fMRI and Integrated Neurocardiac Control of Alcohol Cue Reactivity

酒精提示反应的功能磁共振成像和综合神经心脏控制

• 批准号: 8794390
• 负责人: MARSHA E. BATES
• 金额: $ 21.61万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8794390
• 关键词: Activation Analysis; Address; Affect; Alcohol consumption; Alcohol dependence; Alcohols; Area; Arousal; Attention; Back; Behavior Control; Behavior Therapy; Behavioral; Biological Neural Networks; Blood Pressure; Brain; Brain Stem; Brain imaging; Brain region; Breathing; Cardiovascular system; Chronic; Cognitive; Conscious; Cues; Data; Dependence; Disease; Electrocardiogram; Emotional; Environment; Feedback; Functional Magnetic Resonance Imaging; Goals; Graph; Health; Heart; Heart Rate; Human; Insula of Reil; Intervention; Knowledge; Learning; Link; Magnetic Resonance Imaging; Measures; Medial; Mediating; Organ; Participant; Pathway interactions; Persons; Phenotype; Physiological; Prefrontal Cortex; Process; Public Health; Randomized; Regulation; Relapse; Relative (related person); Research; Respiration; Sampling; Signal Transduction; Smell Perception; Stream; Structure; System; Testing; Time; Visceral; Vision; Work; afferent nerve; alcohol cue; alcohol exposure; alcohol relapse; alcohol response; alcohol seeking behavior; alcohol use disorder; base; blood oxygenation level dependent response; craving; cue reactivity; drinking; drinking behavior; emerging adult; experience; feeding; flexibility; heart rate variability; neurotransmission; novel; novel strategies; relating to nervous system; response; visual control; young adult

DESCRIPTION (provided by applicant): This R21 application is in response to PA-10-256: Behavioral Regulation Mechanisms of Alcohol Dependence and Related Phenotypes. In persons with alcohol use disorders, conscious attempts to regulate drinking behavior are often undermined by automatic processes that capture attention and instigate arousal in the context of alcohol cues. The persistence of heightened cue reactivity, even following treatment, contributes significantly to the public health burden of the chronic, relapsing disorder of alcohol dependence. Cue reactivity processes involve dynamic feedback loops between the brain and other bodily organs such as the heart. Yet, very little is known about how the brain and heart work together to give rise to heightened alcohol cue reactivity. We propose to address this gap by examining the neurocardiac feedback loop during exposure to alcohol picture cues (Aim 1). Further, there remains a need to develop interventions that effectively diminish reactivity in persons for whom automatic processes, such as those supported by the neurocardiac feedback loop, maintain alcohol cue salience. Thus, we further test whether a brief behavioral manipulation can significantly diminish neural and cardiovascular reactivity to alcohol cues (Aim 2). We will use functional magnetic resonance imaging (fMRI) to capture reactivity of the brain's central autonomic network (CAN) while simultaneously assessing cardiovascular changes during presentation of alcohol-related and neutral picture cues in a group of 24 non-treatment seeking emerging adults with alcohol dependence (DEP) compared to a matched sample of moderate drinking controls (MOD). Activation in selected CAN structures (medial prefrontal cortex, insula, brain stem) and neurocardiac signal variability (heart rate variability and blood pressure variability) in response to alcohol cues will be simultaneously assessed. Specific Aim 1 will examine differences in alcohol cue reactivity between DEP and MOD young adults in terms of brain activation, effective connectivity, and physiological measures of neurocardiac signaling. Specific Aim 2 will explore whether a behavioral manipulation of breathing at 0.1 Hz reduces neural and/or cardiovascular reactivity to alcohol cues. If successful, this application will yield support for a new approach wherein neurocardiac signaling can be linked in a time-varying manner to neural systems that modulate cue reactivity. Its potential public health significance is in exploring a behavioral regulation intervention that would be amenable to large scale dissemination and could be used within the treatment context or ad lib during moments of heightened vulnerability to relapse.

描述（由申请人提供）：本R21申请是对PA-10-256：酒精依赖和相关表型的行为调节机制的回应。在酒精使用障碍患者中，有意识地调节饮酒行为的努力常常被自动过程所破坏，这些过程会在酒精提示的背景下吸引注意力并激发唤醒。即使在治疗后，线索反应性持续升高，对慢性复发性酒精障碍的公共卫生负担有重大影响