced development. By the end of Phase II, SFC Fluidics will have a final design RatPump system that will deliver on-demand doses of drugs and therapeutics with an accuracy of +/- 5%. The focus of our subcontractor in Phase II will be to improve his drug addiction models as enabled by the RatPump, and to provide those data in publications, scientific conferences, and collaborations in order to facilitate the use of the RatPump toward the advancement of drug addiction models in other laboratories.