(2/2) Howard University/Johns Hopkins Partnership in HPV-Related Cancer Research

 描述（由申请人提供）：本提案旨在通过与约翰霍普金斯医疗机构西德尼·金梅尔综合癌症中心的合作项目和有效的长期合作关系，改善霍华德大学的转化和基于社区的HPV相关癌症研究、教育和培训。人乳头瘤病毒（HPV）占全球癌症病例的5.2%。几种HPV菌株会导致各种毁灭性的生殖和口咽癌。在美国，每年诊断出约26，700例HPV相关癌症病例。非裔美国妇女患有HPV相关的宫颈癌，阴道癌和肛门癌的发病率明显高于白人。此外，在大约20-30%的头颈癌和大约56%的口咽癌和口腔癌中发现了HPV-16。霍华德大学医疗机构有一个历史上的黑人学生团体，其医疗和牙科设施参与直接服务于少数民族人口。然而，霍华德大学在癌症研究和健康差距方面面临着重大挑战。约翰霍普金斯致力于提供指导和教育资源，在癌症研究，以提高霍华德的能力。霍华德是一个领先的少数民族服务机构，而约翰霍普金斯是一个完善的国家癌症研究所指定的癌症中心。一项将关注少数民族的霍华德医生和牙医以及研究HPV相关癌症的约翰霍普金斯研究人员聚集在一起的教育工作将有助于解决社会经济差距和癌症健康，健康教育和健康相关专业的障碍。通过一系列合作试点项目，包括小鼠模型中的HPV疫苗开发，华盛顿社区队列的流行病学研究，以及两所大学之间广泛的指导网络，这种合作将显着提高职业发展，教育和竞争力，为霍华德学生和教育工作者寻求资助机会。具体目标是：1）支持霍华德大学医疗机构和约翰霍普金斯大学西德尼·金梅尔癌症中心之间的合作癌症研究项目; 2）提供合作培训和指导计划，以促进霍华德医学和牙科学生和教师在癌症研究，3）建立教育计划，促进癌症研究的知识，因为它适用于病因学，预防，诊断，在少数群体服务机构中治疗HPV相关癌症。

 DESCRIPTION (provided by applicant): This proposal aims to improve the translational and community-based HPV-associated cancer research, education, and training at Howard University through collaborative projects and an effective long-term partnership with Johns Hopkins Medical Institutions Sidney Kimmel Comprehensive Cancer Center. Human papillomavirus (HPV) accounts for 5.2% of cancer cases worldwide. Several strains of HPV cause a variety of devastating reproductive and oropharyngeal cancers. In the United States, about 26,700 cases of HPV-associated cancers are diagnosed annually. African American women suffer from a significantly higher incidence rate of HPV-associated cervical, vaginal, and anal cancers compared to their Caucasian counterparts. Additionally, HPV-16 has been identified in approximately 20-30% of head and neck cancers and roughly 56% of oropharynx and oral cavity cancers. Howard University Medical Institutions have a historically Black student body, and its medical and dental facilities participate in direct service to minority populations. However, Howard University faces significant challenges in cancer research and health disparities efforts. Johns Hopkins is committed to providing mentorship and educational resources in cancer research to improve Howard's capacities. Howard is a leading minority-serving institution, while Johns Hopkins is a well-established NCI-designated Cancer Center. An educational effort that brings together Howard doctors and dentists who focus on minorities and Johns Hopkins researchers who study HPV-related cancers will help to address socioeconomic disparities and barriers to cancer health, health education, and health-related professions. Through a set of collaborative pilot projects that include HPV vaccine development in mice models, epidemiology research in a Washington D.C. community cohort, and an extensive mentoring network between the two universities, this collaboration will significantly enhance career development, education, and competitiveness in seeking funding opportunities for Howard students and educators. Specific aims will be: 1) to support collaborative cancer research projects between the Howard University Medical Institutions and the Sidney Kimmel Cancer Center at Johns Hopkins; 2) to provide collaborative training and mentoring programs for promoting Howard medical and dental students and faculty in cancer research, 3) to establish education programs that advance the knowledge of cancer research as it applies to etiology, prevention, diagnosis, and treatment of HPV-associated cancer in the context of minority-serving institutions.