Training in Congenital and Acquired Heart Disease

 描述(由申请人提供)：俄亥俄州立大学(OSU)和全国儿童医院(NCH)T32机构联合博士后项目的竞争性更新的目标是在先天性和获得性心脏病方面提供跨学科、翻译和最先进的研究培训。这一计划提供了一个独特的机会，可以集中研究从胎儿到衰老的先天性和获得性心脏病的连续体，并比较这些不同人群之间的疾病机制和结果。其基本原理是，心脏病治疗和预防方面的进步最有可能源于一项转化性研究计划，该计划促进了医生科学家和基础科学家之间的合作。我们将继续努力提供一个学术环境，培养真正的“双向”研究，以便我们的内科科学家发现的重大临床问题可以在实验室解决，而在试验台上的关键发现可以迅速转化为更大的动物研究并返回床边。本次续签申请为期5年，每年招收6名实习生，为期2-3年。研究员将从对心血管研究有浓厚兴趣并致力于以疾病为导向的研究的MD、DVM、药学博士或博士学员中挑选。项目主任在转化性心血管研究和指导方面有着良好的记录，并将担任各自机构的主要主任。培训计划设计包括正式的学术课程、研讨会和期刊俱乐部，为学员提供心脏病概述和深入的心脏研究方向。学员将参加一个量身定做的“生存技能”课程，其中包括与专业发展有关的各种单元和工作坊。每个学员将在导师的实验室进行独立的研究项目。由34名外部资助的基础和临床科学导师和3名参与的教员所涵盖的研究领域由他们与国立卫生研究院心脏中心的个人关系所代表。 以及俄亥俄州立大学的戴维斯心肺研究所。培训计划中增加了一条新的临床研究人员途径，以增加MD研究员的临床研究机会。这条途径将由J·菲尔·索尔医学博士指导，他是国际公认的内科科学家和儿科主席。介绍了一项积极的、代表性不足的少数族裔招聘和留用计划，以增加受训人员的多样性。将使用跨机构系统进行实习生和导师评估。确定成功的总体标准包括内部和外部咨询委员会的计划审查，以及每个受训人员个人发展计划的成功执行。学员的具体衡量标准包括完成规定的课程作业、指导团队的年度评估，以及通过同行评议的手稿和摘要的数量、在全国会议上的陈述和拨款申请(NIH K、R21和/或基金拨款)来评估研究效率。

 DESCRIPTION (provided by applicant): The objective of the competitive renewal of this joint Ohio State University (OSU)-Nationwide Children's Hospital (NCH) institutional T32 postdoctoral program is to provide interdisciplinary, translational, and state- of-the-art research training in congenital and acquired heart disease. This plan provides a unique opportunity to focus on a continuum of congenital and acquired heart disease from fetal life to senescence and to compare disease mechanisms and outcomes between these diverse populations. The rationale is that advances in heart disease therapy and prevention are most likely to originate from a translational research program that fosters collaboration between physician-scientists and basic scientists. We will expand ongoing efforts to provide an academic environment to cultivate true `bidirectional' research, so that significant clinical problems identified by our physician scientits can be addressed in the laboratory, and key findings at the bench can be rapidly translated to larger animal studies and back to the bedside. This renewal application seeks 6 trainees per year for 5 years with a 2-3 year commitment. Fellows will be selected from MD, DVM, Pharm.D. or PhD trainees who have strong interests in cardiovascular research and are committed to careers in disease-oriented investigations. The Program Directors have a strong-track record in translational cardiovascular research and mentoring and will serve as the primary directors at their respective institutions. The training plan design consists of formal academic courses, seminars and journal clubs to provide trainees with an overview of heart disease and an in-depth cardiac research orientation. Trainees will participate in a tailor-made "survival skills" course comprised of various modules and workshops related to professional development. Each trainee will perform independent research projects in a mentor's laboratory. The research areas encompassed by the 34 extramurally-funded basic- and clinical- science mentors and 3 participating faculty are represented by their individual affiliations with The Heart Center at NCH and The Davis Heart and Lung Research Institute at Ohio State. A new clinical investigator pathway is added to the training program to enhance clinical research opportunities for MD fellows. The pathway will be directed by J. Phil Saul, MD, an internationally recognized physician-scientist and Chair of Pediatrics. An aggressive underrepresented minority recruitment and retention plan is described to increase trainee diversity. A cross-institutional system will be used to perform trainee and mentor evaluations. Overall metrics to determine success include programatic review by internal and external advisory committees and the successful execution of each trainee's individual development program. Trainee-specific metrics include completion of required coursework, annual evaluation by the mentoring team, and research productivity as assessed by the number of peer-reviewed manuscripts and abstracts, presentations at national meetings and grant submissions (NIH K, R21 and/or foundation grants).