Ambulatory assessment of physical pain, emotional distress and alcohol use

身体疼痛、情绪困扰和饮酒的动态评估

• 批准号: 8909609
• 负责人: Ryan W Carpenter
• 金额: $ 3.47万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8909609
• 关键词: Absence of pain sensation; Address; Adult; Affect; Alcohol abuse; Alcohol consumption; Alcohols; Analgesics; Anxiety Disorders; Basic Science; Cellular Phone; Data; Development; Disease; Distress; Event; Expectancy; Goals; Hyperalgesia; Individual; Individual Differences; Intervention; Knowledge; Laboratories; Lead; Life; Link; Methods; Modeling; Mood Disorders; Negative Reinforcements; Opioid; Opioid Analgesics; Outpatients; Pain; Participant; Physical assessment; Prevalence; Prevention strategy; Process; Recruitment Activity; Reporting; Research; Research Project Grants; Risk; Sampling; Severities; Stimulus; Stress; System; Target Populations; Testing; Translational Research; Withdrawal; alcohol effect; alcohol expectancy; alcohol research; alcohol use disorder; chronic back pain; chronic pain; cost; drinking; emotional distress; endogenous opioids; experience; improved; prescription opioid; public health relevance; reduced alcohol use; relating to nervous system; response; therapy development

 DESCRIPTION (provided by applicant): The goal of this project is to test a theoretical framework for why individuals with chronic pain consume alcohol to manage their pain, in order to better understand the effects of alcohol, as compared to opioid analgesics, on physical pain in daily life. Specific Aims This project will combine experimental and ambulatory assessment methods to investigate three possible and interrelated reasons for using alcohol to manage pain: (1) the similarity of alcohol's analgesic effects to those of prescription opioids, (2) whethr individuals who drink to reduce pain also drink to reduce other forms of stress, specifically emotional distress, and, (3) the association of chronic pain and tension reduction expectancies for alcohol use related to pain and emotional distress. The project will also determine to what degree a baseline pain response obtained under controlled conditions improves prediction of daily life events, such as experience of pain and emotional distress. Method Chronic back pain outpatients who regularly use alcohol, are prescribed and take opioid analgesics, both, or neither, will complete a laboratory pain-induction task to obtain a baseline pain response to a standardized stimulus. Participants will then provide information on alcohol and opioid use, physical pain, [alcohol and opioid use expectancies], and emotional distress in daily life using smartphones over the course of two weeks. Significance This translational research project will apply knowledge gained from basic research on alcohol use to the use of alcohol among chronic pain individuals in daily life. Evidence suggests that these individuals are at increased risk for the development of alcohol use problems. The findings from the current project may aid in the development of interventions that target this population.

 描述（由申请人提供）：该项目的目标是测试一个理论框架，解释为什么慢性疼痛患者会通过饮酒来控制疼痛，以便更好地了解酒精与阿片类镇痛药相比对日常生活中身体疼痛的影响。具体目标本项目将结合联合收割机实验和门诊评估方法，调查使用酒精来管理疼痛的三个可能的和相互关联的原因：（1）酒精的镇痛作用与处方阿片类药物的相似性，（2）饮酒以减轻疼痛的个体是否也饮酒以减轻其他形式的压力，特别是情绪困扰，以及，（3）慢性疼痛和紧张减少预期与疼痛和情绪困扰有关的酒精使用的关联。该项目还将确定在受控条件下获得的基线疼痛反应在多大程度上改善了对日常生活事件的预测，例如疼痛和情绪困扰的体验。方法慢性背痛门诊患者经常使用酒精，处方和阿片类镇痛药，两者或两者都不，将完成实验室疼痛诱导任务，以获得对标准化刺激的基线疼痛反应。然后，参与者将在两周内使用智能手机提供有关酒精和阿片类药物使用，身体疼痛，[酒精和阿片类药物使用预期]以及日常生活中情绪困扰的信息。意义本转化研究项目将从酒精使用的基础研究中获得的知识应用于慢性疼痛患者日常生活中的酒精使用。有证据表明，这些人患酒精使用问题的风险增加。目前项目的调查结果可能有助于制定针对这一人群的干预措施。