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(2/2) Howard University/Johns Hopkins Partnership in HPV-Related Cancer Research

(2/2) 霍华德大学/约翰霍普金斯大学在 HPV 相关癌症研究方面的合作

基本信息

批准号：
8850082
负责人：
TZYY-CHOOU WU
金额：
$ 14.69万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-20 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8850082
关键词：
Accounting Address African American Applications Grants Area Attitude Awareness Baltimore Cancer Center Cancer Research Project Caucasians Caucasoid Race Collaborations Commit Communities Comprehensive Cancer Center Data Dental Dental Facilities Dental Faculty Dental Students Dentistry Dentists Development Diagnosis District of Columbia Education Ensure Epidemiologic Studies Etiology Face Faculty Funding Funding Opportunities Goals Grant Head and Neck Cancer Health Health education Hispanics Historically Black Colleges and Universities Home environment Human Papilloma Virus Vaccine Human Papillomavirus Human papillomavirus 16 Incidence Institution Knowledge Lead Learning Malignant Neoplasms Malignant Vaginal Neoplasm Malignant neoplasm of anus Malignant neoplasm of cervix uteri Maryland Medical Medical Research Medical Students Medicine Mentors Mentorship Minority Minority-Serving Institution Motivation NCI-Designated Cancer Center National Cancer Institute Oral cavity Oropharyngeal Participant Patients Pilot Projects Population Preparation Prevention Process Publications Research Research Personnel Research Project Grants Research Training Resources Scientist Services Students System Training Training and Education Translational Research Underrepresented Minority Underserved Population United States United States National Institutes of Health Universities Washington Woman anticancer research base cancer diagnosis cancer education cancer health disparity career career development cohort college health disparity improved malignant mouth neoplasm malignant oropharynx neoplasm metropolitan mouse model multidisciplinary programs public health relevance reproductive skills socioeconomics undergraduate student university student vaccine development

项目摘要

DESCRIPTION (provided by applicant): This proposal aims to improve the translational and community-based HPV-associated cancer research, education, and training at Howard University through collaborative projects and an effective long-term partnership with Johns Hopkins Medical Institutions Sidney Kimmel Comprehensive Cancer Center. Human papillomavirus (HPV) accounts for 5.2% of cancer cases worldwide. Several strains of HPV cause a variety of devastating reproductive and oropharyngeal cancers. In the United States, about 26,700 cases of HPV-associated cancers are diagnosed annually. African American women suffer from a significantly higher incidence rate of HPV-associated cervical, vaginal, and anal cancers compared to their Caucasian counterparts. Additionally, HPV-16 has been identified in approximately 20-30% of head and neck cancers and roughly 56% of oropharynx and oral cavity cancers. Howard University Medical Institutions have a historically Black student body, and its medical and dental facilities participate in direct service to minority populations. However, Howard University faces significant challenges in cancer research and health disparities efforts. Johns Hopkins is committed to providing mentorship and educational resources in cancer research to improve Howard's capacities. Howard is a leading minority-serving institution, while Johns Hopkins is a well-established NCI-designated Cancer Center. An educational effort that brings together Howard doctors and dentists who focus on minorities and Johns Hopkins researchers who study HPV-related cancers will help to address socioeconomic disparities and barriers to cancer health, health education, and health-related professions. Through a set of collaborative pilot projects that include HPV vaccine development in mice models, epidemiology research in a Washington D.C. community cohort, and an extensive mentoring network between the two universities, this collaboration will significantly enhance career development, education, and competitiveness in seeking funding opportunities for Howard students and educators. Specific aims will be: 1) to support collaborative cancer research projects between the Howard University Medical Institutions and the Sidney Kimmel Cancer Center at Johns Hopkins; 2) to provide collaborative training and mentoring programs for promoting Howard medical and dental students and faculty in cancer research, 3) to establish education programs that advance the knowledge of cancer research as it applies to etiology, prevention, diagnosis, and treatment of HPV-associated cancer in the context of minority-serving institutions.

描述（由申请人提供）：该提案旨在通过合作项目以及与约翰霍普金斯医疗机构西德尼金梅尔综合癌症中心的有效长期合作伙伴关系，改善霍华德大学的转化和基于社区的 HPV 相关癌症研究、教育和培训。人乳头瘤病毒 (HPV) 占全球癌症病例的 5.2%。 HPV 的几种毒株会导致多种毁灭性的生殖癌和口咽癌。在美国，每年诊断出约 26,700 例 HPV 相关癌症病例。与白人女性相比，非裔美国女性患 HPV 相关宫颈癌、阴道癌和肛门癌的发病率明显更高。此外，大约 20-30% 的头颈癌和大约 56% 的口咽癌和口腔癌中都发现了 HPV-16。霍华德大学医疗机构历史上一直有黑人学生团体，其医疗和牙科设施直接为少数族裔提供服务。然而，霍华德大学在癌症研究和健康差异方面面临着重大挑战。约翰霍普金斯大学致力于提供癌症研究方面的指导和教育资源，以提高霍华德的能力。霍华德大学是一家领先的少数族裔服务机构，而约翰霍普金斯大学是一家完善的 NCI 指定癌症中心。霍华德大学专注于少数族裔的医生和牙医以及约翰·霍普金斯大学研究 HPV 相关癌症的研究人员共同开展的教育工作将有助于解决社会经济差异以及癌症健康、健康教育和健康相关职业的障碍。通过一系列合作试点项目，包括小鼠模型中的 HPV 疫苗开发、华盛顿特区社区队列的流行病学研究以及两所大学之间广泛的指导网络，此次合作将显着增强霍华德学生和教育工作者在寻求资助机会方面的职业发展、教育和竞争力。具体目标是： 1）支持霍华德大学医疗机构和约翰霍普金斯大学悉尼金梅尔癌症中心之间的合作癌症研究项目； 2) 提供协作培训和指导计划，以促进霍华德医学和牙科学生和教师进行癌症研究，3) 建立教育计划，以提高癌症研究知识，因为它适用于少数民族服务机构中 HPV 相关癌症的病因学、预防、诊断和治疗。