Mount Sinai Institutes for Clinical and Translational Sciences

西奈山临床和转化科学研究所

• 批准号: 8915386
• 负责人: Hugh A Sampson
• 金额: $ 12.71万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-14 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8915386
• 关键词: Caregivers; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Consultations; Country; Development; Doctor' s Degree; Environment; Fostering; Future; General Population; Goals; Grant; Health Benefit; Health Professional; Home environment; Hospitals; Information Networks; Institutes; Institution; Instruction; Laboratories; Mentors; Methodology; Participant; Patients; Procedures; Recruitment Activity; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Rewards; Scientific Advances and Accomplishments; Scientist; Structure; Technology; Therapeutic; Training; Training Support; Translating; Translational Research; Translations; bench to bedside; career development; clinical practice; improved; interdisciplinary collaboration; medical schools; multidisciplinary; novel; programs; standard of care

Despite great scientific advances over the past decade, the translation of these discoveries to the benefit of patients has been hampered by a number of traditional barriers. The overall goal of the Mount Sinai institutes of Clinical & Translational Sciences is to establish a new research paradigm at Mount Sinai, which will create an integrated multidisciplinary environment that will enable translation of cutting-edge research more quickly and easily from "bench-to-bedside-to-implementation" in the community; train and create an "academic home" for the clinical and translational investigators of tomorrow; and supply the governance, facilities, resources and opportunities needed to elevate the clinical research enterprise so that clinical investigators can take full advantage of Mount Sinai's Translational Research Institutes and potential collaborators in Mount Sinai Hospital and its affiliates, the School of Medicine and partnering institutions, and other CTSA programs around the country. This transformation will be achieved by fulfilling the following Specific Aims: (1) redesign the institutional research enterprise infrastructure and governance by integrating research functions across administrative, departmental and intellectual boundaries, enhancing and promoting interactions between basic scientists and clinical investigators, and streamlining administrative procedures to facilitate the start-up of clinical trials and the dissemination of results; (2) establish a Translational Discoveries Program to facilitate and expedite clinical research by providing consultation, oversight and facilities for clinical and translational research, engaging the surrounding community and our affiliates to rapidly translate health benefits to the general population, and developing new methodologies to improve clinical trial design and reduce participant burden; (3) train and support the translational investigators of tomorrow by overseeing a multi-disciplinary, doctoral degree-granting program in clinical and translational research for all health care professionals, developing a program to recruit, enhance career development and retain clinical and translational researchers, providing an academic home where new collaborations can be formulated; (4) establish an Experimental Therapeutics& Technologies Program to stimulate the development of new methodologies in clinical and translational research by developing an institution-wide mentored program to identify and develop novel clinical and translational research projects; and (5) establish an institution-wide biomedical information infrastructure that can connect basic researchers, clinical researchers, caregivers and laboratories with an integrated network of information. RELEVANCE (See instructions): The establishment ofthe Mount Sinai Institutes of Clinical & Translational Sciences would create an effective, efficient and centralized research administrative structure, foster and reward interdisciplinary collaborations, educate and retain the clinical and translational investigators of the future, enable translation of basic scientific discoveries into clinical practice, and deliver to our diverse community new therapies and a standard of care that would have been unimaginable even five years ago.

尽管在过去十年中取得了巨大的科学进步，但将这些发现转化为 患者一直受到许多传统障碍的阻碍。西奈山的总体目标是 临床与翻译科学研究所将在西奈山建立一个新的研究范式， 这将创造一个集成的多学科环境，使尖端技术 在社区中更快速、更轻松地进行从工作台到床边到实施的研究；培训和 为未来的临床和转化型研究人员创造一个“学术家园”；并提供 提升临床研究企业所需的治理、设施、资源和机会 临床研究人员可以充分利用西奈山的翻译研究所和潜力 西奈山医院及其附属机构、医学院和合作机构的合作者，以及 全国各地的其他CTSA项目。这一转变将通过实现以下几点来实现 具体目标：(1)通过整合重新设计机构研究企业基础设施和治理 跨行政、部门和智力边界的研究职能，增强和 促进基础科学家和临床研究人员之间的互动，简化管理 促进启动临床试验和传播结果的程序；(2)建立 翻译发现计划通过提供咨询来促进和加快临床研究， 临床和转化性研究的监督和设施，使周围社区和我们的 附属机构迅速将健康福利转化为普通民众，并开发新的方法来 改进临床试验设计，减轻参与者负担；(3)培训和支持翻译人员 未来的研究人员通过监督一个多学科的、授予临床和医学博士学位的项目 为所有卫生保健专业人员进行翻译研究，制定招聘计划，促进职业发展 开发和留住临床和翻译研究人员，提供一个新的学术家园 可以制定合作计划；(4)建立实验治疗和技术计划，以 促进临床和转化性研究中新方法的开发 机构范围的指导计划，以确定和开发新的临床和转化性研究项目； 以及(5)建立能够连接基础研究人员的机构范围的生物医学信息基础设施， 具有集成信息网络的临床研究人员、护理人员和实验室。 相关性(请参阅说明)： 西奈山临床与翻译科学研究所的成立将创造一个 有效、高效和集中的研究管理结构，促进和奖励跨学科 协作，教育和留住未来的临床和翻译研究人员，使翻译成为可能 将基本科学发现转化为临床实践，并为我们多样化的社区提供新的疗法和 即使在五年前，这种标准的护理也是不可想象的。

项目成果

Nutritional vitamin D supplementation and health-related outcomes in hemodialysis patients: a protocol for a systematic review and meta-analysis.

• DOI: 10.1186/s13643-015-0002-x
• 发表时间: 2015-02-21
• 期刊: Systematic reviews
• 影响因子: 3.7
• 作者: Mehrotra A;Leung WY;Joson T
• 通讯作者: Joson T

Understanding Career Success and Its Contributing Factors for Clinical and Translational Investigators.

• DOI: 10.1097/acm.0000000000000979
• 发表时间: 2016-04
• 期刊: Academic medicine : journal of the Association of American Medical Colleges
• 作者: Robinson GF;Schwartz LS;DiMeglio LA;Ahluwalia JS;Gabrilove JL
• 通讯作者: Gabrilove JL

Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection.

• DOI: 10.1186/1471-2105-14-s6-s1
• 发表时间: 2013
• 期刊: BMC bioinformatics
• 影响因子: 3
• 作者: Zaslavsky E;Nudelman G;Marquez S;Hershberg U;Hartmann BM;Thakar J;Sealfon SC;Kleinstein SH
• 通讯作者: Kleinstein SH

Low Dietary Intake of Vitamin D and Vitamin D Deficiency in Hemodialysis Patients.

• DOI: 10.4172/2161-0959.1000166
• 发表时间: 2014-05
• 期刊: Journal of nephrology & therapeutics
• 作者: Maria Krassilnikova;K. Ostrow;A. Bader;P. Heeger;A. Mehrotra

Altered olfactory processing and increased insula activity in patients with obsessive-compulsive disorder: An fMRI study.

• DOI: 10.1016/j.pscychresns.2017.01.012
• 发表时间: 2017-04-30
• 期刊: Psychiatry research. Neuroimaging
• 作者: Berlin HA;Stern ER;Ng J;Zhang S;Rosenthal D;Turetzky R;Tang C;Goodman W
• 通讯作者: Goodman W