Language development and linguistic processing after left hemisphere perinatal stroke

左半球围产期卒中后的语言发展和语言处理

• 批准号: 8878696
• 负责人: ELISSA L NEWPORT
• 金额: $ 17.46万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8878696
• 关键词: Academic Medical Centers; Adult; Aphasia; Area; Automobile Driving; Award; Behavior assessment; Behavioral; Birth; Brain; Brain Injuries; Brain imaging; Child; Child Language; Childhood stroke; Chronic; Clinical; Cognition; Complex; Crowding; Data; Development; Educational workshop; Epilepsy; Exhibits; Faculty; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Goals; Health; Homologous Gene; Hospitals; Human; Image; Imaging Techniques; Individual; Injury; Ischemic Stroke; K-18 conjugate; Language; Language Development; Lead; Learning; Left; Left cerebral hemisphere; Life; Light; Linguistics; Literature; Mentors; Methods; Nature; Neuropsychological Tests; Outcome; Patients; Pattern; Performance; Perinatal; Plastics; Population; Positioning Attribute; Procedures; Process; Reading; Recovery; Recruitment Activity; Rehabilitation therapy; Research; Research Personnel; Research Training; Seizures; Stroke; Structure; Techniques; Time; Training; Universities; Variant; Work; behavioral study; career; cognitive function; developmental plasticity; driving force; experience; grasp; hemisphere damage; improved; insight; interest; language processing; meetings; middle cerebral artery; motor impairment; neural patterning; neuromechanism; neuropsychological; novel strategies; patient population; perinatal stroke; post stroke; public health relevance; relating to nervous system; research study; skills; stroke recovery; syntax

 DESCRIPTION (provided by applicant): For 35 years I have worked on language acquisition, conducting behavioral studies of children learning their first languages and the mechanisms of learning that make children so skilled in language acquisition. I've recently become interested in the related question of developmental plasticity in recovery from brain injury. I spent 2011-12 as a visitor to Georgetown University Medical Center (GUMC) and the National Rehabilitation Hospital (NRH), where I observed adult and child stroke patients and fMRI studies of language reorganization in epilepsy. I found this work completely gripping and am now refocusing my research on stroke recovery in children. In July 2012 I accepted a faculty position at Georgetown University as Director of a Center for Brain Plasticity and Recovery and have been starting to do research on pediatric stroke recovery. I am applying for a K18 award to provide myself with time over the next 2 years to enhance my research skills in studying the organization of language after childhood stroke, through a comprehensive and well- structured training and research plan under the direction of the outstanding mentors and consultants available to me at GUMC, NRH, and CNMC. I have already done extensive clinical observation. My training plan includes coursework, individual meetings, directed readings, and research training on using neuropsychological, fMRI, and DTI techniques to understand neural mechanisms of reorganization of language in children after perinatal stroke. My mentors will be Dr. Alexander Dromerick (adult stroke recovery, patient recruiting and research) and Dr. William Gaillard (fMRI research on child language reorganization after brain injury), with a team that will train me on adult aphasia and recovery (Dr. Peter Turkeltaub), pediatric stroke (Dr. Jessica Carpenter), functional imaging (Dr. John VanMeter), neuropsychological assessment (Dr. Madison Berl), and advanced techniques in analysis of patient and stroke imaging (Dr. Peter Turkeltaub) and in connectivity analyses (Dr. Chandan Vaidya). I will attend a course on fMRI and an advanced fMRI workshop and attend a semester-long course at GUMC providing advanced training in responsible conduct in research. I will also conduct a research study on language in children who have had a left hemisphere perinatal stroke. This project will focus on older children, many years after stroke, using fMRI, DTI, and behavioral techniques to examine the patterns and principles of how language is organized in the brain after stroke. The ultimate aim of this work is to improve stroke recovery in children and adults by understanding successful language organization in children. While this long-term goal is beyond the scope of the present proposal, the proposed training will be crucial in allowing me to proceed on to independent research in this new field.

 描述（由申请人提供）：35年来，我一直致力于语言习得，进行儿童学习第一语言的行为研究，以及使儿童在语言习得方面如此熟练的学习机制。我最近对脑损伤恢复过程中的发育可塑性的相关问题产生了兴趣。我花了2011-12作为访问者乔治敦大学医学中心（GUMC）和国家康复医院（NRH），在那里我观察了成人和儿童中风患者和癫痫语言重组的fMRI研究。我发现这项工作完全扣人心弦，现在我重新关注我的研究中风恢复儿童。2012年7月，我接受了乔治敦大学的一个教职，担任大脑可塑性和恢复中心的主任，并开始研究儿童中风的恢复。我正在申请K18奖，以便在未来2年内为自己提供时间，通过在GUMC，NRH和CNMC的优秀导师和顾问的指导下，通过全面和结构良好的培训和研究计划，提高我在研究儿童中风后语言组织方面的研究技能。我已经做了大量的临床观察。我的培训计划包括课程作业，个人会议，定向阅读，以及使用神经心理学，功能磁共振成像和DTI技术了解围产期中风后儿童语言重组的神经机制的研究培训。我的导师将是亚历山大德罗梅里克博士（成人中风恢复，患者招募和研究）和威廉盖拉尔博士（脑损伤后儿童语言重组的功能磁共振成像研究）， 对我进行成人失语症和康复（Peter Turkeltaub博士）、儿童中风（Jessica Carpenter博士）、功能成像（John VanMeter博士）、神经心理评估（麦迪逊·贝尔博士）以及患者和中风成像分析（Peter Turkeltaub博士）和连接分析（Chandan Vaidya博士）的先进技术培训。我将参加一个关于功能性磁共振成像的课程和一个高级功能性磁共振成像研讨会，并参加一个为期一学期的课程，在GUMC提供高级培训，在研究中负责任的行为。我还将进行一项关于左半球围产期中风儿童语言的研究。该项目将重点关注中风后多年的大龄儿童，使用fMRI，DTI和行为技术来检查中风后语言在大脑中组织的模式和原则。这项工作的最终目的是通过了解儿童成功的语言组织来改善儿童和成人的中风恢复。虽然这一长期目标超出了目前建议的范围，但拟议的培训将是至关重要的，使我能够继续在这个新领域进行独立研究。