(2/2) Howard University/Johns Hopkins Partnership in HPV-Related Cancer Research

 描述(由申请人提供)：这项建议旨在通过与约翰霍普金斯大学医疗机构Sidney Kimmel综合癌症中心的合作项目和有效的长期合作伙伴关系，改善霍华德大学的翻译和基于社区的HPV相关癌症研究、教育和培训。人类乳头瘤病毒(HPV)占全球癌症病例的5.2%。HPV的几种毒株会导致各种毁灭性的生殖癌和口咽癌。在美国，每年约有2.67万例HPV相关癌症被诊断出来。与高加索女性相比，非裔美国女性患HPV相关宫颈癌、阴道癌和肛门癌的发病率要高得多。此外，在大约20%-30%的头颈癌和大约56%的口咽癌和口腔癌中发现了HPV-16。霍华德大学医疗机构拥有历史上的黑人学生群体，其医疗和牙科设施直接为少数族裔人口提供服务。然而，霍华德大学在癌症研究和健康差距方面面临着巨大的挑战。约翰霍普金斯大学致力于在癌症研究方面提供指导和教育资源，以提高霍华德的能力。霍华德是一家领先的少数族裔服务机构，而约翰霍普金斯大学是一家久负盛名的NCI指定癌症中心。一项教育努力将专注于少数族裔的霍华德医生和牙医以及研究HPV相关癌症的约翰·霍普金斯大学的研究人员聚集在一起，这将有助于解决社会经济差距和癌症健康、健康教育和健康相关职业的障碍。通过一系列合作试点项目，包括在老鼠模型中开发HPV疫苗，在华盛顿特区社区队列中进行流行病学研究，以及两所大学之间广泛的指导网络，这种合作将显著提高职业发展、教育和为霍华德学生和教育工作者寻求资助机会的竞争力。具体目标将是：1)支持霍华德大学医疗机构和约翰霍普金斯大学西德尼·基梅尔癌症中心之间的合作癌症研究项目；2)提供合作培训和指导计划，促进霍华德医学和牙科学生和教职员工在癌症研究方面的知识；3)建立教育计划，在少数族裔服务机构的背景下，提高癌症研究的知识，使其适用于HPV相关癌症的病因、预防、诊断和治疗。

 DESCRIPTION (provided by applicant): This proposal aims to improve the translational and community-based HPV-associated cancer research, education, and training at Howard University through collaborative projects and an effective long-term partnership with Johns Hopkins Medical Institutions Sidney Kimmel Comprehensive Cancer Center. Human papillomavirus (HPV) accounts for 5.2% of cancer cases worldwide. Several strains of HPV cause a variety of devastating reproductive and oropharyngeal cancers. In the United States, about 26,700 cases of HPV-associated cancers are diagnosed annually. African American women suffer from a significantly higher incidence rate of HPV-associated cervical, vaginal, and anal cancers compared to their Caucasian counterparts. Additionally, HPV-16 has been identified in approximately 20-30% of head and neck cancers and roughly 56% of oropharynx and oral cavity cancers. Howard University Medical Institutions have a historically Black student body, and its medical and dental facilities participate in direct service to minority populations. However, Howard University faces significant challenges in cancer research and health disparities efforts. Johns Hopkins is committed to providing mentorship and educational resources in cancer research to improve Howard's capacities. Howard is a leading minority-serving institution, while Johns Hopkins is a well-established NCI-designated Cancer Center. An educational effort that brings together Howard doctors and dentists who focus on minorities and Johns Hopkins researchers who study HPV-related cancers will help to address socioeconomic disparities and barriers to cancer health, health education, and health-related professions. Through a set of collaborative pilot projects that include HPV vaccine development in mice models, epidemiology research in a Washington D.C. community cohort, and an extensive mentoring network between the two universities, this collaboration will significantly enhance career development, education, and competitiveness in seeking funding opportunities for Howard students and educators. Specific aims will be: 1) to support collaborative cancer research projects between the Howard University Medical Institutions and the Sidney Kimmel Cancer Center at Johns Hopkins; 2) to provide collaborative training and mentoring programs for promoting Howard medical and dental students and faculty in cancer research, 3) to establish education programs that advance the knowledge of cancer research as it applies to etiology, prevention, diagnosis, and treatment of HPV-associated cancer in the context of minority-serving institutions.